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  • HCV core  (1)
  • high performance liquid chromatography  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Clinical study of IgA antibody against hepatitis C virus core antigen in patients with type C chronic liver disease (1995)
    Springer
    Digestive diseases and sciences 40 (1995), S. 457-464 
    Details
    ISSN: 1573-2568
    Keywords: IgA class antibody ; type C chronic liver disease ; HCV core ; histological activity ; IFN therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Immunoglobulin A class antibody to hepatitis C virus core antigen (IgA anti-HCc) was measured in the serum of 128 patients with type C chronic liver disease. Fifty-eight patients (45.3%) were seropositive. IgA anti-HCc was detected in only one of 20 patients with chronic persistent hepatitis; however, 52.3% (46/88) of patients with chronic active hepatitis and 55% (11/20) of patients with liver cirrhosis were seropositive. Histological examination revealed that 22 (71.0%) of 31 patients with severe disease activity were seropositive compared to 35 (44.9%) of 78 patients with moderate (P〈0.05) and one (5.3%) of 19 patients with mild (P〈0.01) histological changes. IgA anti-HCc was measured sequentially in 65 patients who underwent interferon therapy. There was a significant difference between responders and other patients in the mean ratio of IgA anti-HCc titers one month after therapy. Three months after therapy, IgA anti-HCc was detectable in only two of 15 responders who were IgA anti-HCc seropositive at the start of therapy. In contrast, IgA anti-HCc reappeared three months after therapy despite a temporary decrease to undetectable levels in all nonresponders. We conclude that IgA anti-HCc is a useful marker to identify the presence of active type C liver disease and that the disappearance of IgA anti-HCc three months after interferon therapy predicts a good response in treated patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02065435
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    IgM and IgA antibodies generated against hepatitis C virus core antigen in patients with acute and chronic HCV infection (1994)
    Springer
    Digestive diseases and sciences 39 (1994), S. 2022-2031 
    Details
    ISSN: 1573-2568
    Keywords: hepatitis C virus ; IgA ; IgM ; IgG ; HCV RNA ; high performance liquid chromatography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Antibody subclasses directed against the core protein (HCc) of hepatitis C virus (HCV) were measured in 27 patients with acute non-A, non-B (NANB) hepatitis, and 99 patients with chronic HCV-associated liver disease. IgM, IgA, and IgG anti-HCc responses were observed in 11 (40.7%), 7 (25.9%), and 18 (67%) patients with acute NANB hepatitis, respectively. Twenty-four (24.2%) and 40 (40.4%) patients with chronic HCV infection also had detectable IgM and IgA, respectively. IgM anti-HCc inconsistently detected acute infection, and HCV ribonucleic acid (RNA) could be detected preceding the rise in anti-HCc antibodies in five consecutive patients with acute hepatitis. IgM anti-HCc also could not distinguish acute from chronic infection and did not correlate with histologic progression. However, the form of IgA present (polymeric vs monomeric) did discriminate acute from chronic infection and the IgA anti-HCc titer correlated with histologic evidence of liver disease in patients with chronic HCV infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02088141
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    Paper (German National Licenses)
    Fulltext
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