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  • 1
    Electronic Resource
    Electronic Resource
    Glucose metabolism in relation to perfusion in patients with ischaemic heart disease (1994)
    Springer
    European journal of nuclear medicine 21 (1994), S. 292-296 
    Details
    ISSN: 1619-7089
    Keywords: Glucose metabolism ; Myocardial perfusion ; Positron emission tomography ; Myocardial viability ; Ischaemic heart disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to correlate myocardial perfusion and residual metabolism in patients with coronary artery disease, the regional metabolic rate of glucose (rMRGlu) was compared with regional perfusion under glucose loading state (GL) and fasting state (FA). Fluorine-18 deoxyglucose dynamic scan was obtained in ten patients after oral GL and in 16 patients under FA. rMRGlu in seven segments was calculated using Patlak graphic analysis for comparison with normalized percent uptake of nitrogen-13 ammonia at rest in each segment. When perfusion was less than 45%, no segment showed an increase in rMRGlu (≥0.3 pmol/min/g) under either FA (0/6 segments) or GL (0/8 segments), indicating a certain threshold of perfusion for maintenance of glucose metabolism. When perfusion exceeded 45%, rMRGlu was higher in GL (0.37±0.18 pmol/min/g) than FA (0.15±0.12 pmoVmin/g,P 〈 0.001) but there was very wide scatter of rMRGlu values under both states. Thus, both myocardium with preserved and myocardium with reduced glucose metabolism may exist when the perfusion exceeds 45%. In conclusion, a minimum threshold of perfusion for the maintenance of glucose metabolism may exist under both FA and GL. Below the threshold, irreversible damage may occur in the myocardium. Above the threshold, quantitative analysis of glucose metabolism should play an important role in differentiating reversibly injured myocardium from necrotic myocardium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00947963
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Oxidative metabolism in the myocardium in normal subjects during dobutamine infusion (1993)
    Springer
    European journal of nuclear medicine 20 (1993), S. 231-237 
    Details
    ISSN: 1619-7089
    Keywords: Positron emission tomography ; Carbon-11 acetate ; Myocardial metabolism ; Dobutamine ; Oxygen consumption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To assess the biventricular response of the clearance rate of carbon-11 acetate as an index of myocardial oxidative metabolism to increase in work-load, dynamic positron emission tomography was performed at rest and during dobutamine infusion in 14 normal subjects. The clearance rate constant (Kmono) of the left ventricular (LV) myocardium increased during dobutamine infusion (0.112±0.020 min−1 vs 0.065±0.015 min−1 at rest) (P〈0.001) in proportion to the increase in the pressure-rate product. Kmono in the right ventricular (RV) myocardium also increased (0.080±0.018 min−1 vs 0.034±0.013 min−1 at rest) (P〈0.001), with an excellent correlation with the LV Kmono (r=0.920). The fact that the increase in RV Kmono during dobutamine infusion was greater (158%±81%) than that in LV Kmono (79%±39%) (P 〈 0.005) indicates a greater increase in oxidative metabolism in the RV in response to inotropic stimulation in normal subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00170004
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Glucose metabolism in relation to perfusion in patients with ischaemic heart disease (1994)
    Springer
    European journal of nuclear medicine 21 (1994), S. 292-296 
    Details
    ISSN: 1619-7089
    Keywords: Glucose metabolism ; Myocardial perfusion ; Positron emission tomography ; Myocardial viability ; Ischaemic heart disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to correlate myocardial perfusion and residual metabolism in patients with coronary artery disease, the regional metabolic rate of glucose (rMRGlu) was compared with regional perfusion under glucose loading state (GL) and fasting state (FA). Fluorine-18 deoxyglucose dynamic scan was obtained in ten patients after oral GL and in 16 patients under FA. rMRGlu in seven segments was calculated using Patlak graphic analysis for comparison with normalized percent uptake of nitrogen-13 ammonia at rest in each segment. When perfusion was less than 45%, no segment showed an increase in rMRGlu (≥0.3 pmol/min/g) under either FA (0/6 segments) or GL (0/8 segments), indicating a certain threshold of perfusion for maintenance of glucose metabolism. When perfusion exceeded 45%, rMRGlu was higher in GL (0.37±0.18 pmol/min/g) than FA (0.15±0.12 pmoVmin/g, P 〈 0.001) but there was very wide scatter of rMRGlu values under both states. Thus, both myocardium with preserved and myocardium with reduced glucose metabolism may exist when the perfusion exceeds 45%. In conclusion, a minimum threshold of perfusion for the maintenance of glucose metabolism may exist under both FA and GL. Below the threshold, irreversible damage may occur in the myocardium. Above the threshold, quantitative analysis of glucose metabolism should play an important role in differentiating reversibly injured myocardium from necrotic myocardium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00176567
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Myocardial ischemia enhances the expression of acidic fibroblast growth factor in human pericardial fluid (2000)
    Springer
    Heart and vessels 15 (2000), S. 112-116 
    Details
    ISSN: 1615-2573
    Keywords: Key words Collateral circulation ; Growth factor ; Ischemia ; Myocyte ; Reperfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acidic fibroblast growth factor (FGF) is a potent mitogen that can induce angiogenesis in vivo. We have recently reported a marked increase of basic FGF in the pericardial fluid of patients with severe coronary stenosis and an increase in vascular endothelial growth factor (VEGF) in the pericardial fluid of patients with severe myocardial ischemia. The purpose of this study was to evaluate whether acidic FGF levels in the pericardial fluid are associated with severe myocardial ischemia. Immediately after incision of the pericardium in 48 patients during open-heart surgery, 3–5 ml of pericardial fluid was obtained. Concentrations of basic FGF and VEGF in the pericardial fluid were measured using an enzyme-linked immunosorbent assay (ELISA). The ELISA system for human acidic FGF was newly developed using a rabbit antibovine acidic FGF antibody. The patients were divided into three groups (group A: 13 patients undergoing emergency coronary artery bypass grafting (CABG) for unstable angina; group B: 17 patients undergoing elective CABG for stable angina; group C: 18 patients undergoing nonischemic open-heart surgery). The VEGF level in the pericardial fluid in group A was 68 ± 59 pg/ml, which was significantly higher than 33 ± 9 pg/ml in group B and 31 ± 20 pg/ml in group C (P 〈 0.05). The concentrations of basic FGF in the pericardial fluid in groups A and B were 722 ± 601 and 773 ± 763 pg/ml, respectively, significantly higher than 263 ± 349 pg/ml in group C. The pericardial acidic FGF level in group A was 4 291 ± 2 336 pg/ml, which was also significantly higher than 2 386 ± 1 048 pg/ml in group B and 2 589 ± 990 pg/ml in group C (P 〈 0.05). The acidic FGF level correlated well with the level of VEGF (r = 0.61, P 〈 0.0001). It is concluded that the level of acidic FGF in pericardial fluid is associated with severe myocardial ischemia. This result indicates that the release of acidic FGF from the myocardial tissue into pericardial fluid is closely related to severe myocardial ischemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007264
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    Paper (German National Licenses)
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