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  • Gene regulation, Lipid and lipoprotein metabolism  (1)
  • Laterite  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Environmental geology 23 (1994), S. 36-40 
    ISSN: 1432-0495
    Keywords: Sinkholes ; Laterite ; Brazil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Brasilia, the capital city of Brazil, is located in the central region of the country. Climate in the area is semitropical with an annual rainfall of 1500 mm. The geological environment in the area consists of low-grade metamorphic rocks. Slates of varying colors, metasiltstone, and quartzite beds are present. Over the Precambrian rocks is a lateritic layer varying in thickness from centimeters up to 30 m. Latosol dominates the existing plateaus, while laterite crusts and immature soils are dominant in the transition zones between plateaus and river valleys. Erosional problems related to the lateritic terrains were known prior to the settlement of the city in 1961. During 1986, erosion became a serious threat when several pseudosinkholes occurred in the urban area. Occurrence of pseudosinkholes resulted in condemnation of an area of 300,000 m2 and the demolition of several buildings. Preliminary studies indicated at the time that underground erosion and pseudosinkholes were generated by shortening of the percolation path of groundwater due to the progress, toward the residential area, of large gullies. This produced an increase in the hydraulic gradient, resulting in the removal of latosol particles. Occurrence of pseudosinkholes in other areas of the city has led the Institute of Geosciences to investigate the problem in more detail. Studies have been conducted looking for correlation between pseudosinkhole occurrence and geologic, geomorphic, geotechnical, and urban development features. Recent results show a much more complex process then previously thought. Field data suggests that termite activity and recharge of the water table by inadequate disposal of residential sewer systems are directly related to the problem.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2015-05-21
    Description: Objective— Liver X receptors (LXRs) modulate cholesterol and fatty acid homeostasis as well as inflammation. This study aims to decipher the role of LXRs in the regulation of polyunsaturated fatty acid (PUFA) synthesis in macrophages in the context of atherosclerosis. Approach and Results— Transcriptomic analysis in human monocytes and macrophages was used to identify putative LXR target genes among enzymes involved in PUFA biosynthesis. In parallel, the consequences of LXR activation or LXR invalidation on PUFA synthesis and distribution were determined. Finally, we investigated the impact of LXR activation on PUFA metabolism in vivo in apolipoprotein E–deficient mice. mRNA levels of acyl-CoA synthase long-chain family member 3, fatty acid desaturases 1 and 2, and fatty acid elongase 5 were significantly increased in human macrophages after LXR agonist treatment, involving both direct and sterol responsive element binding protein-1–dependent mechanisms. Subsequently, pharmacological LXR agonist increased long chain PUFA synthesis and enhanced arachidonic acid content in the phospholipids of human macrophages. Increased fatty acid desaturases 1 and 2 and acyl-CoA synthase long-chain family member 3 mRNA levels as well as increased arachidonic acid to linoleic acid and docosahexaenoic acid to eicosapentaenoic acid ratios were also found in atheroma plaque and peritoneal foam cells from LXR agonist–treated mice. By contrast, murine LXR-deficient macrophages displayed reduced expression of fatty acid elongase 5, acyl-CoA synthase long-chain family member 3 and fatty acid desaturases 1, as well as decreased cellular levels of docosahexaenoic acid and arachidonic acid. Conclusions— Our results indicate that LXR activation triggers PUFA synthesis in macrophages, which results in significant alterations in the macrophage lipid composition. Moreover, we demonstrate here that LXR agonist treatment modulates PUFA metabolism in atherosclerotic arteries.
    Keywords: Gene regulation, Lipid and lipoprotein metabolism
    Print ISSN: 1079-5642
    Electronic ISSN: 1524-4636
    Topics: Medicine
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