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  • 1
    Online Resource
    Online Resource
    The Physiology of Truth : Neuroscience and Human Knowledge. (2004)
    Cambridge :Harvard University Press,
    Details
    Keywords: Neurosciences. ; Brain-Physiology. ; Knowledge, Theory of. ; Mind-brain identity theory. ; Science-Methodology. ; Electronic books.
    Description / Table of Contents: Changeux confronts an ancient philosophical problem: can we know the world as it really is? Drawing on new findings on the psychophysiology of perception and judgment in primates, and on the cultural history of science, he makes a case for scientific progress and argues that it forms the basis for a coherent and universal theory of human rights.
    Type of Medium: Online Resource
    Pages: 1 online resource (333 pages)
    Edition: 1st ed.
    ISBN: 9780674029415
    Series Statement: Mind/Brain/Behavior Initiative Series
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=3300451
    DDC: 612.8
    Language: English
    Note: Intro -- Contents -- Introduction -- 1. Thinking Matter -- 2. The Acquisition of Knowledge -- 3. States of Consciousness -- 4. Knowledge and Social Life -- 5. From Genes to Brain -- 6. Neuronal Epigenesis and Cultural Evolution -- 7. Scientific Research and the Search for Truth -- 8. The Humanity of Science -- Conclusion -- Notes -- Credits -- Acknowledgments -- Index.
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  • 2
    Electronic Resource
    Electronic Resource
    Molecular evolution of the nicotinic acetylcholine receptor: An example of multigene family in excitable cells (1995)
    Springer
    Journal of molecular evolution 40 (1995), S. 155-172 
    Details
    ISSN: 1432-1432
    Keywords: Nicotinic receptor ; Ligand-gated channel ; Multigene family ; Gene phylogeny
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract An extensive phylogenetic analysis of the nicotinic-acetylcholine-receptor subunit gene family has been performed by cladistic and phenetic methods. The conserved parts of amino acid sequences have been analyzed by CLUSTAL V and PHYLIP software. The structure of the genes was also taken in consideration. The results show that a first gene duplication may have occurred before the appearance of Bilateria. Three subfamilies then appeared: I-the neuronal α-bungarotoxin binding-site subunits (α7, α8); III-the neuronal nicotinic subunits (α2–α6, β2–β4), which also contain the muscle acetylcholine-binding subunit (α1); and IV—the muscle non-α subunits (β1, γ δ, ε). The Insecta subunits (subfamily II) could be orthologous to family III and IV. Several tissular switches of expression from neuron to muscle and the converse can be inferred from the extant expression of subunits and the reconstructed trees. The diversification of the neuronal nicotinic subfamily begins in the stem lineage of chordates, the last duplications occurring shortly before the onset of the mammalian lineage. Such evolution parallels the increase in complexity of the cholinergic systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167110
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