ISSN:
1432-1440
Keywords:
Function and physico-chemical properties of proteoglycans
;
dermatological diseases
;
Stellung
;
Funktion
;
physiko.-biochem
;
Eigenschaften der Proteoglycane in der Dermatologie
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Description / Table of Contents:
Zusammenfassung Die Ergebnisse moderner Bindegewebsforschungen zwingen zu einer Überprüfung und Neuorientierung älterer pathogenetischer Vorstellungen. In einer Übersicht sollte versucht werden, den Stellenwert der Proteoglycane (PG) — ältere Bezeichnung Mucopolysaccharide (MPS) — im dermatologischen Bereich an Beispielen zu beleuchten. Hierbei kommt den PG im Rahmen des Sklerodermieproblems eine besondere Bedeutung zu (Matritzenfunktion).
Notes:
Summary Proteoglycans—high molecular polysaccharide-protein-complex compounds—are very important in vital intracellular and extracellular metabolic functions. Disturbances of their regulatory mechanisms are followed by an increase of their rate of biosynthesis. This obviously causes a partially irreversible damage in the connective tissue of the skin which is clinically and morphologically visible in a number of dermatological diseases. The importance of these macro-molecular structures and their metabolism is described in detail, especially as regards progressive scleroderma. The results of the most recent experiments lead cogent reason to abandon the former hypothesis that the mesenchymal cells possess a low metabolism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01467769
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