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  • Immunohistochemistry  (3)
  • Functional response  (2)
  • Liver  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of cardiodilatin in myoendocrine cells of the cardiac atria (1984)
    Springer
    Anatomy and embryology 170 (1984), S. 123-127 
    Details
    ISSN: 1432-0568
    Keywords: Heart Atrium ; Myoendocrine cells ; Cardiodilatin ; Peptide hormone ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Region-specific antibodies against synthetic N-terminal fragments of cardiodilatin (CDD) were raised in rabbits and used for the immunohistochemical detection of this new peptide hormone in the myoendocrine cells within the cardiac atria of several species. The peroxidase-antiperoxidase (PAP) and fluorescein isothiocyanate (FITC) immunohistochemical methods gave identical results of cardiodilatin-immunoreactivity (CDD-IR) within the tissue. In addition to the porcine right atrial appendage, myoendocrine cells with CDD-IR were also detected in the left atrium of porcine heart, as well as in other species such as dog and cat. The exact localization of the immunoreactivity in specific secretory granules was mostly related to the Golgi-area which is located on both nuclear poles of auricular myoendocrine cells. The results confirm that cardiodilatin is stored in secretory granules observed through electron microscopical means. This hormone is most likely synthesized and released in myoendocrine cells, exerting its important cardiovascular effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00318996
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Distribution of calcitonin gene-related peptide-like immunoreactivity in the guinea pig heart (1986)
    Springer
    Anatomy and embryology 175 (1986), S. 255-260 
    Details
    ISSN: 1432-0568
    Keywords: Immunohistochemistry ; Calcitonin gene-related peptide ; Heart innervation ; Guinea pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The distribution of calcitonin gene-related peptide like-immunoreactivity (CGRP-IR) within the heart and adjacent blood vessels of the guinea pig was investigated anmunohistochemically by use of the peroxidase-antiperoxidase (PAP) technique. Numerous paravascular and perivascular immunoreactive nerve fibers were localized around the aorta, coronary arteries and their branches down to the teminal vasculature. Arterioles in the atria showed greatest density of immunoreactive varicosities of all blood vessels. The epicardium, endocardium and the conductive system also contained numerous CGRP-IR nerve fibers. In the muocardium the number of immunoreactive varicosities was variable. Many were present in both atria, moderate amounts were seen in the right ventricle and parts of the intraventricular septum, and only a few occurred in the left ventricle. CGRP-IR was infrequently found within intracardial ganglionic cells but was abundantly distributed in the surrounding nerve fibers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00389603
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Holling's “hungry mantid” model for the invertebrate functional response considered as a Markov process. Part I: The full model and some of its limits (1985)
    Springer
    Journal of mathematical biology 22 (1985), S. 209-238 
    Details
    ISSN: 1432-1416
    Keywords: Functional response ; Structured population models ; Markov processes approximating stochastic processes ; van Kampen expansion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract In this paper we give an analytical reformulation of Holling's (1966) simulation model for invertebrate predatory behaviour. To this end we represent a population of predators as a frequency distribution over a space of (physiological) states. The functional response of a predator is calculated from the (stable) equilibrium distribution of its state as a function of prey density. Starting from the general model various other models are obtained by limit processes, some of them new and some of them old. The more interesting of which will be studied in further papers in this series.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00275716
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  • 4
    Electronic Resource
    Electronic Resource
    Holling's “hungry mantid” model for the invertebrate functional response considered as a Markov process. Part II: Negligible handling time (1985)
    Springer
    Journal of mathematical biology 22 (1985), S. 239-257 
    Details
    ISSN: 1432-1416
    Keywords: Stochastic models ; Invertebrate predation ; Functional response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract In this paper we analyse a stochastic model for invertebrate predation taking account of the predator's satiation. This model approximates Holling's “hungry mantid” model when handling time is negligible (see Part I). For this model we derive equations from which we can calculate the functional response and the variance of the total catch. Moreover we study a number of approximations which can be used to calculate these quantities in practical cases in a relatively simple manner.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00275717
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  • 5
    Electronic Resource
    Electronic Resource
    Morphological alterations and functional changes of interhepatocellular junctions induced by bile duct ligation (1977)
    Springer
    Cell & tissue research 182 (1977), S. 299-310 
    Details
    ISSN: 1432-0878
    Keywords: Liver ; Bile duct ligation (rat) ; Cell membrane ; Intercellular junctions ; Ultrastructure ; Freeze-fracturing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effect of bile duct ligation on the intercellular junctions of hepatocytes was investigated. The features and the arrangement of the bile canaliculi and the zonulae occludentes alter concomitant to the increase of the intracanalicular pressure. The lumen of the bile canaliculi enlarges and the microvilli disappear. The array of the zonulae occludentes becomes irregularly shaped, the number of strands diminishes and interruptions of the strands occur. With peroxidase a leakage in the bile-blood barrier is detected. Furthermore a disappearance of gap junctions between the hepatocytes after bile duct ligation is observed. The present investigation shows that the zonulae occludentes are mobile structures which are changed by increased unilateral pressure. Due to their ultrastructural alterations, a leakage of the permeability barrier between physiological compartments is found. We acknowledge the helpful criticism and discussion of Prof. H.D. Fahimi. We are indebted to Mrs. B. Brühl, M. Bürkle and Ch. Walenta for technical assistance, and to stud. med. Jon Greenberg for preparing the manuscript
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219766
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Reformation of gap and tight junctions in regenerating liver after cholestasis (1979)
    Springer
    Cell & tissue research 199 (1979), S. 257-270 
    Details
    ISSN: 1432-0878
    Keywords: Liver ; Bile duct ligation ; Tight junctions ; Gap junctions ; Ultrastructure ; Freeze-fracturing ; Morphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Morphometric analysis of the alterations in interhepatocyte junctions induced by bile duct ligation revealed that after 48 h, during which time the serum bilirubin increased 6 to 8 fold, the membrane area occupied by gap junctions on the apico-lateral and medio-lateral sides decreased from 3.6% in controls to 0.02% in the ligated group. The strands of the zonulae occludentes were reduced in number and showed increased discontinuities. Within 45 min of recanalization of the common bile duct, clusters of particles appeared within and adjacent to the tight junctional areas or in the lateral hepatocyte membrane. Subsequently, the particle aggregations localized in the apico-lateral membrane areas increased in number and size becoming finally indistinguishable from those of controls within 96 h after the onset of recanalization. The zonulae occludentes also rearranged and reestablished their original structure during this period. The serum bilirubin fell to normal within 24 h of recanalization. It is concluded that metabolic and ultrastructural restitution associated with the recanalization of the ligated bile duct have no strict temporal correlation to one another. These studies provide further evidence that alterations in gap and tight junctions induced by pathological processes, e.g. during bile duct ligation, are completely reversible when regeneration occurs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236137
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  • 7
    Electronic Resource
    Electronic Resource
    The auricular myocardiocytes of the heart constitute an endocrine organ characterization of a porcine cardiac peptide hormone, cardiodilatin-126 (1984)
    Springer
    Cell & tissue research 238 (1984), S. 425-430 
    Details
    ISSN: 1432-0878
    Keywords: Heart, atrium ; Myoendocrine cells ; Cardiodilatin ; Peptide hormone ; Immunohistochemistry ; Pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A peptide hormone was extracted from the porcine right atrium following a bioassay for differential vaso-relaxant effects on smooth muscle strips from aorta and renal and inferior mesenteric arteries. The isolation procedure included several steps of gel-permeation and ion-exchange chromatography, and high performance liquid chromatography. During the isolation procedure, other peptides of smaller molecular weight were also found, which, in relation to cardiodilatin-126 (CDD-126), are shorter at their N-terminal. Among these, CDD-88 has also been isolated and characterizied, and has been established as a prominent member of the cardiac hormone family. The N-terminal and C-terminal segments of the 126 amino acid-containing molecule were synthesized and used to raise region-specific antibodies. The natural peptide was then localized within myoendocrine cells of the right atrium where specific atrial granules are located. Renal effects of cardiodilation were studied in conscious dogs and showed strong diuretic and natriuretic activities. According to our functional studies, cardiodilatin-126 and cardiodilatin-88 possess qualities of a significant hormone family regarding the regulation of extracellular fluid volume and blood pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219856
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    Paper (German National Licenses)
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