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  • Spatial pattern  (2)
  • Frontal and temporal cortex  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The spatial patterns of β/A4 deposit subtypes in Alzheimer's disease (1993)
    Springer
    Acta neuropathologica 86 (1993), S. 36-41 
    Details
    ISSN: 1432-0533
    Keywords: Alzheimer's disease ; β/A4 deposits ; Morphological types ; Spatial pattern ; Clustering
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The spatial patterns of diffuse, primitive, classic (cored) and compact (burnt-out) subtypes of β/A4 deposits were studied in coronal sections of the frontal lobe and hippocampus, including the adjacent gyri, in nine cases of Alzheimer's disease (AD). If the more mature deposits were derived from the diffuse deposits then there should be a close association between their spatial patterns in a brain region. In the majority of tissues examined, all deposit subtypes occurred in clusters which varied in dimension from 200 to 6400 μm. In many tissues, the clusters appeared to be regularly spaced parallel to the pia or alveus. The mean dimension of the primitive deposit clusters was greater than those of the diffuse, classic and compact types. In about 60% of cortical tissues examined, the clusters of primitive and diffuse deposits were not in phase, i.e. they alternated along the cortical strip. Clusters of classic deposits appeared to be distributed independently of the diffuse deposit clusters. Cluster size of the primitive deposits was positively correlated with the density of the primitive deposits in a tissue but no such relationship could be detected for the diffuse deposits. This study suggested that there was a complex relationship between the clusters of the different subtypes of β/A4 deposits. If the diffuse deposits do give rise to the primitive and classic varieties then factors unrelated to the initial deposition of β/A4 in the form of diffuse plaques were important in the formation of the mature deposits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00454896
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Quantification of pathological lesions in the frontal and temporal lobe of ten patients diagnosed with Pick’s disease (1999)
    Springer
    Acta neuropathologica 97 (1999), S. 456-462 
    Details
    ISSN: 1432-0533
    Keywords: Key words Pick’s disease ; Pick bodies ; Frontal and temporal cortex ; Alzheimer’s disease ; Principal ; components analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The densities of Pick bodies (PB), Pick cells (PC), senile plaques (SP) and neurofibrillary tangles (NFT) in the frontal and temporal lobe were determined in ten patients diagnosed with Pick’s disease (PD). The density of PB was significantly higher in the dentate gyrus granule cells compared with the cortex and the CA sectors of the hippocampus. Within the hippocampus, the highest densities of PB were observed in sector CA1. PC were absent in the dentate gyrus and no significant differences in PC density were observed in the remaining brain regions. With the exception of two patients, the densities of SP and NFT were low with no significant differences in mean densities between cortical regions. In the hippocampus, the density of NFT was greatest in sector CA1. PB and PC densities were positively correlated in the frontal cortex but no correlations were observed between the PD and AD lesions. A principal components analysis (PCA) of the neuropathological variables suggested that variations in the densities of SP in the frontal cortex, temporal cortex and hippocampus were the most important sources of heterogeneity within the patient group. Variations in the densities of PB and NFT in the temporal cortex and hippocampus were of secondary importance. In addition, the PCA suggested that two of the ten patients were atypical. One patient had a higher than average density of SP and one familial patient had a higher density of NFT but few SP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010051014
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The spatial patterns of b/A4 deposit subtypes in Down's syndrome (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 353-358 
    Details
    ISSN: 1432-0533
    Keywords: Key words Alzheimer's disease ; Down's syndrome ; β/A4 deposits ; Spatial pattern ; Clustering
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The spatial patterns of diffuse, primitive and classic β/A4 deposits were studied in coronal sections of the hippocampus and adjacent gyri in 11 cases of Down's syndrome (DS) varying in age from 38 to 67 years. The objectives of the study were first, to compare the spatial patterns of β/A4 deposits revealed in DS with those reported in cases of Alzheimer's disease (AD) and second, to study how the spatial patterns of β/A4 deposits may develop in the tissue. The spatial patterns revealed in DS exhibited a number of similarities with those reported in AD: (1) the range and frequency of the different types of spatial pattern revealed were similar, (2) β/A4 deposits occurred in clusters and in many cortical tissues, the clusters were distributed in a regular pattern parallel to the pia, (3) the clusters of diffuse and primitive β/A4 deposits occurred in an alternating pattern along the cortex, and (4) the clusters of classic β/A4 deposits were not correlated with the clusters of the diffuse and primitive deposits. Primitive deposits may develop from the diffuse deposits in regions of the cortex where extracellular paired helical filaments were formed. However, clusters of the classic β/A4 deposits, which are formed in older cases, appear to develop independently of the diffuse and primitive deposits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310379
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    Paper (German National Licenses)
    Fulltext
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