ISSN:
1432-0568
Keywords:
Placenta (guinea pig)
;
Permeability
;
Freeze-Tracturing
;
Ultrastructure
;
Cell junctions
;
Tracers
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Permeability of the fetal endothelium within the guinea pig placental labyrinth is studied by means of horse-radish peroxidase (HRP) and ionic lanthanum as diffusion tracers. The paracellular transport of HRP is restricted by the occluding junctions of the fetal endothelium. In contrast, ionic lanthanum readily permeates most of the intercellular junctions and rapidly infiltrates the basal lamina. Freeze-fracture replicas reveal zonulae occludentes connecting the fetal endothelial cells. The network of the zonulae occludentes is variable, exhibiting highly complex areas as well as single strand interconnections. A correlation between the permeability studies and freeze-fracture findings is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00347018
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