ISSN:
1432-1912
Keywords:
Folic Acid
;
2,4,5-Triamino-6-styrylpyrimidme
;
Pentose Phosphate Pathway
;
Enzyme Induction
;
Nuclear RNA
;
PolsÄure
;
2,4,5-Triamino-6-styrylpyrimidin
;
Pentose-Phosphat-Weg
;
Fermentinduktion
;
Kern-RNS
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary After lesions of the proximal tubular cells, the administration of folic acid or 2,4,5-triamino-6-styrylpyrimidine increases the activity of both glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase during the regenerative phase. These increases are greater than those seen after temporary ischemia. Actinomycin and cycloheximide inhibit these processes. The triggering of natural regeneration processes by lesions is evidently enhanced by a chemical induction. The different enzymes are not induced equally during regenertion. This may be concluded from the deviating response of the activity of 3-phosphoglyceraldehyde dehydrogenase. The induction of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase demonstratedin vitro also seems to lead to an increased cell metabolismin vivo. After injection of14C-(U)-glucose, the specific activity of the RNA of isolated kidney cell nuclei after the administration of folic acid was 3 to 6 times that of the controls. The blockade of the oxidative part of the pentose phosphate pathway by 6-AN, which limits the biosynthesis of ribose by selective inhibition of 6-phosphogluconate dehydrogenase, reduces the specific activity of the nuclear RNA to 50% in animals treated with folic acid. The accumulation of 6-phosphogluconate in the kidney cells can lead to an inhibition of phosphoglucose isomerase.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00999544
Permalink
