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  • Fault location (Engineering)--Mathematical models.  (1)
  • Phosphonacetyl-L-aspartate  (1)
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  • 1
    Online Resource
    Online Resource
    Hauppauge :Nova Science Publishers, Incorporated,
    Keywords: Fault location (Engineering)--Mathematical models. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (156 pages)
    Edition: 1st ed.
    ISBN: 9781536103595
    Series Statement: Systems Engineering Methods, Developments and Technology
    DDC: 551.87202839999998
    Language: English
    Note: Intro -- FAULT DETECTION METHODS, APPLICATIONS AND TECHNOLOGY -- FAULT DETECTION METHODS, APPLICATIONS AND TECHNOLOGY -- CONTENTS -- PREFACE -- Chapter1ACTIVEFAULTDETECTIONINNONLINEARDIFFERENTIALALGEBRAICEQUATIONSI:GENERALSYSTEMS -- Abstract -- 1.Introduction -- 2.ReviewofLinearDAEApproach -- 3.GeneralNonlinearApproach -- 4.HessenbergSystems -- 5.CaseStudy -- 5.1.SolvingtheNonlinearProblem -- Conclusion -- Acknowledgment -- References -- Chapter2ACTIVEFAULTDETECTIONINNONLINEARDIFFERENTIALALGEBRAICEQUATIONSII:USINGLINEARIZATIONS -- Abstract -- 1.Introduction -- 2.ReviewofLinearDAEApproach -- 3.CaseStudy -- 3.1.Linearization -- 4.EvaluationoftheTestSignal -- 5.ModelIdentificationwithNonlinearModels -- Conclusion -- Acknowledgment -- References -- Chapter 3 SEISMIC ATTRIBUTE-AIDED FAULT DETECTION IN PETROLEUM INDUSTRY: A REVIEW -- Abstract -- Introduction -- Attribute Extraction -- Data Preconditioning -- Median Filter -- Edge-Preserving Smoothing -- Discontinuity Analysis -- Coherence -- Sobel Filtering -- Semblance -- Similarity -- Canny Edge Detection -- Fault Enhancement -- Ant Tracking -- Lineament Thinning -- Fault Mapping -- Manual Fault Picking -- Semi-Automatic Fault Extraction -- Automatic Fault Extraction -- Fault Map Quality Control -- Future Work -- Conclusion -- Acknowledgments -- References -- Biographical Sketches -- Haibin Di -- Research and Professional Experience -- Publications Last Three Years -- Journal Publications (9) -- Conference Presentations (8) -- Dengliang Gao -- Research and Professional Experience -- Publications Last Three Years: -- Chapter 4 SELF-ADAPTIVE EXPERT SYSTEM FOR PROCESS MONITORING AND FAULT DETECTION -- Abstract -- 1. Introduction -- 2. Informational Potential -- 3. Potential Based Recursive Clustering Algorithm. , Listing 1. Pseudo-Code of the Proposed Potention Based Recursive Clustering Procedure (PBRC) -- 4. Specialization of the PBRC Algorithm for FDI -- 5. System Testing and Results -- Data Collecting -- Signal Processing and Extraction of Characteristic Features -- Fuzzy Logic of Middle Layer -- Fuzzy Logic of Output Layer -- Conclusion -- References -- Biographical Sketch -- Milena Petkovic, PhD -- Chapter 5 AN INTEGRATED FDD SYSTEM FOR HVAC& -- R BASED ON VIRTUAL SENSORS -- Abstract -- Introduction -- Review of Virtual Sensors -- Benefits of Virtual Sensors -- General Steps for Developing Virtual Sensors -- Overview of Virtual Sensor Developments in Other Fields -- Virtual Sensing in Automobiles -- Virtual Sensing in Control Systems -- Development of FDD System Based on Virtual Sensor for HVAC& -- R -- Sensor Level Virtual Sensor -- Component Level Virtual Sensor -- Virtual Refrigerant Mass Flow Sensor -- Virtual Air Flow Rate Sensor -- System Level Virtual Sensor -- Virtual Refrigerant Charge Sensor -- Virtual Performance Sensor -- Integration of Virutal Sensors -- Fault Impact Model -- Validation of FDD System Based on Virutal Sensor for HVAC& -- R -- System Description and Test Conditions -- Virtual Sensor Peformance Evaluation -- Validation of Virtual Refrigerant Charge Sensor -- Validation of Virtual Refrigerant Mass Flow Sensor -- Validation of Virtual Air Flow Rate Sensor -- Fault Impact Model Evaluation -- Embedded FDD System Based on Virtual Sensor -- User Interface Development -- Virtual Sensor Implementation -- Conclusion -- References -- Biographical Sketch -- Woohyun Kim -- Research and Professional Experience -- Professional Appointments -- Honors -- Publications -- INDEX.
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  • 2
    ISSN: 1432-0843
    Keywords: 5-Fluorouracil ; Phosphonacetyl-L-aspartate ; b-Methylmercaptopurine riboside ; Combination treatment ; Pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Inhibition of pyrimidine and purine synthesis has been demonstrated to potentiate 5-fluorouracil (5-FU) activity in preclinical models. Low-dose phosphonacetyl-l-aspartate (PALA) potentiates the incorporation of 5-FU into RNA, without detectably increasing its toxicity. 6-Methylmercaptopurine riboside (MMPR) results in inhibition of purine biosynthesis with elevation of phosphoribosyl pyrophosphate (PRPP), which in turn is believed to increase the phosphorylation and intracellular retention of 5-FU. We conducted a phase I clinical trial to determine the maximum tolerated dose of 5-FU in combination with low-dose PALA and a biochemically-optimized dose of MMPR. The regimen consisted of PALA 250 mg/m2 given on day 1, followed 24 h later by MMPR 150 mg/m2, and escalating doses of 5-FU from 1625 to 2600 mg/m2 by 24 h continuous infusion. This regimen was repeated weekly. A group of 29 patients with a diagnosis of malignant solid tumor were entered; their median performance status was 1. The dose-limiting toxicity was mucositis, while other gastrointestinal toxicity was minimal. Two patients also experienced ischemic chest pain during the 5-FU infusion. The maximum tolerated dose of 5-FU in this combination was 2600 mg/m2. Several responses were observed including a complete remission in a previously treated breast cancer patient and two partial responses in breast and colon cancer. MMPR pharmacokinetics were obtained from urine analyses in 21 patients on this trial; there was no correlation between the pharmacokinetics of MMPR and the toxicity observed. This regimen was well tolerated and phase II trials are warranted using PALA 250 mg/m2, MMPR 150 mg/m2, and 5-FU 2300 mg/m2 by continuous infusion over 24 h.
    Type of Medium: Electronic Resource
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