ISSN:
1439-6327
Keywords:
Metabolic alkalosis
;
Exercise
;
Muscle fatigue
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Six thoroughbred horses exercised on a motorised treadmill on two separate occasions at a speed of 11 or 12 m· s−1 for up to 2 min. 4 h prior to exercise each horse was given a 21 test solution of sodium bicarbonate (NaHC03; 0.6 g·kg−1 body mass) or a control solution of water by nasogastric intubation, the order of administration of the two solutions was randomised. Blood samples (n=15) were obtained before and during the 4 h after intubation, during exercise and for 30 min after exercise. (NaHC03; ingestion resulted in changes in pre-exercise acid-base status. The changes in blood lactate and base excess with exercise were greater after (NaHC03; administration; after 1 min of exercise in the case of lactate (P〈0.05) and immediately after exercise in the case of base excess (P〈0.05). Plasma ammonia levels were lower during (P〈0.05) and immediately after (P〈0.05) exercise following (NaHC03; ingestion. The peak change in plasma ammonia with exercise was also lower after (NaHC03; ingestion (P〈0.05). Following exercise after (NaHC03; ingestion, five horses demonstrated lower muscle adenosine 5-triphosphate loss (P〈0.05) and inosine 5-monophosphate formation (P=0.05) and higher glycerol 3-phosphate formation (P〈0.05). There is evidence to suggest that metabolic alkalosis may delay the onset of fatigue by decreasing the extent of adenine nucleotide loss during high-intensity exercise.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00235182
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