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  • 1
    Electronic Resource
    Electronic Resource
    The charge-state model of protein polymorphism in natural populations (1975)
    Springer
    Journal of molecular evolution 6 (1975), S. 149-163 
    Details
    ISSN: 1432-1432
    Keywords: Electrophoretic Detectability ; Neutral Mutation Theory ; Evolution ; Mutation Rates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Routine electrophoretic surveys for genetic variation in natural populations depend primarily upon detecting differences in the net charge carried by a protein. We have calculated the proportion of base substitutions which would yield an electrophoretically detectable mutant protein, and the relative mutation rates among different charge classes, under a variety of simplifying assumptions. These calculations indicate that: (i) only 25 per cent of all single base mutations would lead to a charge change on a protein molecule. (ii) five distinct classes of electrophoretic variants can be generated from a specified protein by single base substitutions. (iii) the relative mutation rates differ markedly among the different charge classes which can be generated by single base substitutions. The estimates of the proportion of electrophoretically detectable mutant proteins and relative mutation rates among charge classes were relatively robust to changes in assumptions concerned with the kind and site of base substitutions and the amino acid composition of the protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01732353
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Multiline varieties and disease control (1985)
    Springer
    Theoretical and applied genetics 69 (1985), S. 463-474 
    Details
    ISSN: 1432-2242
    Keywords: Multiline varieties ; Disease control ; “Dirty crop” approach ; Evolution ; Pathogens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A general model for the evolution of pathogen populations on mixtures or multilines is developed. This model is used to extend previous analyses of the effects of the widespread cultivation of multilines on the evolution of virulence in obligate parasites to mixtures of lines carrying different numbers of resistance genes. It is concluded that the composition of an equilibrium pathogen population growing on a multiline may vary within wide limits and the prinicipal determinant of its composition is the number of components in the multiline and the resistance genes they carry. Other factors of importance are (i) the relative contribution made by each host class (with different numbers of resistance genes) to the pathogen spore pool each generation; (ii) the levels of ‘stabilizing selection’ against unnecessary virulence genes; and (iii) the way in which unnecessary genes for virulence combine to reduce pathogen fitness. Conditions for the fixation of avirulent biotypes in the pathogen population and the evolution of a pathogen superrace are given for multilines of various compositions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251086
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Multiline varieties and disease control (1986)
    Springer
    Theoretical and applied genetics 71 (1986), S. 801-809 
    Details
    ISSN: 1432-2242
    Keywords: Multiline varieties ; Disease control ; “Dirty crop” approach ; Evolution ; Pathogens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Existing theoretical models have led to conflicting predictions concerning the likely effect of the widespread use of dirty crop multilines on the evolution of virulence in pathogen populations. Here we attempt to clarify these problems by extending existing models to include selection against unnecessary genes for virulence at two different stages in the life cycle of the pathogen. The results of these studies indicate that the stage of the life cycle at which selection occurs can significantly influence the evolution of virulence in pathogen populations growing on multiline varieties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00276421
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    Paper (German National Licenses)
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