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  • Evolution  (1)
  • human β globin  (1)
  • 1
    Electronic Resource
    Electronic Resource
    A comparison of theβ A- andβ B-globin gene clusters of sheep (1989)
    Springer
    Journal of molecular evolution 28 (1989), S. 175-184 
    Details
    ISSN: 1432-1432
    Keywords: Sheep ; Globin genes ; Evolution ; Gene duplication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Domestic sheep have two common alleles at the adult β-globin locus,β A andβ B. Here we report the structure of the β-globin locus of A-haplotype sheep. The locus consists of 12 genes, organized as a triplicated 4-gene set: 5′ ∈I-∈II-ΨβI-βC-∈III-∈IV-ΨβII-βA-∈V-∈VI-ΨβIII-βF 3′. This arrangement is identical to that of the closely related goat locus. Sheep with the B haplotype have a locus arrangement consisting of a duplicated four-gene set, lacking the βC gene as well as three other genes present in A sheep and goats. In order to understand the evolutionary history of the B sheep locus, we have sequenced the βB gene from these sheep, and the βB gene from A-haplotype sheep, and compared the sequences to those of the sheep βA, goat βC, and βA, and cow adult β genes. Our results indicate that the βB gene has diverged recently from the βA gene, and therefore the βB locus structure may have resulted from a recent deletion from a triplicated locus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02102474
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Analysis of developmental switching in transgenic mice with 5′ and 3′ deletions in the human β globin gene (1996)
    Springer
    Transgenic research 5 (1996), S. 245-255 
    Details
    ISSN: 1573-9368
    Keywords: human β globin ; 3′ enhancer ; transgenic ; promoter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Our interest in thecis-acting elements that promote the up-regulation of the β globin gene has led to a systematic deletion analysis of portions of the β globin gene in the context of the HS2 and γ globin gene using transgenic mice. In constructs that delete the 5′ region to only 265 bp, high-level erythroid-specific expression was observed. Further deletion to 122 bp, however, results in significantly reduced expression levels A substitution of a minilocus control region for the single HS2 site was also produced, resulting in increased β globin expression over that seen with the HS2 alone. These results are consistent with the presence of an enhancer-like element between −122 and −265. In addition, a construct in which the entire β globin gene promoter was replaced by a thymidine kinase promoter was tested. Interestingly, no expression was detected in these transgenic mice. This may indicate the requirement for an erythroid-specific promoter to drive this gene. Finally, the 3′ region of the β globin gene was deleted in order to examine the effect of a previously defined 3′ enhancer region. With deletion of this region, the expression of the human β globin gene in transgenic mice is unchanged relative to the parental constructs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972878
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    Paper (German National Licenses)
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