Note: Front Cover -- Molecular Architecture of Proteins and Enzymes -- Copyright Page -- Table of Contents -- Contributors -- Preface -- Part I: Structure and Function Relationships of Proteins -- CHAPTER 1. SYNTHETIC MODELS OF THE METASTABLE BINDING SITES OF ALPHA-2 MACROGLOBULIN AND COMPLEMENT COMPONENTS C3 AND C4 -- STRUCTURES PROPOSED FOR THE METASTABLE BINDING SITE -- INTERCONVERSION OF THE SYNTHETIC PEPTIDE MODELS -- COMPETITIVE KINETICS OF ISOMERIZATION AND HYDROLYSIS -- REGIOSELECTIVE HYDROLYSIS OF INTERNAL PYROGLUTAMIC ACID RESIDUES -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 2. KINETICS OF IRREVERSIBLE MODIFICATION OF ENZYME ACTIVITY -- RATE EQUATIONS FOR THE BINDING OF THE MODIFIER TO THE ENZYME -- COMPETITION BETWEEN THE MODIFIER AND THE SUBSTRATE -- SUBSTRATE REACTION IN THE PRESENCE OF THE MODIFIER -- DIFFERENTIATION OF DIFFERENT TYPES OF INHIBITION -- IRREVERSIBLE INHIBITION COMPLEXES -- SUBSTRATE REACTION DURING ENZYME ACTIVATION -- CONCLUDING REMARKS -- ACKNOWLEDGMENT -- REFERENCES -- CHAPTER 3. STRUCTURE AND MECHANISM OF DOPAMINE β-HYDROXYLASE -- Cu BINDING AND STOICHIOMETRY -- MECHANISM-BASED INHIBITORS -- STRUCTURE-FUNCTION STUDIES -- REFERENCES -- CHAPTER 4. STUDIES ON SNAKE MUSCLE FRUCTOSE 1,6-BISPHOSPHATASE -- PURIFICATION -- K+-ACTIVATION KINETICS -- CHEMICAL MODIFICATION -- INHIBITION OF AMP ANALOGS -- COLD INACTIVATION -- LIMITED PROTEOLYSIS -- REFERENCES -- CHAPTER 5. THREE-DIMENSIONAL STRUCTURES OF SCORPION NEUROTOXINS -- VARIANT-3 TOXIN -- VARIANT-2 TOXIN -- TOXIN V -- APAMIN -- SUMMARY AND CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 6. THE RAPID INACTIVATION AND SLOW CONFORMATIONAL CHANGES OF CREATINE KINASE DURING GUANIDINE AND UREA DENATURATION -- THE DENATURATION OF CREATINE KINASE -- INACTIVATION OF CREATINE KINASE IN GUANIDINE. , CORRELATION OF CONFORMATIONAL CHANGES OF CREATINE KINASE DURING DENATURATION -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 7. NUCLEAR MAGNETIC RESONANCE FOR THE STUDY OF PROTEIN STRUCTURE -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- ACKNOWLEDGEMENTS -- REFERENCES -- CHAPTER 8. STRUCTURAL AND FUNCTIONAL PROPERTIES OF -- CRYSTALLIZATION AND PROPERTIES OF L-ASPARAGINASE -- POLYMERS AND SUBUNITS OF L-ASPARAGINASE -- EFFECTS OF L-CYSTEINE ON THE ACTIVITY AND CONFORMATION OF L-ASPARAGINASE -- REFERENCES -- Part II: Regulation of Biological Process -- CHAPTER 9. CRYSTALLOGRAPHIC STUDIES ON INSULIN AND ITS ANALOGS -- THE REFINEMENT OF THE STRUCTURE OF 2 Zn PORCINE INSULIN AT 1.2 Ả RESOLUTION -- PRELIMINARY STUDIES ON SOME INSULIN ANALOGS BY X-RAY CRYSTALLOGRAPHY -- THE MONOMERIC STRUCTURE OF DES-PENTAPEPTIDE-(B26-30)-INSULIN (DPI) -- REFERENCES -- CHAPTER 10. PEPTIDE-RECEPTOR INTERACTIONS THAT REGULATE CELL PROLIFERATION: THE EPIDERMAL GROWTH FACTOR SYSTEM -- EPIDERMAL GROWTH FACTOR AND CELL PROLIFERATION -- BINDING OF EGF TO SPECIFIC MOLECULES AT THE CELL SURFACE -- EGF-STIMULATION OF PROTEIN PHOSPHORYLATION -- EFFECT OF TEMPERATURE ON PHOSPHORYLATION OF A-43I MEMBRANES -- RECEPTOR STRUCTURE -- PROSPECTUS -- REFERENCES -- CHAPTER 11. STUDIES ON STRUCTURE AND BIOLOGICAL ACTIVITY OF INSULIN -- EFFECT OF THE SHORTENED B-CHAIN ON THE ACTIVITY OF INSULIN -- EFFECT OF SUBSTITUTION OF THE ε-AMINO GROUP IN B29-LYS ON ACTIVITY OF INSULIN -- PREPARATION AND PROPERTIES OF HUMAN INSULIN -- CONCLUSIONS -- REFERENCES -- CHAPTER 12. CHOLESTEROL INTERACTION WITH AND INFLUENCE ON FUNCTION OF THE NICOTINIC ACETYLCHOLINE RECEPTOR -- RESULTS -- DISCUSSION -- REFERENCES -- CHAPTER 13. TCELL CONTROL OF IMMUNOGLOBULIN SYNTHESIS -- B CELL ACTIVATION AND PROLIFERATION -- B CELL DIFFERENTIATION -- CONCLUDING REMARKS -- ACKNOWLEDGMENTS -- REFERENCES. , CHAPTER 14. THE DISSOCIATION AND REASSEMBLY OF VIRAL CAPSIDE -- DISSOCIATION AND REASSEMBLY OF ROD-SHAPED AND ISOMETRIC VIRUSES -- REASSEMBLY OF THE PROTEIN SUBUNITS OF AN ISOMETRIC VIRUS INTO ROD-SHAPED HELICAL CAPSID STRUCTURE -- REFERENCES -- Part III: Structure and Function Relationships of Blood Proteins -- CHAPTER 15. MOLECULAR STRUCTURE OF PLASMA PROTEASE INHIBITOR GENES IN MAN -- ANTITHROMBIN III -- α 1-ANTITRYPSIN -- α 1-ANTICHYMOTRYPSIN -- SEQUENCE HOMOLOGY BETWEEN HUMAN α1-ANTICHYMOTRYPSIN, α1 - ANTITRYPSIN AND ANTITHROMBIN III -- COMPARISON OF ACTIVE SITE SEQUENCES OF THE THREE PLASMA PROTEASE INHIBITORS -- CONCLUDING REMARKS -- REFERENCES -- CHAPTER 16. THE POLYMORPHISM OF SOME SERUM PROTEINS IN THE CHINESE POPULATION -- SERUM ALBUMIN -- TRANSFERRIN -- HAPTOGLOBIN -- CERULOPLASMIN -- α-1-ANTITRYPSIN -- REFERENCES -- CHAPTER 17. STUDIES ON A NEW THROMBIN DEPENDENT ANTICOAGULANT PATHWAY -- A FUNCTIONAL ASSAY FOR PROTEIN C -- EXPRESSION OF ANTICOAGULANT ACTIVITY -- SUMMARY -- REFERENCES -- CHAPTER 18. ACTION OF ANTITHROMBOPLASTIN FROM AGKISTRODON HALYS (PALLAS) VENOM ON BLOOD COAGULATION SYSTEM -- THE ACTION OF THE CRUDE VENOM ON BLOOD COAGULATION SYSTEM -- THE ACTION OF THE ANTICOAGULANT PRINCIPLE ON BLOOD COAGULATION SYSTEM -- HYDROLYSIS OF PLASMA PHOSPHOLIPIDS BY THE ANTICOAGULANT PRINCIPLE -- ACTION OF THE ANTICOAGULANT PRINCIPLE ON MEMBRANE PHOSPHOLIPIDS OF INTACT RED CELLS AND INTACT PLATELETS -- MORPHOLOGICAL CHANGES OF RED CELLS AND PLATELETS INDUCED BY THE ANTICOAGULANT PRINCIPLE -- NEUTRALIZATION OF THE ANTICOAGULANT ACTION OF THE PRINCIPLE BY ANTI-AGKISTRODON HALYS (PALLAS) VENOM SÉRUM -- ACKNOWLEDGMENTS -- REFERENCES -- Index.

Note: Front Cover -- Molecular Architecture of Proteins and Enzymes -- Copyright Page -- Table of Contents -- Contributors -- Preface -- Part I: Structure and Function Relationships of Proteins -- CHAPTER 1. SYNTHETIC MODELS OF THE METASTABLE BINDING SITES OF ALPHA-2 MACROGLOBULIN AND COMPLEMENT COMPONENTS C3 AND C4 -- STRUCTURES PROPOSED FOR THE METASTABLE BINDING SITE -- INTERCONVERSION OF THE SYNTHETIC PEPTIDE MODELS -- COMPETITIVE KINETICS OF ISOMERIZATION AND HYDROLYSIS -- REGIOSELECTIVE HYDROLYSIS OF INTERNAL PYROGLUTAMIC ACID RESIDUES -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 2. KINETICS OF IRREVERSIBLE MODIFICATION OF ENZYME ACTIVITY -- RATE EQUATIONS FOR THE BINDING OF THE MODIFIER TO THE ENZYME -- COMPETITION BETWEEN THE MODIFIER AND THE SUBSTRATE -- SUBSTRATE REACTION IN THE PRESENCE OF THE MODIFIER -- DIFFERENTIATION OF DIFFERENT TYPES OF INHIBITION -- IRREVERSIBLE INHIBITION COMPLEXES -- SUBSTRATE REACTION DURING ENZYME ACTIVATION -- CONCLUDING REMARKS -- ACKNOWLEDGMENT -- REFERENCES -- STRUCTURE AND MECHANISM OF DOPAMINE β-HYDROXYLASE1 -- CHAPTER 3. Cu BINDING AND STOICHIOMETRY -- MECHANISM-BASED INHIBITORS -- STRUCTURE-FUNCTION STUDIES -- REFERENCES -- CHAPTER 4. STUDIES ON SNAKE MUSCLE FRUCTOSE 1,6-BISPHOSPHATASE -- PURIFICATION -- K+-ACTIVATION KINETICS -- CHEMICAL MODIFICATION -- INHIBITION OF AMP ANALOGS -- COLD INACTIVATION -- LIMITED PROTEOLYSIS -- REFERENCES -- CHAPTER 5. THREE-DIMENSIONAL STRUCTURES OF SCORPION NEUROTOXINS1 -- VARIANT-3 TOXIN -- VARIANT-2 TOXIN -- TOXIN V -- APAMIN -- SUMMARY AND CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 6. THE RAPID INACTIVATION AND SLOW CONFORMATIONAL CHANGES OF CREATINE KINASE DURING GUANIDINE AND UREA DENATURATION -- THE DENATURATION OF CREATINE KINASE -- INACTIVATION OF CREATINE KINASE IN GUANIDINE -- ACKNOWLEDGMENTS -- REFERENCES. , CHAPTER 7. NUCLEAR MAGNETIC RESONANCE FOR THE STUDY OF PROTEIN STRUCTURE1 -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- ACKNOWLEDGEMENTS -- REFERENCES -- CHAPTER 8. STRUCTURAL AND FUNCTIONAL PROPERTIES OF E. COLI L-ASPARAGINASE -- CRYSTALLIZATION AND PROPERTIES OF L-ASPARAGINASE -- POLYMERS AND SUBUNITS OF L-ASPARAGINASE -- EFFECTS OF L-CYSTEINE ON THE ACTIVITY AND CONFORMATION OF L-ASPARAGINASE -- REFERENCES -- Part II: Regulation of Biological Process -- CHAPTER 9. CRYSTALLOGRAPHIC STUDIES ON INSULIN AND ITS ANALOGS -- THE REFINEMENT OF THE STRUCTURE OF 2 Zn PORCINE INSULIN AT 1.2 Ä RESOLUTION -- PRELIMINARY STUDIES ON SOME INSULIN ANALOGS BY X-RAY CRYSTALLOGRAPHY -- THE MONOMERIC STRUCTURE OF DES-PENTAPEPTIDE-(B26-30)INSULIN (DPI) -- REFERENCES -- CHAPTER 10. PEPTIDE-RECEPTOR INTERACTIONS THAT REGULATE CELL PROLIFERATION: THE EPIDERMAL GROWTH FACTOR SYSTEM -- EPIDERMAL GROWTH FACTOR AND CELL PROLIFERATION -- BINDING OF EGF TO SPECIFIC MOLECULES AT THE CELL SURFACE -- EGF-STIMULATION OF PROTEIN PHOSPHORYLATION -- EFFECT OF TEMPERATURE ON PHOSPHORYLATION OF A-43I MEMBRANES -- RECEPTOR STRUCTURE -- PROSPECTUS -- REFERENCES -- CHAPTER 11. STUDIES ON STRUCTURE AND BIOLOGICAL ACTIVITY OF INSULIN -- EFFECT OF THE SHORTENED B-CHAIN ON THE ACTIVITY OF INSULIN -- EFFECT OF SUBSTITUTION OF THE ε-ΑΜΙΝΟ GROUP IN B29-LYS ON ACTIVITY OF INSULIN -- PREPARATION AND PROPERTIES OF HUMAN INSULIN -- CONCLUSIONS -- REFERENCES -- CHAPTER 12. CHOLESTEROL INTERACTION WITH AND INFLUENCE ON FUNCTION OF THE NICOTINIC ACETYLCHOLINE RECEPTOR -- RESULTS -- DISCUSSION -- REFERENCES -- CHAPTER 13. T CELL CONTROL OF IMMUNOGLOBULIN SYNTHESIS1 -- B CELL ACTIVATION AND PROLIFERATION -- B CELL DIFFERENTIATION -- CONCLUDING REMARKS -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 14. THE DISSOCIATION AND REASSEMBLY OF VIRAL CAPSIDE. , DISSOCIATION AND REASSEMBLY OF ROD-SHAPED AND ISOMETRIC VIRUSES -- REASSEMBLY OF THE PROTEIN SUBUNITS OF AN ISOMETRIC VIRUS INTO ROD-SHAPED HELICAL CAPSID STRUCTURE -- REFERENCES -- Part III: Structure and Function Relationships of Blood Proteins -- CHAPTER 15. MOLECULAR STRUCTURE OF PLASMA PROTEASE INHIBITOR GENES IN MAN1 -- ANTITHROMBIN III -- α 1-ANTITRYPSIN -- α 1-ANTICHYMOTRYPSIN -- SEQUENCE HOMOLOGY BETWEEN HUMAN α1-ANTICHYMOTRYPSIN, α1- ANTITRYPSIN AND ANTITHROMBIN III -- COMPARISON OF ACTIVE SITE SEQUENCES OF THE THREE PLASMA PROTEASE INHIBITORS -- CONCLUDING REMARKS -- REFERENCES -- CHAPTER 16. THE POLYMORPHISM OF SOME SERUM PROTEINS IN THE CHINESE POPULATION -- SERUM ALBUMIN -- TRANSFERRIN -- HAPTOGLOBIN -- CERULOPLASMIN -- α-1-ANTITRYPSIN -- REFERENCES -- CHAPTER 17. STUDIES ON A NEW THROMBIN DEPENDENT ANTICOAGULANT PATHWAY -- A FUNCTIONAL ASSAY FOR PROTEIN C -- EXPRESSION OF ANTICOAGULANT ACTIVITY -- SUMMARY -- REFERENCES -- CHAPTER 18. ACTION OF ANTITHROMBOPLASTIN FROM AGKISTRODON HALYS (PALLAS) VENOM ON BLOOD COAGULATION SYSTEM -- THE ACTION OF THE CRUDE VENOM ON BLOOD COAGULATION SYSTEM -- THE ACTION OF THE ANTICOAGULANT PRINCIPLE ON BLOOD COAGULATION SYSTEM -- HYDROLYSIS OF PLASMA PHOSPHOLIPIDS BY THE ANTICOAGULANT PRINCIPLE -- ACTION OF THE ANTICOAGULANT PRINCIPLE ON MEMBRANE PHOSPHOLIPIDS OF INTACT RED CELLS AND INTACT PLATELETS -- MORPHOLOGICAL CHANGES OF RED CELLS AND PLATELETS INDUCED BY THE ANTICOAGULANT PRINCIPLE -- NEUTRALIZATION OF THE ANTICOAGULANT ACTION OF THE PRINCIPLE BY NSTI-AGKISTRODON HALYS (PALLAS) VENOM SERUM -- ACKNOWLEDGMENTS -- REFERENCES -- Index.