ISSN:
1573-739X
Keywords:
Beclomethasone
;
Chromatography, high pressure liquid
;
Chromatography, thin layer
;
Drug compounding
;
Drug stability
;
Enema
;
Mesalazine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A beclomethasone dipropionate (BDP) enema and a BDP/mesalazine combination enema (containing 2 mg BDP and 1 g mesalazine and 2 mg BDP, respectively per 40 ml) were formulated. BDP and mesalazine were suspended in a carbomer-water gel. No degradation of BDP was measured during the storage period of the BDP enema (4 weeks at 20°C) and of the BDP/mesalazine enema (44 days at 4°C, 20°C and 37°C, respectively). Progressive darkening of colour occurred for the BDP/mesalazine enema during storage at 20°C and at 37°C, probably induced by mesalazine degradation products. Only very slight colouring was observed at 4°C. Hardly any precipitation of BDP and mesalazine was seen during the storage period and the enemas could easily be resuspended.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01972910
Permalink
