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  • Electronic structure and strongly correlated systems  (1)
  • Gene expression  (1)
  • Multiple system  (1)
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  • 1
    ISSN: 1432-0533
    Keywords: Key words NACP ; Synuclein ; Multiple system ; atrophy ; Neuronal cytoplasmic inclusions ; Glial ; cytoplasmic inclusions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined neuronal cytoplasmic inclusions (NCIs) and oligodendrocytic glial cytoplasmic inclusions (GCIs) in the pontine nuclei in multiple system atrophy (MSA) using antibodies against the non-amyloid β component of Alzheimer’s disease amyloid precursor protein (NACP/α-synuclein). Our immunohistochemical study revealed that anti-NACP antibodies labeled both NCIs and GCIs. Immunoelectron microscopy showed that positive reaction products were localized on the 15- to 30-nm-thick filamentous components of NCIs and GCIs. The present study demonstrates that NACP is associated with cytoplasmic inclusions of MSA, and suggests a role of NACP in abnormal filament aggregation in neuronal degeneration.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1617-4623
    Keywords: A-factor ; Streptomyces griseus ; Streptomycin biosynthesis ; Streptomycin resistance ; Gene expression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A-factor (2-isocapryloyl-3R-hydroxymethyl-γ-butyrolactone) is a microbial hormone controlling streptomycin (Sm) production, Sm resistance and sporulation in Streptomyces griseus. In order to identify A-factor-dependent promoters in the Sm biosynthetic gene cluster, a new promoter-probe plasmid with a low copy number was constructed by using an extremely thermostable malate dehydrogenase gene as the reporter. Of the three promoters in the Sm production region that includes strR, aphD and strB, only the promoter of strR, which codes for a putative regulatory protein, was found to be directly controlled by A-factor. This was also confirmed by S1 nuclease mapping. The region essential for its A-factor-dependence was determined to be located 430–330 base pairs upstream of the transcriptional start point. Increase in the copy number of the strR promoter region did not lead to a corresponding increase in the total promoter activity, probably due to titration of a putative activator which binds to the enhancer-like region and controls the expression of the strR promoter. This putative activator is apparently distinct from the A-factor-receptor protein. The aphD gene, which encodes the major Sm resistance determinant, Sm-6-phosphotransferase, was transcribed mainly by read-through from the A-factor-dependent strR promoter; this accounts for the prompt induction of Sm resistance by A-factor.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2018-03-23
    Description: Author(s): Touru Yamauchi, Hiroaki Ueda, Kenji Ohwada, Hironori Nakao, and Yutaka Ueda A novel phase transition with a stepwise evolution of odd-number charge modulation is discovered in β -vanadium bronzes under pressures of about 1 GPa. All the charge modulation vectors of the many kinds of charge-ordered phases can be represented as a primitive lattice translation vector along the b axis multiplied by several odd numbers. This discovery demonstrates interplay between the charge degree of freedom and the crystallographic symmetry. This phenomenon is rationally explained by self-charge transfer (carrier redistribution) between two kinds of subsystems in the structure and sequential symmetry reduction as outlined in Landau theory of phase transitions. [Phys. Rev. B 97, 125138] Published Thu Mar 22, 2018
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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