Note: Cover -- Contents -- Preface -- Introduction -- Chapter 1: Speakers at the Symposium -- Thomas Braun, MD -- Tao Cheng, MD -- James DeGregori, PhD -- Gerald de Haan, PhD -- Ronald A. DePinho, MD -- Kenneth Dorshkind, PhD -- Toren Finkel, MD, PhD -- Hartmut Geiger, PhD -- Margaret A. Goodell, PhD -- D. Leanne Jones, PhD -- Zhenyu Ju, MD, PhD -- Sean J. Morrison, PhD -- Hiromitsu Nakauchi, MD, PhD -- Andre Nussenzweig, PhD -- Thomas A. Rando, MD, PhD -- Tannishtha Reya, PhD -- Hans-Reimer Rodewald, PhD -- Derrick J. Rossi, PhD -- Karl Lenhard Rudolph, MD -- Norman E. Sharpless, MD -- Toshio Suda, MD -- Andreas Trumpp, PhD -- Maarten van Lohuizen, PhD -- Gary Van Zant, PhD -- Amy J. Wagers, PhD -- Irving L. Weissman, MD -- Ting Xie, PhD -- Chapter 2: Hematopoietic Stem Cell Aging and Fate Decision -- Abstract -- Characteristics of Hematopoietic Stem Cells -- Functional Changes during Aging -- Immuno-Phenotype Changes during Aging -- Epigenetic Regulation of Stem Cell Function -- DNA Damage Signaling in the Regulation ofHSCs -- Dissecting Age-Dependent Effects on Hematopoiesis in Recombinant Inbred Mouse Strains -- Genes Controlling HSC Quiescence and Self-Renewal -- Regulation of Dormant HSCs -- Summary -- References -- Chapter 3: Alterations of Systemic Environment Impair Stem Cell Function during Aging -- Abstract -- Introduction -- Macroenvironmental Alterations Regulate HSC Function -- Macroenvironmental Alterations Regulate SMP Function -- Macroenvironmental Aging Characterized by Alterations of Circulatory Factors -- DNA Damage and Telomere Dysfunction Induce Age-Dependent Secretion ofv Circulating Factors -- References -- Chapter 4: Novel Insights into Regulation of Stem Cell Aging by Aging of the Niche and Alterations in Systemic Factors -- Abstract -- Aging of Muscle Stem Cells Is Reversible. , Hematopoietic Stem Cells Can Be Rejuvenated by Systemic Factors -- Adhesion Is Central to Stem Cell Niche Interactions -- Drosophila Germ Line Stem Cells and Their Niche -- References -- Chapter 5: Aging and Hematopoietic Malignancies -- Abstract -- Loss of Proliferative Capacity of Hematopoietic Cells Can Accelerate Leukemogenesis -- Leukemic Cells Evade the Immune System -- Patterns of Cell Divisions in Leukemia -- References -- Chapter 6: Intestinal Stem Cell Aging -- Abstract -- Intestinal Epithelium -- Intestinal Stem Cells -- Molecular Control of Cell Proliferation and Organ Maintenance in the Intestine -- Age-Associated Diseases of the Intestine -- Mechanisms of Intestinal Stem Cell Aging in Model Systems -- Outlook -- References -- Chapter 7: Molecular Mechanisms of Aging in Muscle Stem Cells -- Abstract -- Morphological and Molecular Properties of Muscle Stem Cells -- Molecular Mechanisms of Satellite Cell Aging -- Epigenetic Regulation of Myogenic Stem Cells during Aging -- Conclusions and Perspectives -- References -- Chapter 8: Free Radicals and Stem Cell Aging -- Abstract -- Reactive Oxygen Species and Aging -- Stem Cell Aging and Oxidative Stress -- Control of ROS Production in Stem Cells -- Conclusions -- References -- Chapter 9: DNA Damage, Checkpoint Responses, and Cell Cycle Control in Aging Stem Cells -- Abstract -- Hematopoietic Stem Cells Are More Resistant to DNA Damage Responses and Accumulate More DNA Damage than Hematopoietic Progenitor Cells -- Inactivation of PUMA Protects Stem Cells in Response to Irradiation-Induced DNA Damage -- p53-Dependent Depletion of Chromosomally Unstable Stem Cells Can Protect Tissues from Age-Related Atrophy in the Context of Telomere Dysfunction -- Chk2-Dependent Checkpoints Limit Progenitor Cell Function in Response to DNA Damage Induced by ROS. , Genetic Modifiers Influence the Functional Role of Checkpoint Genes in Stem Cells -- FoxO-Dependent Restriction of Cell Cycle Maintains Neuronal Stem Cells in Mouse Brain -- Conclusion -- References -- Subject Index.

Note: Cover -- Front Matter -- Contents -- Preface -- Adult Stem Cells in Aging, Diseases and Cancer -- The Else Kröner-Fresenius-Stiftung -- Introduction -- Speakers at the Symposium -- Steven Artandi, MD, PhD -- Axel Behrens, PhD -- Cédric Blanpain, MD, PhD -- Andrew Brack, PhD -- Anne Brunet, PhD -- Andrei V. Budanov, PhD -- Tao Cheng, MD -- Gerald de Haan, PhD -- Jan van Deursen, PhD -- Connie J. Eaves, PhD -- Bruce Edgar, PhD -- Hartmut Geiger, PhD -- Margaret A. Goodell, PhD -- Heinrich Jasper, PhD -- D. Leanne Jones, PhD -- Jan Karlseder, PhD -- Michael Milyavsky, PhD -- Huck-Hui Ng, PhD -- Andre Nussenzweig, PhD -- Emmanuelle Passegué, PhD -- Pier Giuseppe Pelicci, MD, PhD -- Thomas A. Rando, MD, PhD -- Hans-Reimer Rodewald, PhD -- Derrick Rossi, PhD -- Michael Rudnicki, PhD -- Karl Lenhard Rudolph, MD -- Björn Schumacher, PhD -- Manuel Serrano, PhD -- Toshio Suda, MD -- Elly M. Tanaka, PhD -- Andreas Trumpp, PhD -- Maarten van Lohuizen, PhD -- Amy J. Wagers, PhD -- Stem Cells in Adult Intestine -- Abstract -- Intestine -- Intestinal Stem Cells -- Stem Cells in Drosophila Midgut -- Notch and Delta -- Other Signaling Pathways -- Outlook -- References -- Molecular Mechanisms of Muscle Stem Cell Aging -- Abstract -- Morphological and Molecular Properties of Muscle Stem Cells -- Molecular Mechanism of Satellite Cell Aging -- Epigenetic Regulation of Myogenic Stem Cells during Aging -- Molecular Mechanism of Cardiac Muscle Aging and Disease -- Conclusions and Perspectives -- References -- Mechanism of Functional Alterations in Hematopoietic Stem Cell Aging -- Abstract -- Characteristics of Hematopoietic Stem Cells -- Functional Alteration of Hematopoietic Stem Cells during Aging -- Molecular Mechanisms in Hematopoietic Stem Cell Aging -- Epigenetic Regulation of Stem Cell Function -- DNA Damage Signaling in the Regulation of Hematopoietic Stem Cells. , Genes Controlling Quiescence and Self-Renewal of Hematopoietic Stem Cells -- Conclusions -- References -- The Microenvironment, Aging and Disease -- Abstract -- The Influence of the Niche and the Environment on Stem Cells in Disease and Aging -- Modeling Myelodysplastic Syndromes: The Role of the Niche -- Stem Cell Proliferation and Tissue Homeostasis in the Aging Drosophila Intestine -- Polarity and Wnt5 a Signaling Are Central to Stem Cell Aging -- References -- Sestrins in Aging and Metabolism -- Abstract -- Drosophila Sestrin as a Feedback Inhibitor of TOR Protects Drosophila from Accumulation of Aging-Related Pathologies -- Sesn2 and Sesn3 Maintain Metabolic Homeostasis in Mammalians -- References -- Telomeres and Stem Cell Aging -- Abstract -- Telomerase, Adult Stem Cells and Cancer -- Studying Telomerase in vivo -- Stalled Replication Induces the ALT Pathway -- Breast Stem Cells with High Telomerase Activity but Short Telomeres -- Pot1a Expression Enhances Colony Formation Ability of Hematopoietic Stem Cells -- Conclusions -- References -- DNA Damage and Checkpoint Responses in Adult Stem Cells -- Abstract -- DNA Damage Accumulation during Hematopoietic Stem Cell Aging -- p53-/p21-Dependent DNA Damage Response in Stem Cells -- DNA Damage Response in Human Hematopoietic Stem Cells -- Stem and Progenitor Cell Senescence in Aging -- Outlook -- References -- Thomas Hell Plays 'Vertigo' by György Ligeti -- Thomas Hell -- Author Index -- Subject Index -- Cover.