Note: Front Cover -- Glucose-6-Phosphate Dehydrogenase -- Copyright Page -- Table of Contents -- PREFACE -- Pau l E. Carson-In Memoriam -- PART I: G6PD DEFICIENCY AND HEMOLYTIC ANEMIA -- CHAPTER 1. DRUG-INDUCED HEMOLYTIC ANEMIA AND NON-SPHEROCYTIC HEMOLYTIC ANEMIA -- I. DRUG INDUCED HEMOLYSIS -- II. MECHANISM OF HEMOLYSIS -- III. HEREDITARY NONSPHEROCYTIC HEMOLYTIC ANEMIA -- REFERENCES -- CHAPTER 2. PHARMACOGENETIC INTERACTION OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY WITH ACETYLATION AND HYDROXYLATION -- THE MYSTERY -- OUR STUDY OF METABOLIC INTERACTIONS -- A REMAINING MYSTERY -- SUMMARY -- REFERENCES -- CHAPTER 3. FAVISM: EPIDEMIOLOGICAL AND CLINICAL ASPECTS -- 1. INTRODUCTION -- 2. EPIDEMIOLOGICAL DATA -- 3. CLINICAL ASPECTS -- 4. LABORATORY DATA -- COMMENTS -- REFERENCES -- CHAPTER 4. ETIOLOGICAL ASPECTS OF FAVISM -- I. THE FAVIC CRISIS -- II. GENETIC ASPECTS -- III. HAZARDOUS CONSTITUENTS OF VICIA FABA -- IV. RED CELL GLUTATHIONE IN FAVISM -- V. METABOLIC MODIFICATIONS IN FAVISM -- VI. CALCIUM HOMEOSTASIS IN FAVISM -- VII. RHEOLOGY AND MEMBRANE CROSS BONDING IN FAVISM -- VIII. ERYTHROPHAGOCYTOSIS IN FAVISM -- IX· CONCLUDING REMARKS -- ACKNOWLEDGEMENTS -- REFERENCES -- CHAPTER 5. DIVICINE AND G6PD-DEFICIENT ERYTHROCYTES: AN INTEGRATED MODEL OF CYTOTOXICITY IN FAVISM -- I. INTRODUCTION -- II. AUTOOXIDATION OF DIVICINE -- III. INTERACTIONS BETWEEN DIVICINE AND THE HEMOGLOBIN-METHEMOGLOBIN SYSTEM -- IV. INTRACELLULAR DAMAGING EFFECTS OF DIVICINE ON G6PD-DEFICIENT ERYTHROCYTES -- V. FUTURE PERSPECTIVES -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 6. G6PD-RELATED NEONATAL JAUNDICE -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 7. REGULATION OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE IN NORMAL AND VARIANT RED BLOOD CELLS -- I. THE HEXOSE MONOPHOSPHATE 5HUNT AND GLUCOSE-6-PHOSPHATE DEHYDROGENASE -- II. A DISCREPANCY BETWEEN OBSERVED AND EXPECTED ACTIVITIES. , III. EXTENSIVE BINDING OF INTRACELLULAR NADP -- IV. UNANSWERED QUESTIONS -- REFERENCES -- CHAPTER 8. INTRAERYTHROCYTIC STABILITY OF NORMAL AND MUTANT G6PD -- I. INTRODUCTION -- II. MATERIALS AND METHODS -- III. RESULTS -- IV. DISCUSSION -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 9. OXIDANT-INDUCED MEMBRANE DAMAGE IN G-6-PD DEFICIENT RED BLOOD CELLS -- I. INTRODUCTION -- II. STUDIES OF THE MECHANISM OF CHRONIC HEMOLYSIS -- III. PATHOPHYSIOLOGIC IMPLICATIONS -- IV. THERAPEUTIC IMPLICATIONS -- REFERENCES -- PART II: G6PD VARIATION -- CHAPTER 10. ORIGIN OF G6PD POLYMORPHISM: MALARIA AND G6PD DEFICIENCY -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 11. G6PD VARIANTS IN SOUTHERN ASIAN POPULATIONS -- INCIDENCE OF G6PD DEFICIENCY AND DESCRIPTION OF VARIANTS BY POPULATION GROUPS -- COMMON G6PD VARIANTS IN SOUTHERN ASIAN POPULATIONS -- CLINICAL PICTURES OF THE VARIANTS -- CONCLUSION -- REFERENCE -- CHAPTER 12. GLUC0SE-6-PH0SPHATE DEHYDROGENASE DEFICIENCY AND MALARIA IN CENTRAL THAILAND -- CHAPTER 13. G6PD VARIATION IN INDIA -- I. INTRODUCTION -- II. MATERIAL AND METHODS -- III. RESULTS -- IV. DISCUSSION -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 14. GLUCOSE-6-PHOSPHATE DEHYDROGENASE VARIANTS IN JAPAN -- ABSTRACT -- I. INTRODUCTION -- II. MATERIALS AND METHODS -- III. RESULTS -- IV. DISCUSSION -- REFERENCES -- CHAPTER 15. DISCUSSION -- REFERENCES -- CHAPTER 16. GLUCOSE-6-PHOSPHATE DEHYDROGENASE FROM LEUCONOSTOC MESENTEROIDES -- I. INTRODUCTION -- II. MOLECULAR PROPERTIES -- III. KINETIC STUDIES -- IV. BINDING STUDIES -- V. REGULATION -- VI. CONCLUSIONS -- REFERENCES -- CHAPTER 17. G6PD OF DROSOPHILIA MELANOGASTER -- I. INTRODUCTION -- II. DROSOPHILA G6PD -- REFERENCES -- CHAPTER 18. GLUCOSE-6-PHOSPHATE DEHYDROGENASE AND HEXOSE-6-PHOSPHATE DEHYDROGENASE: AN EVOLUTIONARY ASPECT -- ABSTRACT -- I. INTRODUCTION -- II. DIVERGENCE OF H6PD FROM G6PD. , III. FUNCTIONAL DIFFERENTIATION OF G6PD AND H6PD -- REFERENCES -- CHAPTER 19. SIGNALS REGULATING GLUC0SE-6-P DEHYDROGENASE LEVELS IN RAT LIVER -- REFERENCES -- CHAPTER 20. HEPATIC GLUCOSE-6-PHOSPHATE DEHYDROGENASE: NUTRITIONAL AND HORMONAL REGULATION OF mRNA LEVELS -- I. INTRODUCTION -- II. EXPERIMENTAL PROCEDURES -- III. RESULTS -- IV. CONCLUSIONS -- REFERENCES -- CHAPTER 21. TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL REGULATION OF UTERINE GLUCOSE-6-PHOSPHATE DEHYDROGENASE BY ESTRADIOL -- I. INTRODUCTION -- II. REGULATORY SEQUENCES INVOLVING G6PD AND HMP PATHWAY ACTIVITIES IN THE ESTROGEN-INDUCED UTERUS -- III. MOLECULAR EVENTS THROUGH WHICH THE AMOUNT OF UTERINE G6PD APOPROTEIN IS REGULATED BY ESTRADIOL -- IV. MECHANISMS BY WHICH UTERINE G6PD SYNTHESIS AND MODIFICATIONS MAY BE REGULATED BY ESTRADIOL -- V. CONCLUSIONS -- REFERENCES -- PART III: EXPRESSION OF Gd LOCUS -- CHAPTER 22. G6PD AS A TOOL AND A TARGET FOR STUDIES ON X-CHROMOSOME LINKAGE -- REFERENCES -- CHAPTER 23. X-INACTIVATION IN FEMALES HETEROZYGOUS FOR G-6-PD VARIANTS -- I. THE ORIGIN OF THE CONCEPT OF X-INACTIVATION -- II. EXPRESSION OF G-6-PD DEFICIENCY IN THE RED CELLS OF HETEROZYGOUS FEMALES -- III. DIAGNOSIS OF THE HETEROZYGOUS DEFICIENT STATE -- IV. TISSUE DISTRIBUTION OF GENE PRODUCTS IN HETEROZYGOTES -- V. CLINICAL MANIFESTATIONS IN HETEROZYGOTES -- CHAPTER 24. MECHANISM OF MAMMALIAN X-CHROMOSOME INACTIVATION -- I. INTRODUCTION -- II. DNA METHYLATION AND CONTROL OF GENE ACTIVITY -- III. DNA METHYLATION AND MAINTENANCE OF X-CHROMOSOME INACTIVATION -- IV. MOLECULAR STUDIES ON THE MECHANISM OF X-INACTIVATION -- ACKNOWLEDGEMENTS -- REFERENCES -- CHAPTER 25. INSIGHTS INTO G6PD REGULATION FROM STUDIES OF X DOSAGE COMPENSATION -- ACKNOWLEDGEMENT -- REFERENCES -- CHAPTER 26. POLYCLONAL TUMORS -- INTRODUCTION -- POLYCLONAL GROWTH AS AN INITIAL STAGE IN HEREDITARY TUMORS. , POLYCLONAL MALIGNANT TUMORS -- LEIOMYOMAS OF THE UTERUS -- SUMMARY -- ACKNOWLEDGMENT -- REFERENCE -- CHAPTER 27. G-6-PD AS A MARKER FOR TUMORS -- REFERENCES -- CHAPTER 28. GLUCOSE-6-PHOSPHATE DEHYDROGENASE AND MOSAIC ANALYSIS OF HUMAN ATHEROSCLEROTIC LESIONS -- I. INTRODUCTION -- II. DISCUSSION -- ACKNOWLEDGMENTS -- REFERENCES -- PART IV: MOLECULAR BIOLOGY OF HUMAN G6PD -- CHAPTER 29. STRUCTURE OF HUMAN GLUCOSE-6-PHOSPHATE DEHYDROGENASE -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 30. IDENTIFICATION OF A REACTIVE LYSINE RESIDUE IN HUMAN ERYTHROCYTE GLUCOSE-6-PHOSPHATE DEHYDROGENASE -- I. INTRODUCTION -- II. RESULTS -- III. DISCUSSION -- REFERENCES -- CHAPTER 31. KINETICS AND MOLECULAR ABNORMALITIES OF HUMAN G6PD VARIANTS -- INTRODUCTION -- CONCLUSION -- REFERENCES -- CHAPTER 32. ANALYSIS OF THE PRIMARY STRUCTURE OF HUMAN G6PD DEDUCED FROM THE cDNA SEQUENCE -- Conclusion -- REFERENCES -- CHAPTER 33. MOLECULAR CLONING OF cDNA FOR G6PD -- ACKNOWLEDGMENTS -- REFERENCES -- INDEX.