ISSN:
1432-0878
Keywords:
Vitamin A-deficiency
;
Paneth cells
;
Crystalloid lysozyme
;
Tubular structures
;
Intestinal local immunity
;
Electron microscopy
;
Rat (Sprague-Dawley)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The effect of vitamin A-deficiency on jejunal Paneth cells in rats was investigated. Crystalloid particles were observed in secretion granules of Paneth cells from 6 out of 8 rats with vitamin A-deficiency. The particles were similar to those found in Paneth cells under other experimental conditions. Using an immuno-electron-microscopic technique we demonstrated a clear lysozyme immunoreactivity of these particles. In 2 vitamin A-deficient rats tubular structures have been detected in addition to the crystalloid particles. Crystalloid particles or tubular structures were not detectable in a control group of 8 vitamin A-supplemented rats. The morphological alterations of Paneth cells may be correlated to an impaired local immunity of the intestine during vitamin A-deficiency.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00297244
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