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  • Keywords Interstitial cystitis  (3)
  • Domestic duck  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Intravesikale Therapie bei interstitieller Zystitis (2000)
    Springer
    Der Urologe 39 (2000), S. 542-544 
    Details
    ISSN: 1433-0563
    Keywords: Schlüsselwörter Interstitielle Zystitis ; Instillation ; Pentosanpolysulfat ; Dimethylsulfoxid ; Heparin ; Keywords Interstitial cystitis ; Instillation ; Pentosanpolysulfate ; Dimethylsulfoxide ; Heparin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Intravesically applied medications have the benefit of establishing high concentrations of a therapeutic agent at the intended target tissue along with a low risk for systemic side effects. Pentosanpolysulfate is frequently applied for this purpose and was shown to significantly reduce nycturia while frequency during the day remained unaffected in a controlled study. Heparin reduced nycturia in an open prospective protocol as well. For heparin the maximal onset of a therapeutic effect is often observed as late as 4–6 months after initiation of treatment. Heparin as well as pentosanpolysulfate cause practically no side effects. Dimethylsulfoxide (DMSO), when instilled intravesically, decreases symptoms up to 50–70% for an effective period of 1–2 months. An irritating but harmless side effect of DMSO is the development of a striking garlic-like odor. BCG improved symptoms in 10 of 15 patients after 8 months and in 8 of 15 patients after 24 months. No patient with an initial bladder capacity below 175 cc benefited from BCG instillations. Discomfort in the bladder region was noted as a frequent side effect. Instillations of clorpactin WCS 90 are painful and can thus only be applied under anesthesia. Success rates range between 50–70% and last for 6–12 months.
    Notes: Zusammenfassung Die intravesikale Instillationstherapie hat den Vorteil einer hohen Wirkkonzentration in der Blase bei geringen systemischen Nebenwirkungen. Pentosanpolysulfat wird relativ häufig zur Blaseninstillation eingesetzt und senkt signifikant die Nykturiefrequenz, während die Miktionsfrequnz tagsüber in einer kontrollierten Studie unverändert blieb. Auch Heparin senkte die Nykturiefrequenz in einer offenen prospektiven Studie. Der maximale Wirkungseintritt wird bei Heparin oft erst nach 4–6 Monaten bemerkt. Sowohl Heparin als auch Pentosanpolysulfat sind praktisch nebenwirkungsfrei. Dimethylsulfoxid (DMSO) in die Blase instilliert, führt zu einer Symptomverbesserung zwischen 50 und 70% bei einer Erfolgsdauer zwischen 1 und 2 Monaten. Als Nebenwirkung wird ein unverkennbarer Knoblauchgeruch vermerkt. BCG besserte die Symptomatik bei 10 von 15 Patienten nach 8 Monaten und 8 von 15 Patienten nach 24 Monaten. Bei einer Blasenausgangskapazität 〈175 ml half BCG keiner Patientin. Als Nebenwirkung trat häufig ein Brennen in der Blase auf. Die Instillation von Clopactin ist wegen der damit verbundenen Blasenschmerzen nur in Narkose möglich und wird heute kaum noch durchgeführt. Die Erfolgsraten liegen zwischen 50 und 70% für 6–12 Monate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001200050406
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  • 2
    Electronic Resource
    Electronic Resource
    Endourologische Operationstechniken bei interstitieller Zystitis (2000)
    Springer
    Der Urologe 39 (2000), S. 545-546 
    Details
    ISSN: 1433-0563
    Keywords: Schlüsselwörter Interstitielle Zystitis ; Transurethrale Resektion ; Laser ; Endourologie ; Keywords Interstitial cystitis ; Transurethral resection ; Lasers ; Endourology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Endourological surgical procedures (transurethral resection and fulguration, Nd-YAG-laser application) for the treatment of interstitial cystitis (IC) have been evaluated only in a few studies. Theoretically, they could be the next step in a therapeutic concept after conservative measures have failed and before open surgery is performed as an ultima ratio. However, our review of the literature suggests that to date there is no scientific evidence to support endourological techniques in the treatment of IC.
    Notes: Zusammenfassung Endourologische Operationstechniken (transurethrale Resektion und Koagulation, Nd-YAG-Laser) zur Behandlung der interstitiellen Zystitis (IC) wurden nur in wenigen Studien wissenschaftlich untersucht. Nach Ausschöpfen konservativer Behandlungsstrategien stellen sie theoretisch den nächsten Schritt im Therapiekonzept dar, bevor offen chirurgische Behandlungsansätze als Ultima ratio zum Einsatz kommen. Diese Übersicht zeigt, dass nach Anwendung strenger Kriterien aus dem Bereich der evidenzbasierten Medizin, wissenschaftliche Grundlagen für die Empfehlung endourologischer Techniken zur Behandlung der IC noch weitgehend fehlen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001200050407
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  • 3
    Electronic Resource
    Electronic Resource
    Stellenwert von Hydrodistension und Blasentraining (2000)
    Springer
    Der Urologe 39 (2000), S. 539-541 
    Details
    ISSN: 1433-0563
    Keywords: Schlüsselwörter Interstitielle Zystitis ; Blasendehnung ; Hydrodistension ; Blasentraining ; Keywords Interstitial cystitis ; Bladder distension ; Bladder training ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Although hydrodistension of the bladder is generally considered standard therapy for interstitial cystitis, scientific data are largely lacking. With the mechanism of action unknown, prospective studies non-existent and the therapeutic effect at best very short-lived, hydrodistension cannot be regarded as a therapeutic standard concept with scientifically validated efficacy. The value of behavioral therapy and bladder training is equally unclear; success can only be anticipated in the very rare subset of patients without pain.
    Notes: Zusammenfassung Obwohl die Hydrodistension der Harnblase ein häufig angewendetes Konzept in der Behandlung der intestitiellen Zystitis (IC) darstellt, ist die wissenschaftliche Datenlage zur therapeutischen Blasendehnung spärlich. Bei ungeklärtem Wirkungsmechanismus, fehlenden prospektiven und kontrollierten Studien und bestenfalls kurzfristiger Effektivität kann die Hydrodistension nicht als therapeutisches Standardkonzept mit wissenschaftlich nachgewiesenem Behandlungserfolg angesehen werden und besitzt eher den Stellenwert eines Heilversuchs. Die Wertigkeit von Blasentraining oder ähnlichen Miktonsverhaltensmodifikationen bei der IC bleibt ebenfalls unklar, ein gewisser Effekt kann allenfalls für die vergleichsweise kleine Untergruppe von IC-Patienten ohne Schmerzkomponente erwartet werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001200050405
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  • 4
    Electronic Resource
    Electronic Resource
    Vasotocin acts as a dipsogen in ducks at concentrations stimulating subfornical organ neurons in vitro (1996)
    Springer
    Journal of comparative physiology 165 (1996), S. 615-621 
    Details
    ISSN: 1432-136X
    Keywords: Subfornical organ ; Water intake ; Arginine vasotocin ; Angiotensin II ; Domestic duck
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effects of systemic infusions of the avian antidiuretic hormone arginine vasotocin on water intake of domestic ducks were investigated under steady conditions of water balance in which angiotensin II was effective as a dipsogen. The study proceeded from the consistent stimulatory effect of arginine vasotocin on angiotensin II-responsive neurons found in the subfornical organ of ducks, suggesting brain-intrinsic vasotocinergic control of these neurons which are also accessible to circulating agents because of the lacking blood-brain barrier. Levels of circulating arginine vasotocin of about 2700 pg·ml-1 which were close to the threshold for activation of subfornical organ neurons in vitro, induced weak but significant drinking responses. Even at this high arginine vasotocin level circulatory effects were absent, thereby excluding their interference with water intake. Arginine vasotocin plasma levels of about 60 pg·ml-1 significantly attenuated the dipsogenic action of angiotensin. While drinking in response to high pharmacological levels of arginine vasotocin is assumed to mimic a stimulatory innervation of angiotensin-responsive subfornical organ neurons by brain-intrinsic vasotocinergic axons, attenuation of angiotensin-induced drinking by high physiological arginine vasotocin levels cannot be explained by its action on central neurons, but may be secondary to body fluid retention caused by the antidiuretic action of arginine vasotocin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00301129
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of angiotensin II and its blockers Sar1-lle8-angiotensin II and DuP 753 on drinking in ducks in relation to properties of subfornical organ neurons (1996)
    Springer
    Journal of comparative physiology 165 (1996), S. 607-614 
    Details
    ISSN: 1432-136X
    Keywords: Subfornical organ ; Water intake ; Angiotensin II ; Losartan ; Sar1-Ile8-angiotensin II ; Domestic duck
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Properties of systemically applied angiotensin II in stimulating water intake of normally hydrated ducks were studied and the results compared with properties of angiotensin II-responsive neurons of the subfornical organ which are considered as targets for circulating angiotensin, II acting as a dipsogen. Following intravenous infusion of hypertonic saline (2000 mosmol·kg-1 at 0.3 ml·min-1 for 1 h), intravenous infusion of 0.3 ml·min-1 isotonic saline with angiotensin II (200 ng·min-1), starting 1 h later, stimulated drinking in each case at an angiotensin II plasma level of about 1400 pg·ml-1. Without hypertonic priming, the same angiotensin II infusion did not stimulate drinking in each experiment; however, if effective, repeated infusions of ANGII induced stable dipsogenic responses. Angiotensin II infusions did not alter plasma levels of antidiuretic hormone. Sar1-Ile8-angiotensin II, a non-selective angiotensin II antagonist, acted weakly as a partial agonist when injused at a dose 200-fold higher than angiotensin II and effectively blocked the dipsogenic action of angiotensin II; this corresponds to the inhibition of angiotensin II-induced excitation by Sar1-Ile8-angiotensin II observed in duck subfornical organ neurons. DuP 753 (losartan), an angiotensin II antagonist specifically blocking AT1 receptors in mammals, had equivocal effects on angiotensin II-induced drinking in ducks at rates 50- and 200-fold higher than angiotensin II, which corresponds to the weak inhibitory action of this compound on angiotensin II-induced neuronal excitation in the duck SFO. Blood pressure was only marginally elevated by the applied angiotensin II dose and Sar1-Ile8-angiotensin II had no effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00301128
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    Paper (German National Licenses)
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