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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of mathematical biology 28 (1990), S. 383-410 
    ISSN: 1432-1416
    Keywords: Discrete dynamical systems ; Strange attractor ; Lotka-Volterra cooperation ; Permanence ; Hopf bifurcation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract We study the discrete model for cooperation as expressed through the dynamics of the family of noninvertible planar maps (x, y) → (x exp(r(1 − x) + sy), y exp(r(1 − y) + sx)), with parameters r, s 〉 0. We prove that the map is proper in the open positive quadrant and describe its various stretching and folding actions. We determine conditions for a Hopf bifurcation — probably one of a cascade of double, quadruple, ... limit cycles, as a curve is followed in parameter space. For r 〉 s an approximating version of the map is dissipative and permanent in the positive quadrant. We include the results of an extensive computer simulation, including a bifurcation diagram (y vs. r, with s fixed) through which is cut a number of x−y phase-plane plots; (an r−y curve penetrates each plot like a thread through cards). These indicate a complex dynamical evolution for cooperation, from stable cycle to strange attractor. A general conclusion is that the benefit of cooperation can be relatively high average values at the cost of oscillations of high amplitude.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2013-09-12
    Description: Objective— Interleukin-19 (IL-19) is a putative Th2, anti-inflammatory interleukin. Its expression and potential role in atherogenesis are unknown. IL-19 is not detected in normal artery and is expressed to a greater degree in plaque from symptomatic versus asymptomatic patients, suggesting a compensatory counter-regulatory function. We tested whether IL-19 could reduce atherosclerosis in susceptible mice and identified plausible mechanisms. Approach and Results— LDLR –/– mice fed an atherogenic diet and injected with either 1.0 or 10.0 ng/g per day recombinant mouse IL-19 had significantly less plaque area in the aortic arch compared with controls ( P 〈0.0001). Weight gain, cholesterol, and triglyceride levels were not significantly different. Gene expression in splenocytes from IL-19–treated mice demonstrated immune cell Th2 polarization, with decreased expression of T-bet, interferon-, interleukin-1β, and interleukin-12β and increased expression of GATA3 and FoxP3 mRNA. A greater percentage of lymphocytes were Th2 polarized in IL-19–treated mice. Cellular characterization of plaque by immunohistochemistry demonstrated that IL-19–treated mice have significantly less macrophage infiltrate compared with controls ( P 〈0.001). Intravital microscopy revealed significantly less leukocyte adhesion in wild-type mice injected with IL-19 and fed an atherogenic diet compared with controls. Treatment of cultured endothelial cells, vascular smooth muscle cells, and bone marrow–derived macrophages with IL-19 resulted in a significant decrease in chemokine mRNA and mRNA stability protein human antigen R. Conclusions— These data suggest that IL-19 is a potent inhibitor of experimental atherosclerosis, with diverse mechanisms including immune cell polarization, decrease in macrophage adhesion, and decrease in gene expression. This may identify IL-19 as a novel therapeutic to limit vascular inflammation.
    Keywords: Gene expression, Growth factors/cytokines
    Print ISSN: 1079-5642
    Electronic ISSN: 1524-4636
    Topics: Medicine
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