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  • Articles  (2)
  • Dermatologische Assoziationen  (1)
  • Peptidyl transferase centre  (1)
  • 1
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Hepatitis-C-Virus ; Dermatologische Assoziationen ; Key words Hepatitis C-virus ; Dermatologic manifestations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Acute infection with hepatitis C virus (HCV) is often clinically inapparent, but may affect several organ systems in its chronic course. In dermatology, common diseases such as lichen planus, cryoglobulinemic vasculitis and porphyria cutanea tarda have been described in association with HCV infection. A number of other dermatologic disorders, e.g., psoriasis, chronic urticaria, chronic pruritus, pseudo-kaposi sarcoma, necrolytic migratory erythema and Behçet disease, have been associated in case reports with HCV-induced liver disease. In this study we summarize the recent literature reports, present three patients observed by our group and update the topic.
    Notes: Zusammenfassung Die Infektion mit dem Hepatitis-C-Virus (HCV) verläuft im akuten Stadium meist asymptomatisch. Häufig entwickelt sich jedoch in der Folge eine klinisch stumme Hepatitis, die anschließend in eine Leberzirrhose münden kann. In den letzten Jahren wurden zahlreiche Erkrankungen verschiedener Organsysteme (z.B. Endokrinium, Knochenmark, Niere) in Assoziation mit der HCV-Infektion beschrieben, darunter auch diverse Dermatosen. Bei den HCV-assoziierten Dermatosen handelt es sich v.a. um Lichen ruber, kryoglobulinassoziierte Vaskulitiden oder Porphyria cutanea tarda. Auch für das Vorkommen anderer häufiger Dermatosen wie Psoriasis, chronisch-rezidivierende Urtikaria oder kasuistisch für chronischen Pruritus, Pseudokaposi, nekrolytische Erytheme, Morbus Behçet u.v.a. wurde die Assoziation mit einer Hepatitis-C-Infektion berichtet. In der vorliegenden Übersicht werden die derzeitigen Kenntnisse zusammengefaßt, drei Fälle aus dem eigenen Krankheitsgut vorgestellt und entsprechende Schlußfolgerungen gezogen.
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  • 2
    ISSN: 1617-4623
    Keywords: Ribosomal topography ; Ribosomal protein L27 ; Immuno-electron microscopy ; Peptidyl transferase centre
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Protein L27 has been localized on the ribosomal surface by immuno-electron microscopy by using antibodies specific for Escherichia coli L27, and by reconstituting 50 S subunits from an E. coli mutant, which lacks protein L27, with the homologous protein from Bacillus subtilis and using antibodies specific for the B. subtilis protein. With both approaches, protein L27 has been located at the base of the central protuberance at the interface side of the 50 S particle and thus in proximity to the peptidyl transferase centre. The immuno-electron microscopic data also suggest that the interface region of the 50 S particle is not as flat as most of the proposed three-dimensional models suggest, but instead there is a significant depression.
    Type of Medium: Electronic Resource
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