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  • 1
    Electronic Resource
    Electronic Resource
    Elevated plasma endothelin levels in systemic sclerosis (1995)
    Springer
    Archives of dermatological research 287 (1995), S. 439-442 
    Details
    ISSN: 1432-069X
    Keywords: Systemic sclerosis ; Endothelin ; Thrombomodulin ; Raynaud's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Endothelin is a novel potent vasoconstrictor peptide produced mainly by endothelial cells. Thrombomodulin is a high-affinity thrombin receptor on vascular endothelial cells that plays an important role as a natural anticoagulant. In this study, we measured plasma levels of endothelin and thrombomodulin in patients with systemic sclerosis or Raynaud's disease. Plasma levels of endothelin and the ratio of thrombomodulin to creatinine were significantly increased in patients with systemic sclerosis compared with normal controls, and there was a positive correlation between these two indicators (r=0.615, P=0.004). Moreover, plasma levels of endothelin were significantly higher in patients with diffuse systemic sclerosis than in patients with limited systemic sclerosis. In contrast, plasma levels of endothelin in patients with Raynaud's disease were not significantly increased. These results suggest that increased plasma levels of endothelin and thrombomodulin may reflect microvascular damage in systemic sclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00373425
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Glycosaminoglycans in congenital pseudarthrosis (1977)
    Springer
    Calcified tissue international 23 (1977), S. 271-275 
    Details
    ISSN: 1432-0827
    Keywords: Pseudarthrosis ; Glycosaminoglycans ; Dermatan sulfate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Light and electron microscopic studies on cells and matrices of congenital pseudarthrosis of the femur of a 5.5-year-old male revealed three areas with different morphological features; a fibrous area, a cartilaginous area and an osseous area. Glycosaminoglycans were isolated from each of the three areas and characterized by the degradation with chondroitinases. Although chondroitin sulfate was the major component in all regions, a significant amount of dermatan sulfate occurred in the fibrous area. A small amount of hyaluronic acid was found in both fibrous and osseous areas. These results suggest that the peculiar composition of glycosaminoglycans in the affected part may account for some clinical aspects of the disease which resists treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02012796
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    Paper (German National Licenses)
    Fulltext
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