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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Engineering with computers 14 (1998), S. 275-286 
    ISSN: 1435-5663
    Keywords: Computer-aided design of buildings ; Database management system ; Hierarchical index ; Object-oriented model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Notes: Abstract An effective database and database management system is the key to the success of an integrated approach to software engineering applications in general, and Computer-Aided Design (CAD) for structural applications in particular. Due to the inherent nature of CAD data such as dynamic modeling, a wide range of data types, large data volume, etc., the traditional database models, such as hierarchical, network and relational models, are unable to handle the aforementioned applications satisfactorily. An object-oriented data modeling is known to be the most effective approach. However, many of the commercial object-oriented databases are designed for information management, and they are inadequate for CAD application due to the different features of the object-hierarchy and varying data management objectives during the design cycles. This paper presents a hierarchical index-based object-oriented database management model for CAD applications. To deal with the object hierarchy encountered in CAD for the design of tall buildings, the proposed database consists of several salient features: a hierarchical object model, its related storage structure, a data dictionary, a class factory and an index system. The proposed database management model has been implemented into an integrated CAD system for design application of tall buildings.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2012-08-03
    Description: Dysregulation of cyclin-dependent kinase 4 (CDK4) and CDK6 by gain of function or loss of inhibition is common in human cancer, including multiple myeloma, but success in targeting CDK with broad-spectrum inhibitors has been modest. By selective and reversible inhibition of CDK4/CDK6, we have developed a strategy to both inhibit proliferation and enhance cytotoxic killing of cancer cells. We show that induction of prolonged early-G 1 arrest ( pG1 ) by CDK4/CDK6 inhibition halts gene expression in early-G 1 and prevents expression of genes programmed for other cell-cycle phases. Removal of the early-G 1 block leads to S-phase synchronization ( pG1-S ) but fails to completely restore scheduled gene expression. Consequently, the IRF4 protein required to protect myeloma cells from apoptosis is markedly reduced in pG1 and further in pG1-S in response to cytotoxic agents, such as the proteasome inhibitor bortezomib. The coordinated loss of IRF4 and gain of Bim sensitize myeloma tumor cells to bortezomib-induced apoptosis in pG1 in the absence of Noxa and more profoundly in pG1-S in cooperation with Noxa in vitro. Induction of pG1 and pG1-S by reversible CDK4/CDK6 inhibition further augments tumor-specific bortezomib killing in myeloma xenografts. Reversible inhibition of CDK4/CDK6 in sequential combination therapy thus represents a novel mechanism-based cancer therapy.
    Keywords: Lymphoid Neoplasia
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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