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  • 1
    Keywords: Artificial intelligence. ; Artificial intelligence-Congresses. ; Data mining. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (523 pages)
    Edition: 1st ed.
    ISBN: 9783031154713
    Series Statement: Lecture Notes in Computer Science Series ; v.13469
    DDC: 006.3
    Language: English
    Note: Intro -- Preface -- Organization -- Contents -- Bioinformatics -- A Comparison of Machine Learning Techniques for the Detection of Type-4 PhotoParoxysmal Responses in Electroencephalographic Signals -- 1 Introduction -- 2 Preliminaries and Related Work -- 3 Type-4 PPR Detection Using ML -- 3.1 Dimensional Reduction -- 3.2 Clustering and Classification -- 4 Materials and Methods -- 4.1 Data Set Description -- 4.2 Experimentation Design -- 5 Results and Discussion -- 6 Conclusions and Future Work -- References -- Smartwatch Sleep-Tracking Services Precision Evaluation Using Supervised Domain Adaptation -- 1 Introduction -- 2 The Proposal -- 2.1 Step1: RAW Signals Preprocessing -- 2.2 Step2: Features Computing -- 2.3 Steps 3 and 4: Models Training and Domain Adaptation -- 3 Numerical Results -- 3.1 Materials and Methods -- 3.2 Experimentation Set up -- 3.3 Numerical Results -- 4 Conclusions and Future Work -- References -- Tracking and Classification of Features in the Bio-Inspired Layered Networks -- 1 Introduction -- 2 Bio-Inspired Neural Networks -- 2.1 Background of Asymmetric Neural Networks Based on the Bio-Inspired Network -- 2.2 Model of Asymmetric Networks -- 2.3 Tracking in the Asymmetric Networks -- 2.4 Orthogonality in the Asymmetric Layered Networks -- 3 Sparse Coding for Classification in the Extended Asymmetric Networks -- 3.1 Independence and Sparse Coding on the Orthogonal Subnetworks -- 3.2 Generation of Independent Basis Set via Sparse Coding Realization -- 4 Application to Data Classification via Sparse Coding Realization in the Asymmetric Networks -- 5 Conclusion -- References -- Frailty Related Survival Risks at Short and Middle Term of Older Adults Admitted to Hospital -- 1 Introduction -- 2 Materials and Methods -- 2.1 Study Design and Subjects -- 2.2 Statistical Methods -- 3 Results -- 4 Discussion. , 5 Conclusions and Future Work -- References -- On the Analysis of a Real Dataset of COVID-19 Patients in Alava -- 1 Introduction -- 2 Related Work -- 3 Methods -- 3.1 Study Design -- 3.2 Ethical Approval and Patient Consent -- 3.3 Data Collection and Description -- 3.4 Attribute Analysis -- 3.5 Principal Component Analysis -- 3.6 Logistic Regression Feature Importance -- 4 Discussion -- 5 Conclusion -- References -- Indoor Access Control System Through Symptomatic Examination Using IoT Technology, Fog Computing and Cloud Computing -- 1 Introduction -- 2 Related Works -- 3 Operation of the Control System -- 3.1 Facial Recognition Module -- 3.2 Steps of the Detection System -- 3.3 Medical Sensors -- 3.4 Fog Computing -- 3.5 Statistics Management and User Registration Module -- 3.6 Accessibility Improvements -- 4 Conclusions and Future Work Lines -- References -- Data Mining and Decision Support Systems -- Measuring the Quality Information of Sources of Cybersecurity by Multi-Criteria Decision Making Techniques -- 1 Introduction -- 2 Background -- 2.1 Related Work -- 2.2 DQ Model -- 3 Ranking of Sources by MCDM -- 3.1 Weighted Sum Model (WSM) -- 3.2 Analytic Hierarchy Process (AHP) -- 3.3 Concordance Between Rankings -- 4 Experimental Section -- 5 Results and Discussion -- 6 Conclusions and Future Work -- References -- A Case of Study with the Clustering R Library to Measure the Quality of Cluster Algorithms -- 1 Introduction -- 2 The Clustering Package -- 3 A Case Study Using the Clustering Library on the Dataset of Deaths -- 4 Graphical Distribution of Results -- 5 Conclusions -- References -- Comparing Clustering Techniques on Brazilian Legal Document Datasets -- 1 Introduction -- 2 Related Work -- 3 Theoretical Basis -- 3.1 Clustering Algorithms -- 3.2 Natural Language Processing Techniques -- 4 Methodology -- 4.1 Models Description. , 4.2 Databases, Preprocessing and Embedding -- 4.3 Clustering Evaluation Framework -- 4.4 Clustering Human Evaluation -- 5 Results and Discussion -- 6 Conclusion -- 7 Future Work -- References -- Improving Short Query Representation in LDA Based Information Retrieval Systems -- 1 Introduction -- 2 Material and Methods -- 2.1 Information Retrieval Systems -- 2.2 Latent Dirichlet Allocation -- 2.3 Relevance Estimation -- 3 Proposed Query Representation Method: LDAW -- 3.1 LDAW Calculation Method -- 3.2 Relevance of the Word in Each LDA Topic -- 3.3 Relevance of the Word in the Corpus Vocabulary -- 3.4 Relevance of the Word in the Query -- 3.5 Word Vector Calculation -- 4 Evaluation -- 4.1 Data Sets -- 4.2 Evaluation Measures -- 4.3 Text Pre-processing -- 4.4 Experiments Description -- 5 Results and Discussion -- 6 Conclusions -- References -- A New Game Theoretic Based Random Forest for Binary Classification -- 1 Introduction -- 2 Decision Trees and Random Forests -- 2.1 FROG -- 2.2 RF-FROG -- 3 Numerical Experiments -- 4 Conclusions -- References -- Concept Drift Detection to Improve Time Series Forecasting of Wind Energy Generation -- 1 Introduction -- 2 Materials and Method -- 2.1 Dataset -- 2.2 Concept Drifts Detection Techniques -- 2.3 Comparison Procedure -- 3 Results -- 4 Conclusions -- References -- A Decision Support Tool for the Static Allocation of Emergency Vehicles to Stations -- 1 Introduction -- 2 Background -- 3 Architecture -- 4 Static Ambulance Allocation Model -- 4.1 Problem Description -- 4.2 Mathematical Model -- 5 Evaluation -- 5.1 Computational Evaluation -- 5.2 Model Evaluation -- 6 Conclusions -- References -- Adapting K-Means Algorithm for Pair-Wise Constrained Clustering of Imbalanced Data Streams -- 1 Introduction -- 2 Algorithm -- 3 Experiments -- 3.1 Research Protocol -- 3.2 Experimental Setup -- 3.3 Results. , 4 Conclusions -- References -- Small Wind Turbine Power Forecasting Using Long Short-Term Memory Networks for Energy Management Systems -- 1 Introduction -- 2 Case Study -- 2.1 Sotavento Galicia Building -- 2.2 Dataset Description -- 3 Energy Management System -- 4 Experiments and Results -- 4.1 Experiments Setup -- 4.2 Results -- 5 Conclusions and Future Work -- References -- CORE-BCD-mAI: A Composite Framework for Representing, Querying, and Analyzing Big Clinical Data by Means of Multidimensional AI Tools -- 1 Introduction -- 2 Motivations: Combining Multidimensional AI Tools and Big Clinical Data -- 3 CORE-BCD-mAI: Methodologies and Anatomy -- 4 CORE-BCD-mAI: Research Challenges -- 5 Conclusions and Future Work -- References -- Generalized Fisher Kernel with Bregman Divergence -- 1 Introduction -- 2 Statement of the Problem -- 2.1 Non-parametric Approach -- 3 Non Parametric General Solutions -- 4 Examples -- 5 Conclusion -- References -- A HAIS Approach to Predict the Energy Produced by a Solar Panel -- 1 Introduction -- 2 Case of Study -- 2.1 Sotavento Bioclimatic House -- 2.2 Bioclimatic House Facilities -- 2.3 Solar Thermal System -- 3 Techniques Applied -- 3.1 Statistical Regression Techniques -- 3.2 Artificial Neural Networks -- 3.3 Clustering Technique -- 4 Results and Discussion -- 5 Conclusions and Future Work -- References -- Deep Learning -- Companion Losses for Ordinal Regression -- 1 Introduction -- 2 OR Overview -- 3 Companion Losses for OR -- 4 Experimental Results -- 4.1 Companion Loss Models -- 4.2 Comparison with Classical or Models -- 5 Discussion and Conclusions -- References -- Convex Multi-Task Learning with Neural Networks -- 1 Introduction -- 2 Multi-Task Learning Approaches -- 2.1 Multi-Task Learning with a Feature-Learning Approach -- 2.2 Multi-Task Learning with a Regularization-Based Approach. , 2.3 Multi-Task Learning with a Combination Approach -- 3 Convex MTL Neural Networks -- 3.1 Definition -- 3.2 Training Procedure -- 3.3 Implementation Details -- 4 Experimental Results -- 4.1 Problems Description -- 4.2 Experimental Procedure -- 4.3 Analysis of the Results -- 5 Conclusions and Further Work -- References -- Smash: A Compression Benchmark with AI Datasets from Remote GPU Virtualization Systems -- 1 Introduction -- 2 Related Work -- 2.1 Remote GPU Virtualization -- 2.2 Compression Libraries -- 2.3 Datasets Used with Compression Libraries -- 3 The Smash Compression Benchmark for AI -- 3.1 A New Dataset for AI Applications -- 3.2 The Smash Compression Benchmark -- 4 Experiments -- 5 Conclusion -- References -- Time Series Forecasting Using Artificial Neural Networks -- 1 Introduction -- 2 Background -- 3 Materials and Methods -- 4 ANN Architectures -- 4.1 Multi-layer Neural Network -- 4.2 Recurrent Neural Networks -- 5 Results and Discussion -- 5.1 Recurrent Neural Network Performance -- 5.2 Results Comparison -- 6 Conclusions -- References -- A Fine-Grained Study of Interpretability of Convolutional Neural Networks for Text Classification -- 1 Introduction -- 2 Related Work -- 2.1 Network Interpretability -- 3 Methodology -- 4 Evaluation -- 4.1 Corpora -- 4.2 Model Studied -- 4.3 Experimental Phase -- 4.4 Study of the Interpretability of the Convolutional Layers -- 5 Conclusions and Future Work -- References -- Olive Phenology Forecasting Using Information Fusion-Based Imbalanced Preprocessing and Automated Deep Learning -- 1 Introduction -- 2 Related Works -- 3 Methodology -- 3.1 Data Preparation -- 3.2 Imbalanced Techniques -- 3.3 Automated Deep Learning Proposal -- 3.4 Benchmark Algorithms -- 4 Experimentation and Results -- 4.1 Dataset -- 4.2 Evaluation Metrics -- 4.3 Experimental Settings -- 4.4 Results and Discussion. , 5 Conclusions.
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Pharmaceutical research 9 (1992), S. 1465-1473 
    ISSN: 1573-904X
    Keywords: lipoxygenase ; 5-lipoxygenase inhibitor ; kinetics ; borate catalysis ; N-hydroxyurea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Zileuton (N-(1-benzo[b]thien-2-ylethyl)N-hydroxyurea) is a powerful 5-lipoxygenase inhibitor. The chemical degradation of Zileuton and related hydroxyurea derivatives was studied in aqueous solutions as a function of pH and temperature. The pH profile for the degradation of Zileuton shows an acid-catalyzed region at pH values below 2, water hydrolysis of the protonated form at pH values from 3 to 8, and water hydrolysis of the unprotonated form at pH values greater than 9. Hydrolysis of the hydroxyurea moiety to give the hydroxylamine derivative represents the main degradation pathway for Zileuton. This product, however, is not stable and is present at low concentrations at pH values below 6 and not observed at pH values greater than 7. Further decomposition of the hydroxylamine derivative leads to the observed degradation products. Air oxidation to the isomeric oximes accounts for the observed products at pH values greater than 7. Hydrolysis of the oximes to the ketone derivative accounts for the observed products at pH values 2 to 6. Parallel decomposition pathways to the alcohol derivative were noted under strongly acidic conditions, pH 0 to 2.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-904X
    Keywords: pancreatic lipase ; lipase ; lipolysis ; triglycerides ; kinetics ; mechanism ; calcium ; bile salts ; lecithin ; emulsions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Lecithin-stabilized triglyceride emulsions are subject to hydrolysis by pancreatic lipase. The time profiles of these reactions are characterized by a lag-phase and a zero-order phase. Lag phases are more pronounced with long-chain triglycerides. Ca2+ is effective in reducing the lag-phase and activating lipase. Kinetic analysis of the reactions suggests that, like previous findings by others, taurodeoxycholate (TDC) micellar solutions combine with the lipase–colipase complex to form another catalytically active enzyme form. This enzyme form exhibits reduced activity in the absence of Ca2+. In the presence of Ca2+ the mixed micelle–lipase complex becomes more active and opens a new pathway for lipolysis. It is suggested that this enzyme form can bind more easily to interfaces with different physicochemical properties. Under these conditions, Ca2+ activates the lipolysis of short-, medium-, and long-chain triglycerides by a similar mechanism. Maximum activities were measured in the presence of approximately 6 mM TDC and 30 mM Ca2+. The experimental conditions approximate the physiological conditions in the gastrointestinal tract since all of the factors studied here have been reported to be necessary for in vivo lipolysis and/or absorption of triglycerides. A mechanistic model for lipolysis in the presence of Ca2+ and the bile salt TDC is proposed which accounts for most of the experimental observations in a quantitative manner.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-904X
    Keywords: pancreatic lipase ; lipase, phenytoin ; prodrugs ; prodrug hydrolysis ; emulsions ; micelles ; lipolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Lipase-catalyzed hydrolysis of fatty acid esters of 3-hydroxymethyl phenytoin was studied in various triglyceride and ethyl oleate emulsions, dispersed in micellar solutions, and suspended in an aqueous buffered solution. Phenytoin release from ethyl oleate emulsions of the prodrugs show apparent first-order kinetics with the pentanoate to nonanoate derivatives and sigmoidal kinetics with the long-chain fatty acid derivatives (stearate and oleate). A transition in the kinetic behavior, between the short- and the long-chain acyl prodrugs, was observed with the decanoate derivative. These observations are accounted for by a proposed kinetic model. Phenytoin release from the solid prodrugs follows zero-order kinetics and is independent of the total amounts of suspended material but directly proportional to the lipase concentration. Lipolysis of the solid suspended prodrugs was dependent on the length of the acyl side chain of the prodrug, with maxima for the pentanoate and the octanoate derivatives. The short-chain derivatives, acetate and propionate, as well as the long-chain prodrug, stearate, showed the slowest lipolysis rate when present as solid dispersions. The zero-order rate is qualitatively correlated with the melting point of the prodrugs. This result might be expected if the melting point is taken as a measure of the cohesivity or packing of the molecules at the surface of a crystal.
    Type of Medium: Electronic Resource
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