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  • 1
    Digitale Medien
    Digitale Medien
    Cyanamide mediated syntheses under plausible primitive earth conditions (1977)
    Springer
    Journal of molecular evolution 10 (1977), S. 193-209 
    Details
    ISSN: 1432-1432
    Schlagwort(e): Prebiotic ; Polymerization ; Deoxythymidine oligonucleotides ; Deoxythymidine 5′-triphosphate ; Deoxythymidine 5′-monophosphate ; 4-amino-5-imidazolecarboxamide ; Cyanamide
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary When an aqueous solution (pH 7.0) of3H deoxythymidine 5′-triphosphate, deoxythymidine 5′-phosphate, 4-amino-5-imidazolecarboxamide, cyanamide and ammonium chloride was dried and heated at 60°C for 18 h, oligomers were obtained in a yield of approximately 80%. After the chemical degradation of any pyrophosphate bonds present in these oligomers, linear polynucleotides of up to 7–8 units in length were isolated by DEAE cellulose column chromatography and identified by enzymatic digestion procedures. The di- and trinucleotide fractions were degraded 87% and 100% by snake venom phosphodiesterase and 39% and 9% by spleen phosphodiesterase. This synthesis of deoxythymidine oligonucleotides was conducted under potentially prebiotic conditions and may offer a possible method for the synthesis of deoxyoligonucleotides on the primitive Earth.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01764595
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Cyanamide mediated syntheses under plausible primitive earth conditions (1977)
    Springer
    Journal of molecular evolution 10 (1977), S. 183-192 
    Details
    ISSN: 1432-1432
    Schlagwort(e): Prebiotic ; Polymerization ; Deoxythymidine oligonucleotides ; Deoxythymidine 5′-monophosphate ; P1, P2-dideoxythymidine 5′-pyrophosphate ; 4-amino-5-imidazolecarboxamide ; Cyanamide
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary When an aqueous solution (pH 7.0) of deoxythymidine 5′-phosphate, 4-amino-5-imidazolecarboxamide and cyanamide was dried and heated for 18 h at 60°C, P1, P2-dideoxythymidine 5′-pyrophosphate (I) was formed in a 58% yield. Oligonucleotides were not detected in the reaction product. Under conditions employed in the above reaction, (I) was shown to be stable. In prebiotic polymerization reactions employing deoxythymidine 5′-triphosphate as the polymerizing species, (I) could therefore function as a primer and minimize the formation of cyclic nucleotides.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01764594
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    The prebiotic synthesis of deoxythymidine oligonucleotides (1974)
    Springer
    Journal of molecular evolution 3 (1974), S. 323-330 
    Details
    ISSN: 1432-1432
    Schlagwort(e): Prebiotic ; Polymerization ; Deoxythymidine-Oligonucleotides ; Deoxythymidine-Triphosphate ; Cyanamide ; 4-Amino-5-Imidazolecarboxamide
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary Deoxythymidine 5′-triphosphate in the presence of deoxythmidine 5′-phosphate, cyanamide and 4-amino-5-imidazole carboxamide polymerizes under drying conditions at moderate temperatures (60–90 °C) to yield oligonucleotides of up to four units in length. Enzymatic analysis indicated the majority of these oligomers contained natural 3′–5′ phosphodiester bonds. This reaction offers a possible method for the formation of deoxyoligonucleotides under primitive earth conditions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01796048
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Aggregation effects on male-to-female arrest rate ratios in New York State, 1972 to 1984 (1988)
    Springer
    Journal of quantitative criminology 4 (1988), S. 121-135 
    Details
    ISSN: 1573-7799
    Schlagwort(e): Data disaggregation ; sex convergence ; arrest rates
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Rechtswissenschaft
    Notizen: Abstract The purpose of this paper is to assess the effects of data aggregation on a specification of the relationship between sex and arrest rate trends. The analysis focuses on the empirical implications when arrest data are aggregated across dimensions that are likely to affect the sex-crime relationship. The data for the analysis consist of 4,119,358 male and female adult arrests in New York State for the 13-year period ending in 1984. Results indicate that race, regional differences, and the legal seriousness of the arrest charge produce significantly different patterns of sex convergence across time. On the basis of these results, we suggest serious limitations in past analyses of female crime rates and in the value of Uniform Crime Report (UCR) data for addressing theoretically relevant questions concerning the social correlates of official crime.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01062869
    Standort Signatur Einschränkungen Verfügbarkeit
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