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Power and limits of DNA-profiling in primate populations: Paternity assessment in rhesus macaques from Cayo Santiago (1993)

Krawczak, Michael ; Berard, John D. ; Bercovitch, Fred B. ; [et al.]

Springer

Primates 34 (1993), S. 395-402

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ISSN: 0032-8332

Keywords: DNA fingerprinting ; Oligonucleotides ; Paternity assessment ; Heterozygosity ; Rhesus monkeys

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Abstract Paternity testing was performed in one social group (S) of rhesus macaques from Cayo Santiago, Puerto Rico. In 11/15 cases, sires could be identified comparing the multilocus DNA profiles of 19 males to those of the corresponding mother/child dyads. All 19 males could be excluded from paternity in the remaining four cases. Decision making was partly based on likelihoods of DNA profiles, and the theoretical model underlying these calculation is described. In a second social group (M), held in captivity, paternity testing was impeded by a deficit of maternal bands and by an increased extent of band sharing of mothers and their infants. Some possible explanations for these findings, including increased homozygosity in group M, are discussed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02382635

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A paternity case with apparently conflicting multilocus and single-locus DNA typing results (1997)

Kühnau, Wolfgang ; Böhm, Ingolf ; Krawczak, Michael ; [et al.]

Weinheim : Wiley-Blackwell

Electrophoresis 18 (1997), S. 1598-1601

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ISSN: 0173-0835

Keywords: Paternity testing ; DNA fingerprinting ; Multilocus DNA typing ; Single-locus DNA typing ; (CAC)5-oligonucleotide probe ; Chemistry ; Biochemistry and Biotechnology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Chemistry and Pharmacology

Notes: A paternity case is presented in which DNA typing with thirteen variable number of tandem repeat (VNTR) systems was in apparent conflict with an initial multilocus DNA analysis using oligonucleotide probe (CAC)5. A dual approach was necessary, because the multilocus analysis yielded a proportion of aberrant nonmaternal offspring bands far too small and level of band-sharing too high for non-paternity. The case could finally be solved by reference to the joint likelihood ratio combining both approaches. Arguments are presented that summation of log likelihoods is indeed valid even if no information is available regarding linkage between the VNTR loci and the loci contributing to a multilocus DNA fingerprint.

Additional Material: 2 Ill.