ISSN:
1615-6102
Keywords:
Transferrin
;
Iron transport
;
Cytosol
;
Mammary gland development
;
Involution
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary Cytosol prepared from rat mammary gland contained a glycosylated protein with an estimated molecular weight of 80,000 which comigrated with transferrin upon electrophoretic separation. This protein was recognized specifically by polyclonal antibody to rat transferrin, and had an amino-terminal 17 residue sequence identical to that of rat transferrin. There was a pronounced developmental regulation of cytosolic transferrin levels in mammary gland. During early and mid stages of pregnancy, transferrin accounted for about 1% of cytosolic protein. During late pregnancy, and throughout lactation, transferrin accounted for about 2% of cytosolic protein. Within 2 days after initiation of mammary gland involution, transferrin accounted for more than 15% of cytosolic protein, and then declined during later stages of involution to below 1.5% of cytosolic protein. Pronounced increases in transferrin early in mammary gland involution may serve as a marker for commencement of gland regression.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01403720
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