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  • 1
    Publication Date: 2023-06-16
    Description: Comprehensive management of karst water resources requires sufficient understanding of their dynamics and karst-specific modeling tools. However, the limited availability of observations of karstic groundwater dynamics has been prohibiting the assessment of karst water resources at regional to global scales. This paper presents the first global effort to integrate experimental approaches and large-scale modeling. Using a global soil-moisture monitoring program and a global database of karst spring discharges, the simulations of a preliminary global karstic-groundwater-recharge model are evaluated. It is shown that soil moisture is a crucial variable that better distinguishes recharge dynamics in different climates and for different land cover types. The newly developed dataset of karst spring discharges provides first insights into the wide variability of discharge volumes and recharge areas of different karst springs around the globe. Comparing the model simulations with the newly collected soil-moisture and spring-discharge observations, indicates that (1) improvements of the recharge model are still necessary to obtain a better representation of different land cover types and snow processes, and (2) there is a need to incorporate groundwater dynamics. Applying and strictly evaluating these improvements in the model will finally provide a tool to identify hot spots of current or future water scarcity in the karst regions around the globe, thus supporting national and international water governance.
    Description: Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659
    Keywords: ddc:551.49 ; Karst ; Soil moisture ; Spring discharge analysis ; Groundwater recharge ; Global simulation model
    Language: English
    Type: doc-type:article
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 245 (1998), S. 511-518 
    ISSN: 1432-1459
    Keywords: Key words Secondary dystonias ; Basal ganglia ; Neuroleptics ; Anticholinergics ; Treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Secondary or symptomatic dystonias are (1) often accompanied by other neurological deficits, (2) begin suddenly at rest and occur at rest from the onset, (3) are associated with different hereditary and environmental causes. From an aetiological point of view, secondary dystonias can be caused by focal brain lesions of various origin, neurodegenerative disorders, metabolic disorders of the central nervous system (CNS), and several drugs and chemicals that affect the basal ganglia, thalamus and brain stem. Furthermore, secondary (focal) dystonias can be caused by peripheral injury. In the following review, we will discuss epidemiology, genetics, pathogenesis, neuroimaging, neuropathology, clinical manifestation, clinical course and differential diagnosis of secondary dystonias. Therapeutic options are given depending on the aetiology and the topological type of dystonia.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1619-7089
    Keywords: Coronary artery disease ; Percutaneous transluminal coronary angioplasty ; Noradrenaline depletion ; Metaiodobenzylguanidine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Iodine-123 metaiodobenzylguanidine (MIBG) is a noradrenaline analogue which can be used as a tracer to investigate the cardiac sympathetic nervous system. Regional ischaemia leads to noradrenaline depletion with functional denervation which can be demonstrated by reduced MIBG uptake. In order to evaluate the reversibility of ischaemia-associated damage to the sympathetic nervous system, neuronal scintigraphy with 123I-MIBG and myocardial rest and stress perfusion scintigraphy with technetium-99m sestamibi was performed in 16 patients with coronary artery disease before and 3–4 months after percutaneous transluminal coronary angioplasty (PTCA). Partial re-innervation ocurred in five patients, the degree of stenosis of remaining lesions being estimated by repeat angiography to be below 40%. Unchanged MIBG defects cold be confirmed in four patients with residual lesions of between 40% and 50%. Increased MIBG defects were shown in three patients with significant restenoses of more than 70%. In all patients the neuronal defects exceeded the ischaemia-induced or scar-associated perfusion defects. Three patients dropped out of this study: one for technical reasons, one due to emergency aortocoronary bypass surgery and one due to diabetic polyneuropathy. This investigation shows that the sympathetic nervous system is highly sensitive to ischaemia. Further studies need to be done to assess the conditions allowing re-innervation after PTCA.
    Type of Medium: Electronic Resource
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