ISSN:
1432-069X
Keywords:
Chlorocresol
;
Contact allergy
;
Cyclophosphamide
;
Guinea-pig allergy
;
Suppressor cells
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Chlorocresol was shown to have great potential for contact sensitization in the guinea-pig maximization test at the Day-21 challenge; 2 weeks later, the reactivity was significantly decreased. Cyclophosphamide (250mg/kg) was interperitoneally injected and used as a modulator for the immune response. When cyclophosphamide was administered 3 days before the first challenge, the decrease in reactivity from Day 21 to Day 35 was reversed. This indicates that the reduction in sensitivity was caused by an immunologic mechanism — probably the formation of suppressor cells. This phenomenon is called the “down regulation” of sensitivity and may operate in eczema patients who have lost patch-test reactivity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00414102
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