ISSN:
1619-7089
Keywords:
Key words: Single-photon emission tomography
;
D2 receptors
;
Iodine-123 iodobenzamide
;
Methylphenidate
;
Constant infusion
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract. This double-blind, placebo-controlled study assessed pharmacologically induced endogenous dopamine (DA) release in healthy male volunteers (n=12). Changes in endogenous DA release after injection of the psychostimulant drug methylphenidate were evaluated by single-photon emission tomography (SPET) and constant infusion of iodine-123 iodobenzamide ([123I]IBZM), a D2 receptor radioligand that is sensitive to endogenous DA release. Methylphenidate induced displacement of striatal [123I]IBZM binding, resulting in a significantly decrease in the specific to non-specific [123I]IBZM uptake ratio (average: 8.6%) in comparison with placebo (average: −1.9%). Moreover, injection of methylphenidate induced significant behavioural responses on the following items: excitement, anxiety, tension, and mannerisms and posturing. The results of this study demonstrate the feasibility of using constant infusion of [123I]IBZM and SPET imaging to measure endogenous DA release after methylphenidate challenge and to investigate neurochemical aspects of behaviour.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00841408
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