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  • Synergism  (2)
  • Condensed Matter: Electronic Properties, etc.  (1)
  • Infection, experimental  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Antibiotic C3368-A, a fungus-derived nucleoside transport inhibitor, potentiates the activity of antitumor drugs (1995)
    Springer
    Cancer chemotherapy and pharmacology 36 (1995), S. 149-154 
    Details
    ISSN: 1432-0843
    Keywords: Key Words CA ; Nucleoside transport inhibitor ; Synergism ; Antitumor-drug activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Antibiotic C3368-A (CA) is produced by a fungus strain from a soil sample collected in Antarctica. CA markedly inhibited radiolabeled thymidine and uridine transport in mouse Ehrlich carcinoma cells, its 50% inhibitory concentration (IC5 0) being 4.6 and 7.7 μM, respectively. In clonogenic assay, CA displayed a synergistic effect with methotrexate (MTX), mitomycin C (MMC), 5-fluorouracil (5FU), and Adriamycin (ADR) against human oral epidermoid carcinoma KB cells. CA also markedly enhanced the inhibitory effect of 5FU and ADR on the proliferation of human hepatoma BEL-7402 cells as determined by the p-nitrophenyl-N-acetyl-β-D-glucosaminide (NAG) enzyme-reaction assay. 5FU or ADR cytotoxicity was not augmented by CA in human fetal lung 2BS cells. In vivo, CA significantly potentiated the inhibitory effect of MMC against colon carcinoma 26 in mice. No significant augmentation of toxicity by the combination was found in treated mice. The results suggest that CA, the newly found nucleoside-transport inhibitor, may be useful in potentiation of the effect of antitumor drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00689200
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Antibiotic C3368-A, a fungus-derived nucleoside transport inhibitor, potentiates the activity of antitumor drugs (1995)
    Springer
    Cancer chemotherapy and pharmacology 36 (1995), S. 149-154 
    Details
    ISSN: 1432-0843
    Keywords: CA ; Nucleoside transport inhibitor ; Synergism ; Antitumor-drug activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Antibiotic C3368-A (CA) is produced by a fungus strain from a soil sample collected in Antarctica. CA markedly inhibited radiolabeled thymidine and uridine transport in mouse Ehrlich carcinoma cells, its 50% inhibitory concentration (IC50) being 4.6 and 7.7 μM, respectively. In clonogenic assay, CA displayed a synergistic effect with methotrexate (MTX), mitomycin C (MMC), 5-fluorouracil (5FU), and Adriamycin (ADR) against human oral epidermoid carcinoma KB cells. CA also markedly enhanced the inhibitory effect of 5FU and ADR on the proliferation of human hepatoma BEL-7402 cells as determined by thep-nitrophenyl-N-acetyl-β-d-glucosaminide (NAG) enzyme-reaction assay. 5FU or ADR cytotoxicity was not augmented by CA in human fetal lung 2BS cells. In vivo, CA significantly potentiated the inhibitory effect of MMC against colon carcinoma 26 in mice. No significant augmentation of toxicity by the combination was found in treated mice. The results suggest that CA, the newly found nucleoside-tranport inhibitor, may be useful in potentiation of the effect of antitumor drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00689200
    Location Call Number Limitation Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Human hepatitis B virus and hepatocellular carcinoma I. Experimental infection of tree shrews with hepatitis B virus (1996)
    Springer
    Journal of cancer research and clinical oncology 122 (1996), S. 283-288 
    Details
    ISSN: 1432-1335
    Keywords: Hepatitis B virus ; Infection, experimental ; Tree shrews ; HB vaccine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tree shrews (Tupaia belangeri chinenesis) can be experimentally infected with human hepatitis B virus (HBV) by inoculation with human serum positive for HBV, the experimental infection rate being 55.21%. Successive infections have been passed through five generations among the tree shrews inoculated with HBV-positive sera from the infected animals, the average infection rate being 94.0%. The experimental infection of tree shrews with HBV may be prevented by immunization with hepatitis B vaccine, the protection rate being 88.89%. Standard serum containing HBV at 108 CID (chimpanzee infection dose)/ml, was diluted 10−6, 10−7, 10−8, 10−9, and 10−10 and produced infection rates of 80.0%, 88.8%, 66.7%, 55.6% and 42.9% respectively. Thus the CID50 in tree shrews may reach a dilution of 10−9, which shows that tree shrews are sensitive to HBV infection. These results successfully establish tree shrews as a reliable and useful animal model for research on HBV infection and its relation to hepatocarcinogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01261404
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    Paper (German National Licenses)
    Fulltext
  • 4
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    Unknown
    Terahertz Conductivity of Twisted Bilayer Graphene (2013)
    American Physical Society (APS)
    Details
    Publication Date: 2013-02-08
    Description: Author(s): Xingquan Zou, Jingzhi Shang, Jianing Leaw, Zhiqiang Luo, Liyan Luo, Chan La-o-vorakiat, Liang Cheng, S. A. Cheong, Haibin Su, Jian-Xin Zhu, Yanpeng Liu, Kian Ping Loh, A. H. Castro Neto, Ting Yu, and Elbert E. M. Chia Using terahertz time-domain spectroscopy, the real part of optical conductivity [ σ 1 ( ω )] of twisted bilayer graphene was obtained at different temperatures (10–300 K) in the frequency range 0.3–3 THz. On top of a Drude-like response, we see a strong peak in σ 1 ( ω ) at ∼2.7  THz. We analyze the overall ... [Phys. Rev. Lett. 110, 067401] Published Thu Feb 07, 2013
    Keywords: Condensed Matter: Electronic Properties, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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