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  • kinetics  (2)
  • pancreatic lipase  (2)
  • Computational intelligence-Congresses.  (1)
  • 1
    Keywords: Computational intelligence-Congresses. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (676 pages)
    Edition: 1st ed.
    ISBN: 9783031180507
    Series Statement: Lecture Notes in Networks and Systems Series ; v.531
    DDC: 929.605
    Language: English
    Note: Intro -- Preface -- Organization -- General Chair -- International Advisory Committee -- Program Committee Chairs -- Program Committee -- Special Sessions -- Machine Learning and Computer Vision in Industry 4.0 -- Program Committee -- Time Series Forecasting in Industrial and Environmental Applications -- Program Committee -- Optimization, Modeling, and Control by Soft Computing Techniques -- Program Committee -- Soft Computing Applied to Renewable Energy Systems -- Program Committee -- Preprocessing Big Data in Machine Learning -- Program Committee -- Tackling Real-World Problems with Artificial Intelligence -- Program Committee -- SOCO 2022 Organizing Committee Chairs -- SOCO 2022 Organizing Committee -- Contents -- Decision Support and Deep Learning -- Anomaly Detection of Security Threats to Cyber-Physical Systems: A Study -- 1 Introduction -- 2 Statistical Analysis -- 3 Literature Analysis -- 3.1 CPS Security Design -- 3.2 Anomaly Detection/Threat Detection in CPS -- 4 Outstanding Challenges -- 5 Conclusions -- References -- Predictive Maintenance for Maintenance-Effective Manufacturing Using Machine Learning Approaches -- 1 Introduction -- 2 State-of-the-Art -- 3 Training/Testing Dataset -- 4 Proposed Methodology -- 4.1 Gradient Boosting Training -- 4.2 Support Vector Machine Training -- 5 Results and Discussion -- 6 Conclusions -- References -- Estimation of Lamb Weight Using Transfer Learning and Regression -- 1 Introduction -- 2 Image Acquisition and Data Preparation -- 3 Proposed Architecture -- 4 Experimental Results -- 5 Conclusions -- References -- UAV Simulation for Object Detection and 3D Reconstruction Fusing 2D LiDAR and Camera -- 1 Introduction -- 2 Related Works -- 3 Simulation Framework -- 4 Proposed Process -- 5 Demonstration and Evaluation -- 6 Conclusions and Perspectives -- References. , A SO2 Pollution Concentrations Prediction Approach Using Autoencoders -- 1 Introduction -- 2 Database -- 3 Methodology -- 4 Results -- 5 Conclusions -- References -- CPU Computation Influence on Energy Consumption Forecasting Activities of a Building -- 1 Introduction -- 2 Methodology -- 3 Case Study and Results -- 3.1 Case Study -- 3.2 Results -- 4 Conclusions -- References -- Python-Based Ecosystem for Agent Communities Simulation -- 1 Introduction -- 2 Related Works -- 3 Proposed Solution -- 3.1 PEAK Multi-agent System Platform -- 3.2 Management -- 4 Case Study -- 5 Conclusion -- References -- Deep Learning Approach for the Prediction of the Concentration of Chlorophyll ɑ in Seawater. A Case Study in El Mar Menor (Spain) -- 1 Introduction -- 2 Area Description and Datasets -- 3 Methods -- 3.1 Artificial Neural Networks -- 3.2 Bayesian Regularized Neural Networks -- 3.3 Long Short-Term Memory Neural Networks -- 3.4 Mutual Information -- 3.5 Minimum-Redundancy-Maximum-Relevance (mRMR) -- 4 Experimental Procedure -- 4.1 Creation of the Lagged Datasets -- 4.2 Forecasting Models -- 5 Results and Discussion -- 6 Conclusions -- References -- Evolutionary Computing -- A Hybrid Discrete Symbiotic Organisms Search Algorithm and List-Based Simulated Annealing Algorithm for Traveling Salesman Problem -- 1 Introduction -- 2 A Discrete Symbiotic Organisms Search Algorithm for TSP -- 2.1 Mutualism Phase -- 2.2 Commensalism Phase -- 2.3 Parasitism Phase -- 3 A List-Based Simulated Annealing Algorithm for TSP -- 4 A Hybrid DSOS-LBSA Algorithm for TSP -- 5 Computational Results and Discussion -- 5.1 Parameter Settings -- 5.2 Computational Results and Analysis -- 6 Conclusion and Future Work -- References -- Estimation of Distribution Algorithms Applied to the Next Release Problem -- 1 Introduction -- 2 Next Release Problem -- 2.1 Related Work. , 2.2 Multi-objective Next Release Problem -- 3 Proposal: Univariate EDAs for the MONRP -- 3.1 MONRP-UMDA -- 3.2 MONRP-PBIL -- 4 Experimental Evaluation -- 4.1 Algorithms -- 4.2 Datasets -- 4.3 Methodology -- 5 Results and Analysis -- 5.1 Best Configurations -- 5.2 Pareto Front Results -- 5.3 Metrics Results -- 6 Conclusions and Future Works -- References -- An Extremal Optimization Approach to the Pairwise Connectivity Critical Node Detection Problem -- 1 Introduction -- 2 Related Work and Problem Formulation -- 3 Extremal Optimization -- 4 Numerical Experiments -- 5 Conclusions -- References -- Neural Networks and Data Mining -- Dimensional Reduction Applied to an Intelligent Model for Boost Converter Switching Operation -- 1 Introduction -- 2 Case Study -- 3 Model Approach -- 3.1 Dataset -- 3.2 Methods -- 3.3 Classification Model -- 3.4 Experiments Description -- 4 Results -- 5 Conclusions and Future Works -- References -- Intuitionistic Fuzzy Sets in J-CO-QL+? -- 1 Introduction -- 2 Background -- 2.1 Classical Fuzzy Sets -- 2.2 Intuitionistic Fuzzy Sets and Relations -- 2.3 Example: Representing Medical Knowledge -- 3 Intuitionistic Fuzzy Sets and J-CO-QL+ -- 3.1 J-CO-QL+ Data Model and Execution Model -- 3.2 J-CO-QL+ Script -- 4 Learned Lessons and Conclusions -- References -- Assessing the Efficient Market Hypothesis for Cryptocurrencies with High-Frequency Data Using Time Series Classification -- 1 Introduction -- 2 Literature Review -- 3 Methods -- 4 Experiments and Results -- 4.1 Datasets Used -- 4.2 Experimental Settings and Performance Measures -- 4.3 Results -- 5 Conclusions -- References -- Blockchain for Supply Chain Traceability with Data Validation -- 1 Introduction -- 2 Related Work -- 3 Blockchain-Based GSC Traceability -- 4 Smart Contract for GSC Traceability -- 5 Smart Contract Implementation and Performance Evaluation. , 6 Conclusions and Future Work -- References -- Compression of Clustered Ship Trajectories for Context Learning and Anomaly Detection -- 1 Introduction -- 2 Background Information -- 2.1 Data Pre-processing and Data Imbalance -- 2.2 Trajectory Clustering -- 2.3 Trajectory Compression -- 3 Proposed Architecture -- 3.1 Data Preparation and Cluster Generation -- 3.2 Compression of Trajectories -- 3.3 Representative Points Extraction -- 4 Results Analysis -- 5 Conclusions and Perspectives -- References -- DR Participants' Actual Response Prediction Using Artificial Neural Networks -- 1 Introduction -- 2 Proposed Methodology -- 3 Case Study -- 4 Results and Discussion -- 5 Conclusion -- References -- Non-linear Neural Models to Predict HRC Steel Price in Spain -- 1 Introduction and Previous Work -- 2 Materials and Methods -- 2.1 Dataset -- 2.2 Non-lineal Neural Models -- 3 Experiments and Results -- 4 Conclusions and Future Work -- References -- Soft Computing Applications -- First Steps Predicting Execution of Civil Works from Georeferenced Infrastructure Data -- 1 Introduction -- 1.1 State of the Art -- 1.2 Research Proposal -- 2 Methodology -- 2.1 Preprocess -- 2.2 Data Analysis -- 2.3 Dataset Generation -- 2.4 Supervised Classification -- 2.5 Evaluation -- 2.6 Results -- 3 Conclusion -- References -- Virtual Sensor to Estimate Air Pollution Heavy Metals Using Bioindicators -- 1 Introduction -- 2 Database -- 3 Methodology -- 4 Results -- 5 Conclusions -- References -- Regression Techniques to Predict the Growth of Potato Tubers -- 1 Introduction -- 2 Previous Work -- 3 Regression Techniques -- 3.1 Multiple Linear Regression -- 3.2 Multilayer Perceptron -- 3.3 Radial-Basis Function Network -- 3.4 Support Vector Machine -- 4 Materials and Methods -- 5 Results and Discussion -- 6 Conclusions and Future Work -- References. , Reliability-Sensitive Optimization for Provision of Ancillary Services by Tempo-Spatial Correlated Distributed Energy Resources -- 1 Introduction -- 2 Multivariate Correlation Modeling -- 2.1 Pair-Copula Construction -- 2.2 D-Vine Copula Structure -- 3 Reliability-Sensitive Optimization -- 3.1 Multivariate Correlation Modeling -- 3.2 Joint Reliability Evaluation Methodology -- 4 Simulation Study -- 5 Conclusion -- References -- Special Session on Machine Learning and Computer Vision in Industry 4.0 -- Predictive Maintenance of ATM Machines by Modelling Remaining Useful Life with Machine Learning Techniques -- 1 Introduction -- 2 Materials -- 3 Methods -- 3.1 Task Definition -- 3.2 Feature Extraction and Selection -- 3.3 Pre-processing -- 3.4 Machine Learning Model -- 3.5 Experimental Procedure -- 4 Results -- 5 PdM Decision Support System for SIMPLE Project -- 6 Conclusions -- References -- The Impact of Content Deletion on Tabular Data Similarity Using Contextual Word Embeddings -- 1 Introduction -- 2 Related Work -- 3 Research Method -- 4 Experiments -- 4.1 Models -- 4.2 Datasets -- 4.3 Results -- 5 Conclusions and Future Work -- References -- Deep Learning-Based Dementia Prediction Using Multimodal Data -- 1 Introduction -- 2 DementiaBank Dataset -- 3 Approach -- 3.1 Audio -- 3.2 Text -- 3.3 Multimodal -- 3.4 Other Approaches -- 4 Evaluation -- 5 Conclusion -- References -- Lightweight Models in Face Attribute Recognition: Performance Under Oclussions -- 1 Introduction -- 2 Related Work -- 3 Description of the System -- 3.1 Models -- 3.2 Datasets -- 4 Experimental Setup -- 4.1 Training -- 4.2 Evaluation -- 5 Evaluation with Masked Faces -- 6 Conclusions and Future Work -- References -- Small Vessel Detection in Changing Seaborne Environments Using Anchor-Free Detectors on Aerial Images -- 1 Introduction -- 2 Related Work -- 2.1 Vessel Detection. , 2.2 Datasets.
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  • 2
    ISSN: 1573-904X
    Keywords: pancreatic lipase ; lipase ; lipolysis ; triglycerides ; kinetics ; mechanism ; calcium ; bile salts ; lecithin ; emulsions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Lecithin-stabilized triglyceride emulsions are subject to hydrolysis by pancreatic lipase. The time profiles of these reactions are characterized by a lag-phase and a zero-order phase. Lag phases are more pronounced with long-chain triglycerides. Ca2+ is effective in reducing the lag-phase and activating lipase. Kinetic analysis of the reactions suggests that, like previous findings by others, taurodeoxycholate (TDC) micellar solutions combine with the lipase–colipase complex to form another catalytically active enzyme form. This enzyme form exhibits reduced activity in the absence of Ca2+. In the presence of Ca2+ the mixed micelle–lipase complex becomes more active and opens a new pathway for lipolysis. It is suggested that this enzyme form can bind more easily to interfaces with different physicochemical properties. Under these conditions, Ca2+ activates the lipolysis of short-, medium-, and long-chain triglycerides by a similar mechanism. Maximum activities were measured in the presence of approximately 6 mM TDC and 30 mM Ca2+. The experimental conditions approximate the physiological conditions in the gastrointestinal tract since all of the factors studied here have been reported to be necessary for in vivo lipolysis and/or absorption of triglycerides. A mechanistic model for lipolysis in the presence of Ca2+ and the bile salt TDC is proposed which accounts for most of the experimental observations in a quantitative manner.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Pharmaceutical research 9 (1992), S. 1465-1473 
    ISSN: 1573-904X
    Keywords: lipoxygenase ; 5-lipoxygenase inhibitor ; kinetics ; borate catalysis ; N-hydroxyurea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Zileuton (N-(1-benzo[b]thien-2-ylethyl)N-hydroxyurea) is a powerful 5-lipoxygenase inhibitor. The chemical degradation of Zileuton and related hydroxyurea derivatives was studied in aqueous solutions as a function of pH and temperature. The pH profile for the degradation of Zileuton shows an acid-catalyzed region at pH values below 2, water hydrolysis of the protonated form at pH values from 3 to 8, and water hydrolysis of the unprotonated form at pH values greater than 9. Hydrolysis of the hydroxyurea moiety to give the hydroxylamine derivative represents the main degradation pathway for Zileuton. This product, however, is not stable and is present at low concentrations at pH values below 6 and not observed at pH values greater than 7. Further decomposition of the hydroxylamine derivative leads to the observed degradation products. Air oxidation to the isomeric oximes accounts for the observed products at pH values greater than 7. Hydrolysis of the oximes to the ketone derivative accounts for the observed products at pH values 2 to 6. Parallel decomposition pathways to the alcohol derivative were noted under strongly acidic conditions, pH 0 to 2.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-904X
    Keywords: pancreatic lipase ; lipase, phenytoin ; prodrugs ; prodrug hydrolysis ; emulsions ; micelles ; lipolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Lipase-catalyzed hydrolysis of fatty acid esters of 3-hydroxymethyl phenytoin was studied in various triglyceride and ethyl oleate emulsions, dispersed in micellar solutions, and suspended in an aqueous buffered solution. Phenytoin release from ethyl oleate emulsions of the prodrugs show apparent first-order kinetics with the pentanoate to nonanoate derivatives and sigmoidal kinetics with the long-chain fatty acid derivatives (stearate and oleate). A transition in the kinetic behavior, between the short- and the long-chain acyl prodrugs, was observed with the decanoate derivative. These observations are accounted for by a proposed kinetic model. Phenytoin release from the solid prodrugs follows zero-order kinetics and is independent of the total amounts of suspended material but directly proportional to the lipase concentration. Lipolysis of the solid suspended prodrugs was dependent on the length of the acyl side chain of the prodrug, with maxima for the pentanoate and the octanoate derivatives. The short-chain derivatives, acetate and propionate, as well as the long-chain prodrug, stearate, showed the slowest lipolysis rate when present as solid dispersions. The zero-order rate is qualitatively correlated with the melting point of the prodrugs. This result might be expected if the melting point is taken as a measure of the cohesivity or packing of the molecules at the surface of a crystal.
    Type of Medium: Electronic Resource
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