ISSN:
1432-069X
Keywords:
Atopic eczema
;
cAMP
;
cGMP
;
Circadian plasma levels
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Plasma cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) taken at distinct times of the day were measured in 45 inpatients with generalized atopic eczema (AE). The results were compared with 34 healthy controls. Female patients not taking oral contraceptives (OC) and male patients revealed significantly higher median levels of cAMP in comparison with the controls (p〈0.002 for males;p〈0.001 for females). No significant cAMP differences were found between patients of either sex adn female controls taking OC. The median cGMP plasma levels did not differ between patients and controls. Both cyclic nucleotides are discussed under the aspectof cAMP as a second messenger of various hormones, reflecting and integrating different responses of the body to AE as a distressing systemic skin disorder.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00585922
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