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  • 1
    ISSN: 1432-0843
    Keywords: Key words Malignant melanoma ; Chemotherapy ; Cisplatin ; Tamoxifen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A phase II study was performed to assess the efficacy and toxicity of the combination of cisplatin (CDDP) and tamoxifen (TAM) in patients with metastatic malignant melanoma (MM). A total of 31 consecutive previously untreated patients with unresectable measurable MM were given 100 mg/m2 CDDP every 21 days and 60 mg TAM every 12 h daily. All courses were given on an outpatient basis. A total of 119 courses of treatment were given. In all, 5 of the 31 patients (16%) had an objective response (95% confidence interval 5.3 – 34%) and 2 (6%) achieved a clinical complete response. The median duration of response was 7 months. The main side effect was gastrointestinal: 13% of the patients experienced grade 3/4 nausea/vomiting. Hematological or neurological toxicities were mild and rare. In conclusion, the combination CDDP-TAM has limited activity in MM, although its toxicity is tolerable. Our results do not allow us to recommend its use for the treatment of MM.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of engineering geology and the environment 58 (2000), S. 99-105 
    ISSN: 1435-9537
    Keywords: Keywords Residual shear strength ; marly soils ; Granada ; Spain ; Mots clés Resistance résiduelle au cisaillement ; Sols marneux ; Grenade ; Espagne
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Résumé L'analyse d'échantillons prélevés dans les séries marneuses du Néogène et du Crétacé des bassins de Grenade et de Guadix (sud-est de l'Espagne) montre une corrélation inverse entre la teneur en argile et l'angle de frottement résiduel. Il a été vérifié que la teneur en carbonates de ces sols a une influence significative sur l'angle de frottement résiduel ; il existe un seuil de 25% de carbonates, au-dessus duquel la valeur de φ′r augmente de 20 à 30°. Il a été prouvé que la présence de smectite comme minéral dominant de la fraction argileuse est la cause d'une faible valeur de résistance résiduelle au cisaillement, ainsi que d'une grande fragilité du matériau dans des essais non consolidés non drainés. Il a été prouvé que le degré de compacité de ces sols et, de ce fait, la porosité initiale, a une influence directe sur l'angle de frottement résiduel φ′r.
    Notes: Abstract The analysis of samples taken from the Neogene and Cretaceous marly series of the Granada and Guadix basins (south east Spain) shows an inverse correlation between the clay content and the residual friction angle. It has been verified that the carbonate fraction of the soil has a significant influence on the residual friction angle; there is a threshold of 25% carbonates, above which the value of φ′r increases from 20 to 30°. It has been proved that the presence of smectitic clay as the dominant constituent produces a low value of residual shear strength, associated with high fragility in unconsolidated undrained tests. It has been proved that the degree of compaction of the soil and therefore the initial porosity, has a direct influence on the effective residual friction angle (φ′r).
    Type of Medium: Electronic Resource
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