ISSN:
0268-2605
Keywords:
Organotin complexes
;
antitumour agents
;
1H NMR spectra
;
aryltin chlorides
;
correction analysis
;
murine P388 leukaemia
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Investigation of the antitumour activity of a series of diorganotin dichloride complexes (4-ZC6H4)2SnCl2·L2, where Z = OMe, Me, F, Cl, and CF3 and L2 = 2,2′-bipyridyl (bipy), 1,10-phenanthroline (phen) and 2-aminomethylpyridine (amp) is reported. A number of these complexex are shown to exhibit reproducible activity in vivo towards P388 lymphocytic leukaemia in mice. 1H NMR data are reported for an extended series of (4-ZC6H4)4Sn and the parent dichlorides (4-ZC6H4)2SnCl2 of the above-mentioned complexes. A correlation is reported between Hammett substituent constants and 1H chemical shift data. Attempts are made to relate the antitumour activity of the complexes to various structural factors. The dependence of antitumour activity on the electronic effect of group Z and the nature of the ligand L2 is demonstrated.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/aoc.590030610
Permalink
