ISSN:
0947-6539
Schlagwort(e):
asymmetric synthesis
;
chiral ligands
;
P ligands
;
permutational isomerization
;
phosphane oxides
;
Chemistry
;
General Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
Whereas oxidative dimerization of each of the lithiated reagents (RP)- and (SP)-tert-butylphenylphosphane oxides 1 Li and 2 Li by means of oxygen in THF at low temperature led cleanly to meso-1,2-di-tert-butyl-1,2-diphenyldiphosphane dioxide (3), the respective nucleophilic substitution reactions of 1 Li and 2 Li with the (RP)- and (SP)-tert-butylphenylphosphinic bromides (4 and 6) in THF under argon led to the corresponding (SP,SP)- and (RP,RP)-12-di-tert-butyl-1,2-diphenyldiphosphane dioxides (5 and 7) in good yields, together with the meso-diphosphane dioxide 3. The structures of 3 and 5 were established by X-ray crystallography. Similarly, the reaction of lithiated (RP)-phosphane oxide 1 Li with diphenylphosphinic bromide (8) or of achiral lithiated diphenylphosphane oxide 10 Li with (RP)-tert-butylphenylphosphinic bromide (4) provided (SP)-tert-butyltriphenyldiphosphane dioxide (9).
Zusätzliches Material:
2 Ill.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/chem.19970031221
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