ISSN:
1573-2568
Keywords:
ANTIOXIDANTS
;
EICOSANOIDS
;
FATTY ACIDS
;
FREE RADICALS
;
INFLAMMATORY BOWEL DISEASE
;
ULCERATIVE COLITIS
;
TRINITROBENZENE SULFONIC ACID
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The intrarectal administration oftrinitrobenzene sulfonic acid in rats induces ulcerativecolitis, which results in histological alterations ofcolonic mucosa, severe modification of the cellularantioxidant defense system, and enhanced production ofinflammatory eicosanoids. This study evaluated theinfluence of different dietary fatty acids, ie,monounsaturated, n-3, and n-3 + n-6 polyunsaturatedfatty acids, on the recovery of the colonic mucosahistological pattern, the cellular antioxidant defensesystem of colon, and PGE2 and LTB4colonic mucosa contents in a model of ulcerative colitisinduced by intrarectal administration of trinitrobenzene sulfonicacid. Administration of dietary n-3 polyunsaturatedfatty acids led to a minimum stenosis score, a higherhistological recovery, lower colon alkaline phosphatase and gamma-glutamyltranspeptidase activities,and lower mucosal levels of PGE2 andLTB4 compared with the other two experimentalgroups. However, glutathione transferase, glutathionereductase, glutathione peroxidase, and catalase activities were lowerin the group treated with n-3 polyunsaturated fattyacids than in the groups fed with either themonounsaturated or the n-6 + n-3 polyunsaturatedenriched diet. We conclude that n-3 polyunsaturatedfatty acids can be administered to prevent inflammationin ulcerative colitis, but they cause a decrease in thecolonic antioxidant defense system, promoting oxidative injury at the site of inflammation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1026655311878
Permalink
