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  • Central nervous system-Congresses.  (1)
  • Gene phylogeny  (1)
  • 1
    Online Resource
    Online Resource
    Chimie et Cerveau. (2016)
    Les Ulis :EDP Sciences,
    Details
    Keywords: Brain chemistry-Congresses. ; Central nervous system-Congresses. ; Neuropharmacology-Congresses. ; Electronic books.
    Description / Table of Contents: No detailed description available for "Chimie et cerveau".
    Type of Medium: Online Resource
    Pages: 1 online resource (215 pages)
    Edition: 1st ed.
    ISBN: 9782759818945
    Series Statement: Chimie Et ... Series
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=5058030
    Language: French
    Note: Intro -- Sommaire -- Avant-propos -- Préface -- Partie 1 Explorer le cerveau pour en comprendre le fonctionnement -- La chimie des récepteurs des neurotransmetteurs -- Imagerie moléculaire de la synapse -- Imagerie fonctionnelle cérébrale -- Fonctionnement du système nerveux : imagerie calcique et optogénétique -- Partie 2 Les pathologies dégénératives du cerveau et leur traitement -- Vieillissement cérébral ou maladie dégénérative -- La molécule et les maladies : protéines infectieuses -- Maladie d'Alzheimer et cibles thérapeutiques : état de l'art -- Partie 3 Les pathologies psychiatriques du cerveau et leur traitement -- Opiacés et cerveau -- Aspect génétique des addictions -- La dépression et ses traitements -- Partie 4 Les apports et enjeux de la chimie dans les neuroscienceset la neuropharmacologie -- Les enjeux de la chimie dans la connaissance du cerveau -- La neuro-pharmacologie: un triomphe dans l'exploration du cerveau, un échec à dépasser dans la création de thérapeutiques innovantes.
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  • 2
    Electronic Resource
    Electronic Resource
    Molecular evolution of the nicotinic acetylcholine receptor: An example of multigene family in excitable cells (1995)
    Springer
    Journal of molecular evolution 40 (1995), S. 155-172 
    Details
    ISSN: 1432-1432
    Keywords: Nicotinic receptor ; Ligand-gated channel ; Multigene family ; Gene phylogeny
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract An extensive phylogenetic analysis of the nicotinic-acetylcholine-receptor subunit gene family has been performed by cladistic and phenetic methods. The conserved parts of amino acid sequences have been analyzed by CLUSTAL V and PHYLIP software. The structure of the genes was also taken in consideration. The results show that a first gene duplication may have occurred before the appearance of Bilateria. Three subfamilies then appeared: I-the neuronal α-bungarotoxin binding-site subunits (α7, α8); III-the neuronal nicotinic subunits (α2–α6, β2–β4), which also contain the muscle acetylcholine-binding subunit (α1); and IV—the muscle non-α subunits (β1, γ δ, ε). The Insecta subunits (subfamily II) could be orthologous to family III and IV. Several tissular switches of expression from neuron to muscle and the converse can be inferred from the extant expression of subunits and the reconstructed trees. The diversification of the neuronal nicotinic subfamily begins in the stem lineage of chordates, the last duplications occurring shortly before the onset of the mammalian lineage. Such evolution parallels the increase in complexity of the cholinergic systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167110
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    Paper (German National Licenses)
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