Note: Front Cover -- Intercellular Signaling in Development and Disease -- Copyright Page -- Editorial Advisory Board -- Contents -- Preface -- Contributors -- Section A: Overview -- Chapter 1: Signaling in Development and Disease -- Origins of Cell Signaling Research -- Receptors and Intracellular Signaling -- Intercellular Signaling -- Focus and Scope of this Volume -- References -- Section B: Cell-Cell Signaling -- Chapter 2: Overview of Cell - Cell and Cell - Matrix Interactions -- References -- Chapter 3: Integrin Signaling: Cell Migration, Proliferation, and Survival -- Introduction -- Integrins Nucleate the Formation of Dynamic Multi-Protein Complexes -- Cell Migration: A Paradigm for Studying Integrin Signaling -- Lamellipodia Extension, and Adhesion Formation and Stabilization at the Leading Edge -- Maturation, Detachment, and Release of Adhesions -- Growth Factor Receptor and Integrin Signaling-Synergistic Regulation of Cell Proliferation and Survival -- Integrin Signals and Links to Cancer -- Concluding Remarks -- Acknowledgements -- References -- Chapter 4: The Focal Adhesion: A Network of Molecular Interactions -- Introduction -- Integrin Activation -- Adhesion Strengthening -- Intracellular Signaling and Molecular Scaffolds -- Focal Adhesion Turnover -- Focal Adhesions and Gene Expression -- The Future -- Acknowledgements -- References -- Chapter 5: Cadherin Regulation of Adhesive Interactions -- Introduction -- The Cadherin Family -- Cadherin Structure - Function Relationships -- Multiple Modes for Regulating Cadherin Adhesive Activity -- Conclusions and Perspectives -- Acknowledgements -- References -- Chapter 6: In vivo Functions of Heterotrimeric G Proteins -- Introduction -- Development -- Central Nervous System -- Immune System -- Heart -- Sensory Systems -- Hemostasis -- Conclusions -- References. , Chapter 7: G-Protein Signaling in Chemotaxis -- Introduction -- Chemotaxis: Membrane Extensions, Directional Sensing, and Polarization -- Chemoattractant Signaling Regulates Multiple Downstream Pathways -- Front and Back Signaling -- Mechanisms of Directional Sensing -- Polarization -- Conclusion -- Acknowledgements -- References -- Chapter 8: Interactive Signaling Pathways in the Vasculature -- Introduction -- Interactive Networks as Models of Cell Signaling -- Cross-Talk Between FGF and Notch Signaling -- Novel Modulators of TGFß Signaling -- Notch, FGF, and Smad Signaling Interactions -- Feedback Inhibitory Mechanisms in Vascular Cell Signaling -- Implications in Vascular Remodeling -- References -- Chapter 9: Signaling Pathways Involved in Cardiogenesis -- Introduction -- Origin of Cardiomyocyte Precursors -- Cardiomyocyte and Heart Tube Formation -- Complex Regulation of Cardiac Morphogenesis -- Molecular Regulation of Septal Formation -- Microrna Regulation of Cardiomyocyte Differentiation -- Summary -- Acknowledgements -- References -- Chapter 10: Calcium Signaling in Cardiac Muscle -- Introduction -- Calcium-Induced Calcium Release -- How is SR Calcium Content Controlled? -- Which Factors Control the Amplitude of the Systolic Calcium Transient? -- Calcium Signaling in Heart Failure -- References -- Chapter 11: Calcium Signaling in Smooth Muscle -- Introduction -- The Role of Calcium Signaling in Smooth Muscle -- Overview of Types of Calcium Signals in Smooth Muscle -- Calcium Entry Mechanisms -- Calcium Efflux Mechanisms -- SR and Calcium Signaling -- Mitochondrial and Other Organellar Contribution to Calcium Signaling -- Global Calcium Transients -- Local Calcium Signals -- Calcium Oscillations and Waves -- Caveolae, Microdomains, and Calcium Signals -- References -- Chapter 12: Trophic Effects of Gut Hormones in the Gastrointestinal Tract. , Introduction -- Trophic Effects of Gut Peptides in the Stomach, Small Bowel, and Colon -- GI Hormone Receptors and Signal Transduction Pathways -- Signaling Pathways Mediating the Effects of Intestinal Peptides -- Conclusions -- Acknowledgements -- References -- Chapter 13: Cell - Cell and Cell - Matrix Interactions in Bone -- Introduction to Bone and Bone Disease -- Diseases of Bone -- Bone Cells and their Functions -- Mechanical Strain -- Hormones Responsible for Bone Development, Growth and Maintenance -- Growth, Signaling, and Transcription Factors Responsible for Bone Development and Growth -- Bone Extracellular Matrix (ECM) -- Conclusion anSummary -- References -- Chapter 14: Cell - Cell Signaling in the Testis and Ovary -- Introduction -- Cell - Cell Signaling in the Testis -- Cell - Cell Signaling in the Ovary -- Summary -- References -- Chapter 15: Kidney -- Overview of Kidney Function and Cell-to-Cell Interactions -- Vascular Smooth Muscle Cells -- Vascular Endothelial Cells -- Vasoactive Paracrine/Autocrine Agents - Actions in the Renal Vasculature -- Endothelial Cell Connections: Connexins and Gap Junctions -- Paracrine Signaling in Renal-Tubule Epithelial Cells -- Interstitial Cell - Tubule Communication -- Conclusions -- Acknowledgements -- References -- Chapter16: Cytokines and Cytokine Receptors Regulating Cell Survival, Proliferation, and Differentiation in Hematopoiesis -- General Aspects of Hematopoiesis -- Hematopoietic Cytokines -- Signaling through Cytokine Receptors -- Concluding Statements -- References -- Chapter 17: CD45 -- Introduction -- Structure -- Function -- Regulation -- Synopsis -- Acknowledgements -- References -- Chapter 18: Signal Transduction in T Lymphocytes -- Introduction -- Signaling Receptors in T Cells form Dynamic Macromolecular Signaling Complexes. , Co-receptor and Co-stimulatory Proteins Modulate T Cell Signaling Pathways -- Intracellular Signaling Pathways Induced by Antigen Stimulation of T Cells -- Conclusions -- References -- Chapter 19: Signal Transduction via the B Cell Antigen Receptor: A Crucial Regulator of B Cell Biology -- Introduction -- Initiation of Signal Transduction through the BCR -- Propagation of Signal Transduction Via the BCR -- Conclusion -- References -- Chapter 20: Signaling Pathways Regulating Growth and Differentiation of Adult Stem Cells -- Introduction -- Stem Cell Properties -- Signaling Intermediates and Pathways in CD133 Stem Cells -- Conclusions -- References -- Section C: Signaling in Development -- Chapter 21: Wnt Signaling in Development -- Introduction -- Canonical Wnt Signaling -- Wnt Signaling in Invertebrate Development -- Wnt Signaling in Vertebrate Development -- Wnt/Planar Cell Polarity -- Acknowledgements -- References -- Chapter 22: Interactions between Wnt/β -Catenin/Fgf and Chemokine Signaling in Lateral Line Morphogenesis -- Introduction -- FGF Signaling Controls Sensory Organ Formation in the Migrating Primordium -- Wnt/ß -Catenin Signaling Restricts Neurogenesis to Trailing Cells and Maintains the Progenitor Zone -- The FGF Pathway Restricts Wnt/ß - Catenin Signaling to the Leading Edge Ensuring Normal Migration -- Chemokine Signaling Guides the Migrating Primordium -- A Feedback Loop Between FGF and Wnt/ß -Catenin Signaling Controls Migration by Localizing Chemokine Receptor Expression -- Cell Migration and Rosettogenesis are Independently Regulated -- Summary -- References -- Chapter 23: Integration of BMP, RTK, and Wnt Signaling Through Smad1 Phosphorylations -- Introduction -- Neural Induction: Linking RTKs and Anti-BMP Signals -- MAPK Activation Explains Heterologous Neural Inducers. , Epidermal Differentiation: Integration of Wnt and BMP Signals -- Smad1 as a Platform for MAPK Integration -- Smad1 as a Platform for Wnt Signals -- A Conserved Mechanism of Signal Integration -- Concluding Remarks -- References -- Chapter 24: Hedgehog Signaling in Development and Disease -- The Hedgehog Proteins: Generation and Distribution -- Transmitting the HH Signal -- HH in Development and Disease -- Acknowledgements -- References -- Chapter 25: Regulation of Vertebrate Left-Right Axis Development by Calcium -- Introduction -- Conserved Molecular Pathways Regulating LR Asymmetry -- Initiating a Break in Symmetry -- Conserved Role of Calcium in Left - Right Asymmetry Determination -- Conclusions -- Acknowledgements -- References -- Chapter 26: LIN-12/Notch Signaling: Induction, Lateral Specification, and Interaction with the EGF/Ras Pathway -- The LIN-12/Notch Pathway -- Inductive Signaling Versus Lateral Specification -- Cellular outcome of the Activation of the LIN-12/Notch Pathway -- Acknowledgement -- References -- Chapter 27: Proteolytic Activation of Notch Signaling: Roles for Ligand Endocytosis and Mechanotransduction -- Introduction -- DSL Ligand Endocytosis is Required for Activation of Notch Signaling -- Ubiquitin and Epsin-Dependent Recycling to Produce an Active DSL Ligand -- Notch Signaling Requires Proteolysis and Nuclear Translocation -- DSL Ligand Endocytosis to Produce a Force for Notch Proteolytic Activation -- Converting DSL Ligand Endocytosis into a Force-Generating Process -- Conclusions and Future Directions -- References -- Chapter 28:Vascular Endothelial Growth Factors and Receptors: Signaling in Vascular Development -- Introduction to Vegfs and VEGF Receptors -- Developmental Processes -- Vasculogenesis and Angiogenesis -- VEGFR2 and its Ligands in Vascular Development. , VEGFR1 and its Ligands in Vascular Development and Inflammatory Responses.