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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 165 (1975), S. 219-225 
    ISSN: 1433-8580
    Keywords: heterotopic ossification ; stomach carcinoma ; nitrosoguanidine ; gastric stump ; Heterotope Verknöcherung ; Carcinom ; resezierter Magen ; Nitrosoguanidin ; Ratte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Heterotope Verknöcherungen treten im Nitrosoguanidin-induzierten Magenstumpfcarcinom der Ratte gehäuft auf. Folgende Differenzierungsstufen der desmalen Knochenbildung wurden gefunden. 1. Osteoblasten. 2. Osteoid. 3. Geflechtartiger Knochen. 4. Lamellärer Knochen. Die metaplastischen Knocheninseln sind vorwiegend in der invasiven Randzone der Magenstumpfcarcinome lokalisiert. Da Analogien zur metaplastischen Knochenbildung im Magencarcinom des Menschen bestehen, eignet sich das hier beschriebene Modell zum Studium der heterotopen Ossifikation.
    Notes: Summary Heterotopic ossifications are found frequently in rats with nitrosoguanidine-induced carcinomas of the gastric stump. The following steps of differentiation of the desmal ossification in the stump carcinomas are demonstrated: 1. Osteoblasts. 2. Osteoid. 3. Woven Bone reticular network. 4. Lamellar bone. The islands of metaplastic bone cells are predominantly located in the invasive marginal area of the carcinoma of the gastric stump. The histology is similar to that one seen in stomach cancer of men. Therefore, the here described model seems to be suitable for further study of the metaplastic bone formation in the gastrointestinal tract.
    Type of Medium: Electronic Resource
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