Keywords:
Carbohydrates.
;
Electronic books.
Type of Medium:
Online Resource
Pages:
1 online resource (196 pages)
Edition:
1st ed.
ISBN:
9780128171486
Series Statement:
Issn Series
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=5726246
DDC:
547.78
Language:
English
Note:
Front Cover -- Sialic Acids, Part II: Biological and Biomedical Aspects -- Copyright -- Contents -- Contributors -- Preface -- References -- Chapter One: Sialic Acids in Neurology -- 1. Introduction -- 2. History, Definition, and Occurrence -- 2.1. History -- 2.2. Definition of Oligo/PolySia -- 2.3. Occurrence -- 3. Analytical Methods -- 3.1. Biochemical Probes -- 3.1.1. Antibodies -- 3.1.2. Enzymes -- 3.2. Chemical Detection Method -- 3.2.1. Fluorometric C7/C9 Analysis -- 3.2.2. Mild Acid Hydrolysis-Fluorescent Anion-Exchange HPLC Analysis -- 3.2.3. Conventional Chemical Methods -- 3.2.4. Chemical Biological Approaches -- 4. Biosynthesis -- 4.1. Common Features -- 4.2. Oligo/PolySia-Biosynthesizing Enzymes: ST8Sia2, ST8Sia4, and ST8Sia3 -- 4.3. Di/TriSia-Synthesizing Enzymes: ST8Sia1, ST8Sia5, and ST8Sia6 -- 5. Phenotypes of PolySia-Impaired Animals -- 6. Biochemical Features of Di/Oligo/PolySia and Their Functions -- 6.1. Repulsive Field of PolySia -- 6.2. Attractive Field of PolySia -- 6.2.1. Neurotrophic Factors -- 6.2.2. Growth Factors -- 6.2.3. Neurotransmitters and Ions -- 6.2.4. Cytokines -- 6.2.5. Transcription Factors -- 6.3. Regulatory Role for Receptors -- 6.3.1. Ion and Ion Channel -- 6.3.2. Siglecs -- 6.3.3. Other Molecules -- 7. Related Diseases -- 7.1. Mental Disorders and Neurodegenerative Diseases -- 7.2. Cancer -- 8. Perspectives -- Acknowledgments -- References -- Chapter Two: Sialic Acids in Nonenveloped Virus Infections -- 1. Sialic Acids as Viral Receptors-One Term, Many Functions -- 2. Identification of Sialic Acid as a Determinant of Infection -- 2.1. Hemagglutination Assays -- 2.2. Neuraminidase Treatment -- 2.3. Inhibition of Glycosylation -- 2.4. Sialic Acid-Deficient Cell Lines -- 2.5. Discrepancies Between In Vivo and In Vitro ``Receptors´´ -- 2.6. Other Experiments.
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3. Identification of Specific Sialylated Receptor Candidates -- 3.1. Glycan Arrays for Verification of Receptor Glycan Specificity -- 3.2. STD NMR Spectroscopy for Verification of Receptor Glycan Specificity -- 3.3. Affinity Measurements -- 3.4. Differentiating Between Glycolipids and Glycoproteins -- 4. Atomic Resolution Structures of Sialic Acid-Virus Interactions and Structure-Based Inhibitor Design -- 4.1. General Aspects of Virus-Glycan Structural Biology -- 4.2. Single Virus Families -- 4.2.1. Polyomaviruses -- 4.2.2. Reoviruses -- 4.2.3. Adenoviruses -- 4.2.4. Picornaviruses -- 4.3. Structure-Based Inhibitors -- 5. Outlook: The Microbiome in Enteric Virus Infections -- Acknowledgments -- References -- Chapter Three: The Biology of Gangliosides -- 1. Ganglioside Structures, Distribution, and Biosynthesis -- 2. Ganglioside Functions: cis Regulation and trans Recognition -- 3. Gangliosides Regulate Receptor Tyrosine Kinases -- 4. Gangliosides Impact Human Proteinopathies -- 5. Gangliosides Are Cell-Surface Receptors for Bacterial Toxins -- 6. Gangliosides Are Cell-Surface Receptors for Myelin-Associated Glycoprotein -- 7. Intellectual Disability and Seizures in Humans and Mice With Altered Ganglioside Biosynthetic Genes -- 8. Gangliosides in Human Disease -- Acknowledgments -- References -- Author Index -- Subject Index -- Back Cover.
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