ISSN:
0170-2041
Keywords:
Heptose oligosaccharides
;
Kdo oligosaccharides
;
Lipopolysaccharides
;
Antigens, synthetic
;
Oligosaccharides
;
Carbohydrates
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Building Units of Oligosaccharides, IC. - Preparation of Synthetic Antigens of the Inner Core Region of Lipopolysaccharides by Copolymerisation with AcrylamideBesides L-α-D-Hepp-OAll (5), the following allyl glycosides with oligosaccharide structures of the inner core region of lipopolysaccharides have been synthesized: L-α-D-Hepp-(1→7)-L-α-D-Hepp-OAll (19), L-α-D-Hepp-(1→3)-L-α-D-Hepp-OAll (26), L-α-D-Hepp-(1→5)-α-Kdop-OAll (31), L-α-D-Hepp-(1→5)-β-Kdop-OAll (34), L-α-D-Hepp-(1→5)-[α-Kdop-(2→4)]-α-Kdop-OAll (48) and L-α-D-Hepp-(1→5)-[α-Kdop-(2→4)]-β-Kdop-OAll (39). All these compounds have been coupled with cysteamine to the spacer-elongated derivatives 54b - 60b and finally converted into the acryloyl compounds 54c - 60c. The copolymerisation of 54c - 60c with acrylamide gave the polymers 54d - 60d, containing the above mentioned oligosaccharides as haptens in an antigenic form.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.1991199101196
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