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Structure-based design of potent CDK1 inhibitors derived from olomoucine (2000)

Furet, Pascal ; Zimmermann, Juerg ; Capraro, Hans-Georg ; [et al.]

Springer

Journal of computer aided molecular design 14 (2000), S. 403-409

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ISSN: 1573-4951

Keywords: cyclin-dependent kinase ; CDK1 ; inhibitor ; olomoucine ; structure-based design

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract Cyclin-dependent kinase 1 (CDK1), an enzyme participating in the regulation of the cell cycle, constitutes a possible target in the search for new antitumor agents. Starting from the purine derivative olomoucine and following a structure-based approach, potent inhibitors of this enzyme were rapidly identified. The molecular modeling aspects of this work are described.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1008115004986

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