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  • 1
    Electronic Resource
    Electronic Resource
    Relationship between plasma delta-9-tetrahydrocannabinol concentration and pharmacologic effects in man (1981)
    Springer
    Psychopharmacology 75 (1981), S. 158-164 
    Details
    ISSN: 1432-2072
    Keywords: Tetrahydrocannabinol ; Pharmacodynamics ; Hysteresis plots ; Tachycardia ; Intoxication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between each of two pharmacologic effects (tachycardia and psychological “high”) of delta-9-tetrahydrocannabinol (THC) and plasma THC concentration was investigated in three male and three female experienced marihuana smokers. Each subject smoked one 1% THC cigarette on two occasions separated by 2 h. Heart rate and subjective psychological self-rating were determined frequently throughout the 4 h study period. Data were analyzed by calculating the area under the parameter versus time curves, constructing hysteresis plots, and calculating the decay rate constants from pharmacologic effect versus time plots. In both males and females, dose inhaled and psychological response were apparently equivalent for the first and second cigarettes. While all subjects exhibited marked tachycardia in response to the first cigarette, heart rate in both male and female subjects was not increased as markedly during the second cigarette. Interestingly, female subjects had less tachycardiac response than males during the second cigarette. Hysteresis plots revealed that both heart rate and subjective psychological effects were elicited in an effect compartment which was “deep” relative to the reference plasma compartment. The time courses of tachycardiac and psychological responses lagged behind the plasma THC concentration-time profile. Zero-order decay rate constants for subjective psychological rating did not change substantially from the first to second cigarette. This study suggests that plasma THC concentration is a poor predictor of simultaneously occurring physiological and psychological pharmacologic effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432179
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Embryology and breeding systems inCrocus (Iridaceae)—a study in causes of chromosome variation (1984)
    Springer
    Plant systematics and evolution 148 (1984), S. 119-134 
    Details
    ISSN: 1615-6110
    Keywords: Angiosperms ; Iridaceae ; Crocus ; C. speciosus ; Embryo sac ; intraspecific hybrids ; chromosome numbers ; karyotypes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A detailed description of female reproductive structures inCrocus is given, using three different techniques: wax embedding and sectioning, SEM, and observation of cleared ovules by interference contrast microscopy. The results of this examination, and a chromosomal investigation of the intraspecific hybrids obtained by crossing specimens ofC. speciosus of different karyotypes, are used to test the hypothesis thatCrocus is apomictic. Although facultative diplospory cannot be entirely ruled out, it is suggested that apomixis is an unlikely explanation from the unusual amount of chromosomal variation found in some species ofCrocus, and alternative causes are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00984573
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    Paper (German National Licenses)
    Fulltext
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