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  • Breast cancer  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Cancer following breast reduction surgery in Denmark (1997)
    Springer
    Cancer causes & control 8 (1997), S. 253-258 
    Details
    ISSN: 1573-7225
    Keywords: Breast cancer ; breast reduction surgery ; cohort study ; Denmark
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intuitively, breast tissue mass should be directly related to a woman'srisk of breast cancer, simply because having more cells at risk would seem toincrease the potential for malignant transformation. However, studiesattempting to link breast size with breast cancer risk have beeninconsistent. Limitations include crude measures of breast size, theinability to distinguish glandular from adipose tissue, and the confoundinginfluence of co-factors such as obesity. A nationwide study in Denmark wasundertaken to investigate the effect of breast reduction surgery on thesubsequent risk of breast cancer, including an evaluation of the patterns ofrisk by age and time since surgery. The Danish Hospital Discharge Registrywas used to identify women who underwent reduction mammaplasty between 1977and 1992. Linkage based on personal identification numbers with the DanishCancer Registry provided information on cancer incidence. Expected numbers ofcancers were calculated from rates in the general population. Among 7,720women whose breasts were surgically reduced, 182 cancers were subsequentlyobserved cf 209 expected (standardized incidence ratio [SIR] = 0.9; 95percent confidence interval [CI] = 0.7-1.0). Breast cancer was significantlyreduced by nearly 50 percent (29 observed cf 53.9 expected, SIR = 0.5, CI =0.4-0.8), and accounted for the overall deficit in cancer. The riskreductions were related inversely to age at surgery, with significantdeficits apparent only among women 40 years of age and older at surgery andespecially among those over age 50 (SIR = 0.3). No clear trend was apparentwith increasing years post-surgery. The findings indicate that breastreduction surgery among women over age 40 is associated with a lowersubsequent risk of breast cancer, but the surgery and presumably glandularmass appear less closely related to breast cancer risk among youngerwomen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018484616598
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Reduced risk of breast and endometrial cancer among women with hip fractures (Sweden) (1994)
    Springer
    Cancer causes & control 5 (1994), S. 523-528 
    Details
    ISSN: 1573-7225
    Keywords: Breast cancer ; endometrial cancer ; estrogens ; hip fractures ; Sweden
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To test the hypothesis that osteoporosis, which results partly from long-term estrogen deficiency, is associated with a lowered risk of breast and endometrial cancer, a population-based cohort study was performed in Sweden. Some 18,000 women were followed through record-linkages after a first hip fracture, on average for almost six years, to ascertain the incidence of breast and endometrial cancer. Expected numbers were derived from the general population. Overall, 253 cases of breast cancer were observedcf 300 expected (standardized incidence ratio [SIR]=0.84; 95 percent confidence interval [CI]=0.74–0.95). Forty-eight cases of endometrial cancer were foundcf 55 expected (SIR=0.87, CI=0.54–1.16). There was no clearcut pattern of breast cancer risk by age at diagnosis of hip fracture, follow-up time, or calendar period. Our results are consistent with thea priori hypothesis that long-term estrogen deficiency is associated with a reduced risk of developing breast cancer as well as endometrial cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01831380
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Risk for endometrial cancer following breast cancer: a prospective study in Sweden (1997)
    Springer
    Cancer causes & control 8 (1997), S. 821-827 
    Details
    ISSN: 1573-7225
    Keywords: Breast cancer ; endometrial cancer ; Sweden ; tamoxifen ; women
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The risk for endometrial cancer among women with breast cancer might increase following use of tamoxifen, recently classified as a carcinogen of the human endometrium. However, the strength of the association remains uncertain and it is unknown whether use of this drug - widely prescribed in Sweden since the mid-1980s - has had any measurable effect at the population level. We analyzed all cases of breast cancer (n = 131,614) detected in the nationwide Swedish Cancer Registry in 1958-93. Incident cases of endometrial cancer during follow-up were identified also through the Cancer Registry. Standardized incidence ratios (SIR) and their 95 percent confidence intervals(CI) were computed by use of nationwide rates of endometrial cancer, adjusted for age and calendar year. During follow-up of up to 35 years of the breast cancer cohort, 803 incident endometrial cancers were identified, yielding an overall SIR of 1.58 (CI = 1.47-1.70). In univariate analyses, there was no increase in SIR in recent years. However, the excess risk increased linearly with increasing age at breast cancer diagnosis (P trend 〈 0.0001) and decreased markedly with longer follow-up (P trend 〈 0.0001). A multivariate regression analysis, with adjustment for age and year of follow-up, revealed no increased risk for subsequent endometrial cancer among breast cancer cases diagnosed more recently (P trend = 0.19); compared with the period 1958-63,the risk estimate in the last time period (1989-93) was 0.72 (CI =0.51-1.01). We conclude that the risk for endometrial cancer following breast cancer has not increased over time in Sweden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018404110180
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    Paper (German National Licenses)
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