ISSN:
1432-1920
Keywords:
Metrizamide
;
Conray
;
Dimer X
;
Subacute inflammatory reactions
;
Brain edema
;
Ultrastructure
;
Arachnoid granulation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Adult New Zealand rabbits were injected intrathecally with 200 or 300 mgI/ml of metrizamide, meglumine iocarmate or meglumine iothalamate. They were placed in the Trendelenburg position for 20 min and allowed to survive for 1, 2 or 3 weeks. Sacrifice was by intraarterial perfusion of aldehydes under anesthesia followed by preparation of brain and major venous sinuses for light and electron microscopy. Major findings were subpial edema and inflammatory reaction of superficial brain, leptomeninges, subarachnoid space and arachnoid granulations. They were most severe after iothalamate and milder after metrizamide. The severity decreased with time. It is of significance that severe reactions occurred after 300 mg I/ml concentration of metrizamide.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00342089
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