Schlagwort(e):
Biochemistry.
;
Electronic books.
Materialart:
Online-Ressource
Seiten:
1 online resource (358 pages)
Ausgabe:
1st ed.
ISBN:
9780128099841
Serie:
Issn Series
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=4732264
DDC:
547.78
Sprache:
Englisch
Anmerkung:
Front Cover -- Advances in Carbohydrate Chemistry and Biochemistry -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Stevia Glycosides: Chemical and Enzymatic Modifications of Their Carbohydrate Moieties to Improve the Sweet- ... -- 1. Introduction -- 2. Steviol Glycoside Structures from S. rebaudiana -- 3. Steviol Variants of Glycoside Structures from S. rebaudiana -- 4. Stability of Steviol Glycosides -- 5. Structure-Sweetness Relationship -- 6. Chemical Modifications of Steviol Glycosides -- 7. Enzymatic Modifications of Steviol Glycosides -- 7.1. Cyclodextrin Glycosyl Transferase Systems -- 7.2. α-Glucosidase Transglycosylation Systems -- 7.3. β-Glucosidase Transglycosylation and Deglycosylation Systems -- 7.4. α-Galactosidase Transglycosylation Systems -- 7.5. β-Galactosidase Transglycosylation Systems -- 7.6. β-Fructosidase Transglycosylation Systems -- 7.7. β-Glycosyltransferase Glycosylation Systems Using UDP-Sugars -- 8. Patents Regarding Enzymatic Modifications of Steviol Glycosides -- 9. Concluding Remarks -- Addendum -- Acknowledgments -- References -- Chapter Two: Endoglycosidases for the Synthesis of Polysaccharides and Glycoconjugates -- 1. Introduction -- 1.1. Biological Functions of Glycans and Glycoconjugates -- 1.2. Synthetic Glycans and Glycoconjugates for Deciphering Functions -- 1.3. Enzymes as a Tool for the Synthesis of Glycans and Glycoconjugates -- 2. Endoglycosidases in the Synthesis of Natural and Artificial Polysaccharides -- 2.1. Synthesis of Artificial Cellulose and Derivatives via Enzymatic Polymerization of Glycosyl Fluorides Catalyzed by Ce ... -- 2.2. Chitinase-Catalyzed Synthesis of Artificial Chitin and Derivatives Using Sugar Oxazolines as Activated Substrates -- 2.3. Hyaluronidase-Catalyzed Construction of Glycosaminoglycans Using Sugar Oxazoline as the Activated Substrates.
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2.4. Endo-β-Xylosidase-Catalyzed Transglycosylation in the Synthesis of Proteoglycans -- 3. Endoglycosidases in the Synthesis of N-Glycopeptides and N-Glycoproteins -- 3.1. Exploration of Glycan Oxazolines as Donor Substrates for ENGase-Catalyzed Synthesis of Complex Glycopeptides and Gly ... -- 3.2. Generation of ENGase-Based Glycosynthases for Transglycosylation -- 3.3. ENGase-Catalyzed Synthesis of Selected Biologically Interesting Glycopeptides and Glycoproteins -- 3.4. ENGase-Catalyzed Transglycosylation for Glycosylation Remodeling of Therapeutic Monoclonal Antibodies -- 4. Endoglycosidases for the Synthesis of Neoglycolipids and Glycosphingolipids -- 4.1. Ceramide Glycanase-Catalyzed Transglycosylation for Glycolipid Synthesis -- 4.2. Endoglycoceramidase-Based Glycosynthase for the Synthesis of Glycosphingolipids -- 5. Concluding Remarks -- Acknowledgment -- References -- Chapter Three: Recent Advances Toward Robust N-Protecting Groups for Glucosamine as Required for Glycosylation Strategies -- 1. Introduction -- 2. The Glycosylation Reaction -- 3. Acyclic N-Protecting Groups -- 3.1. The Acetyl (Ac) Group -- 3.2. The Diacetyl [-N(Ac)2] Group -- 3.3. The Chloroacetyl (ClCH2CO) Group -- 3.4. The Dichloroacetyl Group -- 3.5. The Trichloroacetyl (TCA) and Trifluoroacetyl (TFA) Groups -- 3.6. The Pent-4-enoyl Group -- 3.7. The Trichloroethoxycarbonyl (Teoc) Group -- 3.8. The 2,2,2-Trichloro-1,1-dimethylethyloxycarbonyl (TCBOC) Group -- 3.9. The Allyloxycarbonyl (AOC) Group -- 3.10. The Benzyloxycarbonyl (Cbz or Z) Group -- 3.11. The p-Nitrobenzyloxycarbonyl (PNZ) Group -- 3.12. The Methoxycarbonyl Group -- 3.13. The Ethoxycarbonyl, Chloroethyloxycarbonyl, and Phenyloxycarbonyl Groups -- 3.14. The (1,3-Dimethyl-2,4,6-(1H,3H,5H)-trioxopyrimidin-5-ylidene)methyl (DTPM) Group -- 3.15. The 4,4-Dimethyl-2,6-dioxocyclohexylidenemethyl (Dde) Group.
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3.16. The N-2,4-Dinitrophenyl (DNP) Group -- 3.17. The Diphenylphosphoryl (DPPO) and Dimethylphosphoryl (DMPO) Groups -- 3.18. The N-Alkylacetamido Groups -- 3.19. Fluorous-Protecting Groups (Froc) -- 4. Cyclic N-Protecting Groups -- 4.1. Oxazolines -- 4.1.1. Methyloxazoline -- 4.1.2. Phenyloxazoline -- 4.1.3. 2-Alkoxy Glyco-[2,1-d]-2-oxazolines -- 4.2. Nonparticipating Groups -- 4.2.1. The 2,3-Oxazolidinone Group -- 4.2.2. The 2,5-Dimethylpyrrole Group (DMP) -- 4.3. Participating Groups -- 4.3.1. Five-Membered Ring Groups -- 4.3.1.1. The Phthalimido Family -- 4.3.1.2. The Dithiasuccinyl Group (Dts) -- 4.3.1.3. The Dimethylmaleoyl (DMM) Group -- 4.3.1.3.1. Formation of β Glycosides -- 4.3.1.3.2. Transformation of N-DMM to NHAc -- 4.3.1.3.3. β-(1→4)-Mannosyl-Linked Chitobiose-Type Compounds -- 4.3.1.3.4. Glycolipid Synthesis -- 4.3.1.3.5. Glycosaminoglycan (GAG) Syntheses -- 4.3.1.3.6. N-DMM-Protected Glycosyl Iodides -- 4.3.1.3.7. N-DMM-Based Synthesis of Trehalosamines -- 4.3.1.3.8. Synthesis of Chitooligomers -- 4.3.1.3.9. Synthesis of Murin-Type Oligosaccharides -- 4.3.1.3.10. N-Glycan Syntheses -- 4.3.1.3.11. Human Milk Oligosaccharides (HMOs) -- 4.3.1.3.12. Galactofuranosyl-β-(1→4)-GlcNAc -- 4.3.1.3.13. Glycosylation of 3- and 4-OH-Free DMM-Protected d-Glucosamines and d-Allosamines -- 4.3.1.3.14. Solid-Phase Synthesis of N-Glycans and HMOs -- 4.3.1.4. The Diphenylmaleoyl (DPM) Group -- 4.3.2. Six-Membered Ring Groups -- 4.3.2.1. The Thiodiglycolyl (TDG) Group -- 4.3.2.2. The Dimethylglutaroyl (DMG) Group -- 4.3.2.3. The Diglycolyl (DG) Group -- 5. Latent Amino-Protecting Groups -- 5.1. The Azido Glycosylation Method -- 5.2. 2-Nitro Sugars -- 5.2.1. 2-Nitro Glycals -- 5.2.1.1. O-Glycosides via Michael-Type Addition -- 5.2.1.2. Synthesis of N-Nucleosides -- 5.2.1.3. Synthesis of Glycosyl Phosphonates.
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5.2.1.4. Synthesis of β-C-Glycosyl Compounds (``β-C-Glycosides´´) -- 5.2.2. 2-Nitro-1-thioglycosyl Donors -- 6. Conclusions -- Acknowledgments -- References -- Chapter Four: Carbohydrate-Processing Enzymes of the Lysosome: Diseases Caused by Misfolded Mutants and Sugar Mimetics as ... -- 1. Introduction -- 2. Carbohydrate-Processing Enzymes of the Glycosphingolipid Degradation Pathway -- 2.1. Lysosomal β-d-Galactosidase -- 2.2. Lysosomal N-Acetyl-β-d-hexosaminidase -- 2.3. Lysosomal α-d-Galactosidase -- 2.4. Arylsulfatase A -- 2.5. Lysosomal β-d-Galactocerebrosidase -- 3. Lysosomal Glycogen Degradation and Glycogen Storage Disease -- 3.1. Lysosomal α-d-Glucosidase -- 4. Enzymes of the Glycoprotein Degradation Pathway and Glycoproteinoses -- 4.1. Lysosomal α-l-Fucosidase -- 4.2. Neuraminidase 1 -- 4.3. N-Acetyl-α-d-galactosaminidase -- 4.4. Lysosomal α-d-Mannosidase -- 4.5. Lysosomal β-d-Mannosidase -- 4.6. Aspartyl-N-acetyl-d-glucosaminidase -- 5. Enzymes Involved in Mucopolysaccharide Degradation and Mucopolysaccharidoses -- 5.1. Lysosomal α-l-Iduronidase -- 5.2. Lysosomal Heparan-N-sulfatase -- 5.3. Lysosomal N-Acetyl-α-d-glucosaminidase -- 5.4. Heparin Acetyl-CoA:α-d-glucosaminide-N-acetyltransferase -- 5.5. Lysosomal N-Acetyl-d-glucosamine-6-sulfatase -- 5.6. Lysosomal N-Acetyl-d-galactosamine-6-sulfatase -- 5.7. N-Acetyl-d-galactosamine-4-sulfatase (Arylsulfatase B) -- 5.8. Lysosomal β-Glucuronidase -- 5.9. Lysosomal Hyaluronidase -- 6. Conclusions and Outlook -- References -- Author Index -- Subject Index -- Back Cover.
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