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  • 1
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Proteins: Structure, Function, and Genetics 3 (1988), S. 18-31 
    ISSN: 0887-3585
    Keywords: flexibility ; trp repressor ; DNA-binding domains ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: An orthorhombic crystal form of trp repressor (aporepressor plus L-tryptophan ligand) was solved by molecular replacement, refined to 1.65 Å resolution, and compared to the structure of the repressor in trigonal crystals. Even though these two crystal forms of repressor were grown under identical conditions, the refined structures have distinctly different conformations of the DNA-binding domains. Unlike the repressor/aporepressor structural transition, the conformational shift is not caused by the binding or loss of the L-tryptophan ligand. We conclude that while L-tryptophan binding is essential for forming a specific complex with trp operator DNA, the corepressor ligand does not lock the repressor into a single conformation that is complementary to the operator. This flexibility may be required by the various binding modes proposed for trp repressor in its search for and adherence to its three different operator sites.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Journal of Chemical Technology AND Biotechnology 67 (1996), S. 124-130 
    ISSN: 0268-2575
    Keywords: oxadiazole ; organic fluorides ; synthesis ; insecticidal activity ; structure-activity relationship ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: A series of novel symmetrical and asymmetrical 2,5-disubstituted-1,3,4-oxadiazoles and their intermediates were synthesized. A convenient procedure for preparation of aromatic nitrile and ester intermediates is reported. The insecticidal activities of oxadiazoles against Dropsophila melanogaster were recorded, and analysis of structure-activity relationships showed that the highest occupied molecular orbital energy (EH) was the main factor to affect the bioactivities.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Electrophoresis 16 (1995), S. 1519-1523 
    ISSN: 0173-0835
    Keywords: Capillary electrophoresis ; Drug ; Interaction free energy ; Liposome ; Peptide ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Liposomes, which mimic biomembranes, were used as a pseudostationary phase in capillary zone electrophoresis. The decrease in the mobility of an analyte owing to the presence of liposomes reflected interaction between the analyte and the liposomes. Equations were derived to calculate the specific capacity factor Ks (the capacity factor, K′, normalized to the liposome concentration 1 M) from the migration times and to estimate the difference in free energy, Δ(ΔG0), of the weak analyte/liposome interactions. The order of Ks values for the drugs tested was aspirin 〈 salicylic acid 〈 warfarin 〈 sulfasalazine. The peptide TyrGlySerThrProGlyCysCys interacted more strongly with the liposomes (Ks = 10.1 M-1) than did TyrGlySerThrProGlySerSer (Ks = 9.1 M-1). These results were similar to those obtained earlier by immobilized liposome chromatography.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Publication Date: 2022-05-25
    Description: Author Posting. © American Meteorological Society, 2010. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Climate 23 (2010): 3146–3154, doi:10.1175/2010JCLI3310.1.
    Description: The Atlantic meridional overturning circulation (AMOC) simulated in various ocean-only and coupled atmosphere–ocean numerical models often varies in time because of either forced or internal variability. The path of the Gulf Stream (GS) is one diagnostic variable that seems to be sensitive to the amplitude of the AMOC, yet previous modeling studies show a diametrically opposed relationship between the two variables. In this note this issue is revisited, bringing together ocean observations and comparisons with the GFDL Climate Model version 2.1 (CM2.1), both of which suggest a more southerly (northerly) GS path when the AMOC is relatively strong (weak). Also shown are some examples of possible diagnostics to compare various models and observations on the relationship between shifts in GS path and changes in AMOC strength in future studies.
    Description: We wish to acknowledge support (TJ) from WHOI’s Paul Fye Chair and NASA (NNXZX09AF35G) and to NOAA/OAR (RZ) for this work.
    Keywords: Sea surface temperature ; Meridional overturning circulation ; Gyres ; Coupled models ; Atmosphere-ocean interaction
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
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  • 5
    Publication Date: 2022-05-26
    Description: Author Posting. © American Meteorological Society, 2019. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Climate 32(13), (2019): 3883-3898, doi:10.1175/JCLI-D-18-0735.1.
    Description: While it has generally been understood that the production of Labrador Sea Water (LSW) impacts the Atlantic meridional overturning circulation (MOC), this relationship has not been explored extensively or validated against observations. To explore this relationship, a suite of global ocean–sea ice models forced by the same interannually varying atmospheric dataset, varying in resolution from non-eddy-permitting to eddy-permitting (1°–1/4°), is analyzed to investigate the local and downstream relationships between LSW formation and the MOC on interannual to decadal time scales. While all models display a strong relationship between changes in the LSW volume and the MOC in the Labrador Sea, this relationship degrades considerably downstream of the Labrador Sea. In particular, there is no consistent pattern among the models in the North Atlantic subtropical basin over interannual to decadal time scales. Furthermore, the strong response of the MOC in the Labrador Sea to LSW volume changes in that basin may be biased by the overproduction of LSW in many models compared to observations. This analysis shows that changes in LSW volume in the Labrador Sea cannot be clearly and consistently linked to a coherent MOC response across latitudes over interannual to decadal time scales in ocean hindcast simulations of the last half century. Similarly, no coherent relationships are identified between the MOC and the Labrador Sea mixed layer depth or the density of newly formed LSW across latitudes or across models over interannual to decadal time scales.
    Description: FL and MSL are thankful for the financial support from the National Science Foundation (NSF) Physical Oceanography Program (NSF-OCE-12-59102, NSF-OCE-12-59103). The NCAR contribution was supported by the National Oceanic and Atmospheric Administration (NOAA) Climate Program Office (CPO) under Climate Variability and Predictability Program (CVP) Grant NA13OAR4310138 and by the NSF Collaborative Research EaSM2 Grant OCE-1243015. NCAR is sponsored by the NSF. NPH is supported by NERC programs U.K. OSNAP (NE/K010875) and ACSIS (National Capability, NE/N018044/1). Y-OK is supported by NOAA CPO CVP (NA17OAR4310111) and NSF EaSM2 grant (OCE-1242989). AR is supported by NASA-ROSES Modeling, Analysis and Prediction 2016 NNX16AC93G-MAP. RZ is supported by NOAA/OAR. Argo data were collected and made freely available by the International Argo Program and the national programs that contribute to it (http://www.argo.ucsd.edu, http://argo.jcommops.org). The Argo Program is part of the Global Ocean Observing System (http://doi.org/10.17882/42182). Data from the RAPID-MOCHA-WBTS array funded by NERC, NSF and NOAA are freely available from www.rapid.ac.uk/rapidmoc. We thank Stephen Griffies for providing access to the GFDL-MOM025 COREII simulation output and Matthew Harrison and Xiaoqin Yan for their comments on the manuscript. We also thank the anonymous reviewers for their valuable comments.
    Description: 2020-06-11
    Keywords: North Atlantic Ocean ; Deep convection ; Meridional overturning circulation ; Model comparison
    Repository Name: Woods Hole Open Access Server
    Type: Article
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