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  • Biochemistry and Biotechnology  (1)
  • CFTR Cl− channel  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Cl− channel inhibition by glibenclamide is not specific for the CFTR-type Cl− channel (1995)
    Springer
    Pflügers Archiv 429 (1995), S. 659-662 
    Details
    ISSN: 1432-2013
    Keywords: Epithelial Cl− channels ; Outwardly rectifying Cl− channel ; CFTR Cl− channel ; Glibenclamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract As long as the question of which channels are responsible for cAMP-mediated epithelial Cl− secretion remains unsolved, it is still important to search for specific inhibitors that might help to relate macroscopic to microscopic events. Following the report by Sheppard and Welsh (J Gen Physiol 100: 573, 1992) that glibenclamide inhibits whole-cell Cl− currents in genetically manipulated fibroblasts expressing the cystic fibrosis transmembrane conductance regulator (CFTR), we have studied the effect of glibenclamide on different types of Cl− channels of HT29 and T84 cells at the single-channel level. Our results confirm that micromolar concentrations of glibenclamide inhibit the linear, low-conductance Cl-channel, which appears to represent CFTR and show that the inhibition results from a typical flicker block. However, the same concentrations of glibenclamide inhibit also the outwardly rectifying intermediate conductance Cl− channel which, potentially, may contribute to transepithelial Cl− secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00373986
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Mean light intensity - a useful concept in correlating growth rates of dense cultures of microalgae (1962)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 4 (1962), S. 377-390 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: An analysis of the distribution of light within some culture vessels developed at General Dynamics/Electric Boat is presented. The concept of a mean effective light intensity, Ē, is introduced and procedures are developed for computing Ē for any culture vessel geometry and incident light intensity distribution. A correlation is performed indicating the significance of Ēin assessing the growth rate of dense, continuous cultures of microalagae.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260040404
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    Paper (German National Licenses)
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